6EMQ


Conserved Protein Domain Family
LEDGF

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pfam11467: LEDGF (This model is not part of the current CDD release)
Lens epithelium-derived growth factor (LEDGF)
LEDGF is a chromatin-associated protein that protects cells from stress-induced apoptosis. It is the binding partner of HIV-1 integrase in human cells. The integrase binding domain (IBD) of LEDGF is a compact right-handed bundle composed of five alpha-helices. The residues essential for the interaction with the integrase are present in the inter-helical loop regions of the bundle structure.
Statistics
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PSSM-Id: 519718
Aligned: 24 rows
Threshold Bit Score: 93.5609
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EMQ_A               11 DSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFK--------------------- 69   human
2_pfamImport          1 EVDLLDYIHKLRMALRTDHADYEVALELLEHIIELQVNALMLKKHQEIVETIKALTRYTgnakewnln------------ 68  
XP_002424766        355 ETRLVDIDVLIKTSLQKAKVDVDKALSLMDELINMPLDPLMLKKHPQVVDTTKKLRQYVgnlaewkls------------ 422 
XP_011149472        369 EAQLLQLDAQIKSSLGLDRANADKCLQAMDDILALSIDPLMLKKHPHIVETVKRLRRYIgnladwkln------------ 436 
1_pfamImport          1 ESRLVELDYRIKESISVNRPNCVAAITALDELYSLQMAPLMLKKHPFIVTTILKLKRYIgpkessehteeqkvefysvvf 80  
ETN58932            268 ERELVELNLEIKSTVKLASADAERCVRLLDQYQKLKITPTMLKKNPNCVETIKRLRKYVgnakawnmd------------ 335 
ETN58933            252 ERELVECVLEIKSTVKLAGANAVRCVELLVQFQDLKITPTMLKKNPNCIEVIKELRFYVgnveawnmd------------ 319 
WGS:AAQB:GK15060-PA 833 ERDFIQTVQQLRDCLGFRGANVGKCLKILTDLKNIHISKLLLLRNPECVSVIRRVQKYQgnlkewnms------------ 900 
XP_001990141        343 ERDFIQLSQQLRECLGLRRANVGRCLEILQQLKDVELNKLMLLRNPECVDIMRRLRRYVgnldlwkmd------------ 410 
Q9VAA9              320 ERDFIQLSQQLRECLGLRRANVGKCLEILEQFKEVEFTKLMLLRNPECVDIMRRLRRYVgnlelwkmd------------ 387  fruit fly
6EMQ_A               70 ------------------VSQVIMEKSTMLYNKFKNMFL---VGEGDsVITQVLNK 104  human
2_pfamImport         69 ---------eeetilhneKSTLIRRKAEVIFNKFISLFT---VSDGQ-SFEEIFHK 111 
XP_002424766        423 ---------teekadfeaKAHKIRQKANILFNKYTALFA---VPENS-NFWNIFLD 465 
XP_011149472        437 ---------aeeeaifrqKAEQIRQKAEHIYNKYKAMFT---IPEGQ-SFWQSFSD 479 
1_pfamImport         81 klklcdltlfvtkamykeKSALIRSKASMIYEKFKLLFL---TPEGQ-NFWDNFAE 132 
ETN58932            336 ---------daekskfdiQAQQIRNKADLIYNQFINMFP---THDSEiSFWEAFRD 379 
ETN58933            320 ---------ekqrvnfdyLAKQIRDKAEKIYSQFPSMFP---ELDKDvPFWPAFQE 363 
WGS:AAQB:GK15060-PA 901 ---------hknetdfksKAALIRKLSVEIYNSFIELFTgpkSVEGY-HFWNDFCE 946 
XP_001990141        411 ---------kndeeefkeRATIIREVSTGIYDTFKTLFNt--DTDPEeNFWIEFCE 455 
Q9VAA9              388 ---------lsdevefkeRAQTIRKVSSGIYDGFKSLFNp--EPESEdNFWIDFCE 432  fruit fly
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