Conserved Protein Domain Family
RILP
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pfam11461: RILP (This model is not part of the current CDD release)
Rab interacting lysosomal protein
RILP contains a domain which contains two coiled-coil regions and is found mainly in the cytosol. RILP is recruited onto late endosomal and lysosomal membranes by Rab7 and acts as a downstream effector of Rab7. This recruitment process is important for phagosome maturation and fusion with late endosomes and lysosomes.
Links
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Statistics
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PSSM-Id: 519716
Aligned: 26 rows
Threshold Bit Score: 67.2669
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
ELW65482     415 TLQELRDVLQERNELKARVFLLQEELAYYKSDEMEEEN----RILQPPPVVHPRTAP-----QPESGIKRLA 477
7_pfamImport   1 TLQELREVLQERNQLKAQLLVVQEELQCYKSGIISQTKdqtqEVEKKSHGSSPRTSKd---kEEKKITKRL- 68 
Q0P4J3       125 TLQELRDVLQERNKLKVKLLVAQDELQCYKSGIIPSPDdqivTLENESMITCSPRENe---sKEKSTVKSLF 193 tropical clawed frog
A4IGC3       119 TMQELKEVLQERNKLKAQLLVAQEELQLYKSGVLSSQQnmveVNLETVPQSEPLRSSiteesKEKSTIQKLF 190 zebrafish
XP_003761103 148 TMQELRDVLHERNKLKSQLLVAQEELQCYKSGLIPPNNsqmaRRDPEALITSTTNSKeg--kQEKTIIRKLF 217
XP_056677085 141 TMHELREVLQGRNKLKSHLLVAQEELQCYKSGLVSPSNnqlaRRDPKAPVTDSTTSKra--kQEKTIIGMFF 210
6_pfamImport   1 TLQELRDVLQERNKLKSQLIVVQEELQGYKSGLIAPREgpggRRRNDTVVTRACNANsd--kEEKTIMKKL- 69 
Q6AYA0       123 TLQELRDVLQERNKLKSQLLLVQEELQCYRSGLLPPREtpggRREKDAMVTMGNGEK-----EERTIMKKLF 189 Norway rat
EHB01478     133 TLQELKEVLQERNALKAQLLLAQEELRCYQSGLIPPREgpggRQEKEAAVPRPRSADhr--kGERTIMKKLF 202
A4IFK7       129 TLQELRDVLQERNKLKSQLLVVQEELQCYKSGLIPPREgpggRREKEALFPRGSNANsn--kEEKTIIRKLF 198 domestic cattle
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