Conserved Protein Domain Family
AbiEi_3

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pfam11459: AbiEi_3 
Transcriptional regulator, AbiEi antitoxin, Type IV TA system
AbiEi_3 is the cognate antitoxin of the type IV toxin-antitoxin 'innate immunity' bacterial abortive infection (Abi) system that protects bacteria from the spread of a phage infection. The Abi system is activated upon infection with phage to abort the cell thus preventing the spread of phage through viral replication. There are some 20 or more Abis, and they are predominantly plasmid-encoded lactococcal systems. TA, toxin-antitoxin, systems on plasmids function by killing cells that lose the plasmid upon division. AbiE phage resistance systems function as novel Type IV TAs and are widespread in bacteria and archaea. The cognate antitoxin is pfam13338.
Statistics
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PSSM-Id: 402872
View PSSM: pfam11459
Aligned: 21 rows
Threshold Bit Score: 149.792
Threshold Setting Gi: 93358806
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Sph21_4606   100 KETIHLYGN--DKLPLWTNElseNI-------AFVRHTRNELfsgmerdisgkyTSSVSWKEGFKDLKISCPERACLEML 170 Sphingobact...
jgi:Rmet_6034     94 REKVVLWGQsaYRFPDWVGK---HLtysyqttNLFGESFPYD------------EGLKPLPNGNPSVLVSVPERAFLELV 158 Cupriavidus...
WP_012203092      97 QPVLQLYGWaaGQLPPWFTE---RFpaeyhrkRLFDEQPGDL------------LHVGPFEKRSGAAQVSAPERALLELL 161 Delftia aci...
CAX61042          98 TPHIHLFSAs--PLPAWLHKidiDA-------KFEWRGVQRLwpssvt-enpkyFREDSWRESLPTLCYSGPEKAFLELL 167 Erwinia bil...
chanu:ambt_12825 114 TPHIHLYAQg--KLPSWLGRlslPV-------VCEGHSTNTLwpewlt-kdksfIRLHEWGAELPPVYFSCPEKALLELL 183 Alteromonas...
WP_014993866      95 ASRVHLYSPg--PTPAWLARlpvGV-------DWVWHVTTRLwdqqa--lqdsgSVREQRTPTVEGWPMASPEQAFLEVL 163 Alcanivorax...
WP_010847657      99 SEKVWIGVRnkQSLPKWFKEfpnQ--------NWQYCNNSKLrel-------sdKDFTIVLVNGKELKASTPELAAYEAV 163 Xenorhabdus...
jgi:Q7C_532      113 KEQVWICVKnkSSLPKWFREfpyQ--------NWFYCGNHKLevn-------peKDLKRITVKEKELTVSCAELAAYEVV 177 Methylophag...
WP_015886998     106 SRPAWLYGD---DIPSWLARlqlDApittrtlSLFSEPDLGLtenk-----sasATT---LPWGWAMRISSPERAILEAL 174 Sinorhizobi...
WP_014438567     102 AGGVTLFGPpgVGVPAWLGRlhaAAslevvrsSSLPAGGTDAda----------agVETLAVEGFDLAVSSAERAILEAV 171 Phycisphaer...
jgi:Sph21_4606   171 NDVPRKISFEHADQLIQGMTSLSPRTLQRLLEACTNVKVKRLFLWFASRHNYTWFSKLDTEQIALGSGNRVIA--KEGel 248 Sphingobact...
jgi:Rmet_6034    159 SDVGKNQTLEEVENIIVTMRSLRPPVLHMFLDSCTRLKVLKLVKVLGEESGFDWGKHLQEHVDLRVEAKRLSNklKHS-- 236 Cupriavidus...
WP_012203092     162 SDVGVRQPLQEARELVESAYSLRADVLRELLQRCTSVKTVRLCLQLGREGALPWAARLETASLPKGSDRPWVSrsAEGl- 240 Delftia aci...
CAX61042         168 ADVPKSISVEHADQLMQGLTTLSPRKLDLLLQASSSIKVKRLFLWLANRHQHAWLKYLDPERYELGTGKREIA--KGGrl 245 Erwinia bil...
chanu:ambt_12825 184 VDLPNAVSFEHADEIMQGLVNLSPRKLDTLLKACKSVKVKRLFFWLAKRQNYPWFKKLGETSYDLGSGKRVVA--KSGkl 261 Alteromonas...
WP_014993866     164 ADVPESVSFEHADNLMRGLSALSPRRLNTLLHACRHVRVKRLFFFFADRHPYPWRKRLDPADYDLGSGKRSVV--RGGrl 241 Alcanivorax...
WP_010847657     164 DSIGKHISFEHTAELFQGLVNLSPRKVQSLLNRSKAVQTNRIFLYLSHYHDHQWVKRLDESQIELGSGKRQVV--TQGry 241 Xenorhabdus...
jgi:Q7C_532      178 DGIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIELGAGKRQVV--EKGrf 255 Methylophag...
WP_015886998     175 DELPEHESFHNLDMVFEGLATLSPRRLAALLNSCRKIKVRRLFFVFADRHKHSWRERLQAEEFDLGTGDRALV--KGGkl 252 Sinorhizobi...
WP_014438567     172 LRFPEAVDAETLRHLIEGLVDLRPRRLAELLRACRLQRVVRVFLVLAERARHPWFRHLDLTGLGPGPGKVQVA--GGGvy 249 Phycisphaer...
jgi:Sph21_4606   249 dktykITVP 257 Sphingobacterium sp. 21
jgi:Rmet_6034    237 -----IAQE 240 Cupriavidus metallidurans CH34
WP_012203092     241 -----LVLK 244 Delftia acidovorans
CAX61042         246 dktwqITVP 254 Erwinia billingiae Eb661
chanu:ambt_12825 262 dtdylITVP 270 Alteromonas naphthalenivorans
WP_014993866     242 draylITVP 250 Alcanivorax dieselolei
WP_010847657     242 derykITIP 250 Xenorhabdus nematophila
jgi:Q7C_532      256 deryqITVP 264 Methylophaga frappieri
WP_015886998     253 hpryrITVP 261 Sinorhizobium fredii
WP_014438567     250 vpaqrVSVP 258 Phycisphaera mikurensis
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