Conserved Protein Domain Family

pfam11430: EGL-1 
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Programmed cell death activator EGL-1
Initiation of programmed cell death in C.elegans occurs by the binding of EGL-1 to CED-9 which disrupts a complex involving CED-4/CED-9 and allows CED-4 to activate CED-3, a caspase. It is the C terminal domain of EGL-1 which is involved in the formation of the complex with CED-9. The formation of the complex induces structural rearrangements in CED-9 and EGL-1 adopts an extended alpha-helical conformation.
PSSM-Id: 402854
View PSSM: pfam11430
Aligned: 10 rows
Threshold Bit Score: 32.279
Threshold Setting Gi: 55670073
Created: 21-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
1TY4_D        22 YEIGSKLAAXCDDFDAQXXS 41  Caenorhabditis elegans
CAP25285      70 HDIGTKLAAMCDAFDAEMMS 89  Caenorhabditis briggsae
EGT41478     124 HDIGTKLAAMCDDFDDKIMS 143 Caenorhabditis brenneri
CAS00990      51 HTIGKQLSKLCDDFDKEMMa 70  Caenorhabditis briggsae
Q9TY06        53 YNIGRKLTVMCDEFDSELMS 72  Caenorhabditis elegans
XP_003102005  59 kEIGTKLTTMCDGFDAKMMS 78  Caenorhabditis remanei
1_pfamImport   1 -EIGARIATMCDEFDAELMS 19 
EGT41478     298 YDIGTKVANMCDDFDAKLMS 317 Caenorhabditis brenneri
EGT41478     238 HNIGVKQAVMCDNFDKEMMh 257 Caenorhabditis brenneri
EGT41478     181 HNIGMKLAKMCDDFDDEMMa 200 Caenorhabditis brenneri
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