Conserved Protein Domain Family
Suppressor_APC

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pfam11414: Suppressor_APC (This model is not part of the current CDD release)
Adenomatous polyposis coli tumour suppressor protein
The tumour suppressor protein, APC, has a nuclear export activity as well as many different intracellular functions. The structure consists of three alpha-helices forming two separate antiparallel coiled coils.
Statistics
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PSSM-Id: 519703
Aligned: 20 rows
Threshold Bit Score: 79.2496
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015781886  451 DINTIKRLQQYEQEKEILLQGLEMIERGRDWYIKSINTIQNKIRFIGQTMVnQGDYSLDANQERINFQAARILTVNQHLA 530 
EEC19230      226 EYSMLRRMKQLEQEKNCLQQGLSAVERAREWYQQRIGSVQDKMLQAGKCHT-APEYSMDAQDERLRFQMARILDVNQHLN 304 
XP_002018428  244 DYNMLKRLKQLEEQRELLLFGLDGVEKARDWYMQQVLNVQEQIKYFGRLGT-RFDQWSELQQERLNFQRARVLEANRSLA 322 
XP_032451926  279 DYNMMKRMKQIEQEKDVLLQGLAAVEKARDWYHKQISITQEKIKHLGQMGS-HVEQWTEAQQERLELQRARVLEVNRHLA 357 
1_pfamImport    1 DYNMLKRIKQIEQEKEVLMHGLQAVERARDWYHKQISAVQEKMKYLGRTNS-HTDQWTEAQQERIELQRARVLEVNRHLS 79  
XP_002430363  177 DYNMLKRIKQIEQEKDVLMQGLTAVERAREWYLKQVAIVQEKMKYLGRIGS-HAEQWSEAQAEKLELQKARVLEVNRHLT 255 
3_pfamImport    1 FFLWLQRMQALERRQDALWQGLELLQQGQAWFREHLRAAQGQQLRLGALGE---DFRADSHWEPFGPPLAQIQRVNICLR 77  
XP_046643737  309 DQSMLRRIHILEQERQVLTSGMQALDKARDWFNSQLIDVNERIKSFGKSSIgSSDYSTDAASERLGFKISRIEEVSRQLL 388 
XP_069042274  189 GRVTAQHLEDLCKERTLLLSEIEKEERERRWYYSQLQGLSQRLAELPRVET--FSMQMDLIRQQLEFEAQQLRSVMEERF 266 
Q5SSQ6         35 FFLWLRRMQALEREQDALWQGLELLQHGQAWFEDHLREAQRQQLHLGALGE---NFLTDLHSEPGRPPLAQIQKVNICLQ 111  human
XP_015781886  531 ALM 533 
EEC19230      305 ALI 307 
XP_002018428  323 ILA 325 
XP_032451926  358 ALI 360 
1_pfamImport   80 ALT 82  
XP_002430363  256 TLT 258 
3_pfamImport   78 GLI 80  
XP_046643737  389 VLI 391 
XP_069042274  267 GTS 269 
Q5SSQ6        112 NLI 114  human
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