Conserved Protein Domain Family
HIF-1
?
pfam11413: HIF-1 (This model is not part of the current CDD release)
Hypoxia-inducible factor-1
HIF-1 is a transcriptional complex and controls cellular systemic homeostatic responses to oxygen availability. In the presence of oxygen HIF-1 alpha is targeted for proteasomal degradation by pHVL, a ubiquitination complex.
Links
?
Statistics
?
PSSM-Id: 519702
Aligned: 12 rows
Threshold Bit Score: 41.5155
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_023819367 523 TERDLCDLDLETLAPYIPMDgEDFQLNPIIPEP 555
Q6EHI4       543 STQPMEDLDLEMLAPYIPMD-DDFQLRIPSPLD 574 zebrafish
XP_005986474 547 STQEAEELDLEMLAPYIPMD-DDFQLRSFDQLS 578
5_pfamImport   1 TLENVEEMDLDMLAPYISMD-DDFQLTLLNTLP 32 
4_pfamImport   1 VEQDIEALELEMLAPYISMD-DDFQLNTSDQ-P 31 
6_pfamImport   1 TPFTTQDLDLEMLAPYISMD-DDFQLPCVAVEE 32 
XP_023208360 553 NTEGMEDSELEMFAPYISMD-DDFQLPCLGPDE 584
XP_004753054 516 SQTDFSELDLETLAPYIPMDgEDFQLSPIYPEE 548
XP_009305016 522 SQLNLSDLDLETLAPYIPMDgEDFQLHPICLEE 554
NP_001012371 429 FNCDQCELDLDSLAPYIPMHgEDFLLTPIIDRA 461 zebrafish
NP_001156422 475 IAQDPDTLDLEMLAPYISMD-DDFQLNSSEQLP 506 house mouse
Q98SW2       545 TLQAMEDLDLEMLAPYIPMD-DDFQLRTLSPEE 576 rainbow trout
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap