7LSY


Conserved Protein Domain Family
DNA_ligase_IV
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pfam11411: DNA_ligase_IV (This model is not part of the current CDD release)
DNA ligase IV
DNA ligase IV along with Xrcc4 functions in DNA non-homologous end joining. This process is required to mend double-strand breaks. Upon ligase binding to an Xrcc4 dimer, the helical tails unwind leading to a flat interaction surface.
Links
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Statistics
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PSSM-Id: 519700
Aligned: 14 rows
Threshold Bit Score: 51.9127
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
7LSY_X        750 TKEHFAREYDCYGDSYFIDTDLN-QLKEVFSGIKN 783  human
XP_005997060  753 TEQHFACEYDRYGDSFYADTAEH-QLKEVFLRISK 786 
3_pfamImport    1 TKQHFATEYDCFGDSYYADTDEK-ELKEVFSRISK 34  
XP_008998912  750 TKEHFAREYDCYGDSYFVDTDLN-QLKEVFSGIKN 783 
EDO35746      737 TTAKFREEYDRHGDSFTCDATAD-SLKTVFHNIAN 770 
XP_020433999  864 TRDIFSKEIDPYGDSFTEDTDVQ-TLKDAFKQIER 897 
XP_004362742  816 TKQLLLQDIDRFGDSFTQDTTVD-ELLDSFNQITK 849 
XP_003287084  898 TKKKFLLESDPFGDSYFNETNFS-ELKDCFNQVDK 931 
Q54CR9        924 TKKRFLLDSDQFGDSYINETTEQ-SLKDSFNQIDK 957  Dictyostelium discoideum
XP_002111010  749 TAEVFAKEYDKYGDSYTKDIDNPvALKAIFDKINN 783
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