5UQ2


Conserved Protein Domain Family
Spy1
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pfam11357: Spy1 (This model is not part of the current CDD release)
Cell cycle regulatory protein
Speedy (Spy1) is a cell cycle regulatory protein which activates CDK2, the major kinase that allows progression through G1/S phase and further replication events. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27. Spy1 is also known as Ringo protein A.
Links
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Statistics
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PSSM-Id: 519685
Aligned: 27 rows
Threshold Bit Score: 166.276
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5UQ2_B         16 QDMTAFFKLFDDDLIQDFLWMDCCCKIADK-----------YLLAMTFVYFKRAKFTISEHTRINFFIALYLANTVEEDE 84  human
XP_008208426   27 WNVRRFFKLLDS--LADFLESDKCYRLADN-----------YLIAMVFTYFLRASLEPDEYTQQNFFAALFLAYNMEEDE 93 
XP_004913710   62 QERQAFYRLLENELIQEFLSMDSCLKISDK-----------YLIAMVLAYFKRAGLYTSEYTAMNFFVALYLANDMEEDE 130
XP_056657349   39 QEVRAFLNLLEDSYLQQFFATDLCFQISDK-----------YLLAMALIYFQRAGLQLSEYTHSNLFLALYLANDMEEDR 107
10_pfamImport   1 SQYQAFLSLLEDSFFQEFLSKDPCFQISDKrrrltnslslqYLLAMVLVYFRRANLKLSEYTRSSLFLALYLANDMEEDV 80 
5_pfamImport    1 LELRAFLRLLEHSCLQEFLARDPCFQVSDK-----------YLLAMVLVYFRRANLQLSEYTCSNLFLALYLANDMEEDL 69 
8_pfamImport    1 DEINAFFAIFDDTTIQEFLNLDSCCRVSDK-----------YLLAMVLTYFKRAHLHVCEYNNINFFTALYLANDMEEDE 69 
XP_019849841  171 SSIVAFLRLCEDEVICNFLWVDSCAKISDK-----------YLLAMVYIYFKRASLPLDQYNQFNFFVALYLANDMEEDE 239
9_pfamImport    1 QEMASFFNLFDDQLIRDFLLKDSCCKMTDK-----------YLLAMTFVYFKRARFAVAEYTRKNFFIALYLANTMEEDE 69 
XP_064407782   87 LERQAFYRLLDDDLIQEFLSMDACYRISDK-----------YLLAMVLTYFKRSGLYTTEYTRMNFFVALYLANDMEEDE 155 coelacanth

5UQ2_B         85 EETKYEIFPWALG-KNWrK-LFPNFLKLRDQLWDRIDYRAIVSRRCCEEVM-AIAPTHYIWQRER 146 human
XP_008208426   94 GEFLLAEL------EDWlDcTVADLKQVRYELFQRVEYRGAVSRACCDIVMrSANPEHKVWQRRR 152
XP_004913710  131 EDFKYEIFPWALG-DSWrE-IFPQFLRLRDNFWAKMNYRAVVSRKCCDEVM-SKDPTHWAWLRNR 192
XP_056657349  108 EDPKYEILPWALG-QGWrK-LVPSFLRQRDQLWARMGYRAAVSRHCCEEVM-AKEPSHWAWTRER 169
10_pfamImport  81 EDFKCEIFPWALG-EDWsS-RVRKFLHQRDKLWARMGFRAAVSRQCCEERE-RQDP--------R 134
5_pfamImport   70 EEAKCMIFPWALG-EGWhN-QVADFLRQRDKLWARMGFRALVSRRHCEKVM-AMEPSHWAWTRER 131
8_pfamImport   70 EEFKYEIFPWALG-DTWrD-LYPGFLAKREQLWMKMKHRAAVSRKTCEQVM-GIEPDHYIWSRER 131
XP_019849841  240 EDDKYEIFPWALGkKSWtS-TYPLFLSYRDELWSKMDFRAVVSKRMCDEVI-SLVPDHRIWKRQR 302
9_pfamImport   70 EEIKYEIFPWTLG-KNWkK-KFPVFLKQRDELWARMEYRAAVSRHCCEEVM-AIYPSHSLWQRER 131
XP_064407782  156 EEYKYEIFPWALG-HKWkE-SFPWFLKLRDRLWSRMNYRAVVSRRCCEEIM-AMDAAHWAWLRER 217 coelacanth
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