7LBM


Conserved Protein Domain Family
Med25_VWA

?
pfam11265: Med25_VWA (This model is not part of the current CDD release)
Mediator complex subunit 25 von Willebrand factor type A
The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA domain which is this one, an SD2 domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and a C-terminal NR box-containing domain (646-650) from 646-747. This VWA or von Willebrand factor type A domain when bound to RAR and the histone acetyltransferase CBP is responsible for recruiting Med1 to the rest of the Mediator complex.
Statistics
?
PSSM-Id: 519657
Aligned: 14 rows
Threshold Bit Score: 261.868
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
7LBM_3        12 GSVVADVVFVIEGTANLGPYFEGLRKHYLLPAIEYFNGGPP-AETDFG-GDYGgTQYSLVVFNTVDCAPESYVQCHAPTS 89  human
Q6PEH8         9 LNQVSDVVFVIEGTANLGPYFESLRNNYILPTIEYFNGGPP-AETDFG-GDYGgTQYGLVVFNTVDCAPESYVQCHAPTS 86  zebrafish
EEC17383       7 GNWVADVVIVVEGTANLSPYVDSLKSHYIVPTLEYFNGGPI-DDRDCG-YDTNsTTYALVVFMAADCATEPAATCNAPTT 84 
EFA02633       8 HGLQADIVFVIEGTAVNGAYINDLKTNYIIPSLEYFSQGSI-DESSFL-SEGInSYYGIVVYQAADCLPHPSSDTIGPFV 85 
EFN70189       8 HGIQADVIFVIEGTAVNGAYLNDLKTNYLIPTLEYFSQGGI-EDREYV-SENStTLYGIVVYHAADCLPSPCTETFGPYS 85 
1_pfamImport   1 HSVQTDIIFVIEKTA-MNTYISELKTNYVTPTLEYFNQGPI-EERDYL-SESSsAIYGIVVYEANDCKPYPCCRTYGTFT 77 
XP_002426584   8 HTVQADIVFVIEGTAINGAYLNDLKTNYLLPTLEYFSQGNL-EDRDYV-CEGTsTLYGLVVYHAADILPKSSCDCYGPYS 85 
3_pfamImport   1 ICALADVIFIIEGTAINGAYLNDIKTNYIIPTLEYFNQGNL-EERDYV-CESTsALYGIVVYHAADRLPSPSTDIYGPYS 78 
EDO35921       6 SHGEHEVVFVVEGTANLLLHFETLKTEYIDPIIEYINGGPVqESNSFFgDENGpNQYCLVVYGTKASHPEDAVQLVRYTR 85 
XP_009008966   6 NQKVYDVAIVVEATSGAADYYETMRTSYLLPILEFFNGHSI-DEPVYG-YCCNsSLYSLITYKGNDHPFSNMSTCSSPTY 83 
7LBM_3        90 SAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIG-QTHRVCLLICNSPPYLLPAVESTTYSGCTTEN 168 human
Q6PEH8        87 SAFEFVSWIDSIQFMGGGAESCSLIAEGLSVALQLFDDFKKMREQIG-QTHKVCVLLCNSPPYLLPAVESVSYTGCTADS 165 zebrafish
EEC17383      85 NVAKLLSWFDRVSFVGGGGESCSHIAEGLGTALQVFDDFQALRE-PSvVVQKHCVLVCNSPPYRLPSLESPVYAGHTVDQ 163
EFA02633      86 SPSKVLNAIDKLELIGGKGESHANIAEGLATTLQCFDELQQKRDNNG-NIQKHCILVCNSPPYSLGVFETHAYTGKTAEQ 164
EFN70189      86 NPHKLLVVLDKLEMVGGKGESCANIGEGLATGLQCFEDLQLRREPNT-ASQKHCILICNSPPYQIMIQESYKFAGHTIEQ 164
1_pfamImport  78 SPQKVIKMIEKIDMIGGMAESHAYMGEGLATALVFFEDLQEIRE----AKQRHCILICNSPPYNFPIMECETYAGRGVDQ 153
XP_002426584  86 SPQKLLMTLDKLELIGGKGESHANIAEGLATALQAFEDLQQKREGNNiITQKHCILVCNSPPYFMPVMEASTYSGHTIDQ 165
3_pfamImport  79 NPHKVLQMLDKIELVGGRGESHANVAEGLASSLICLDDLQQRRE-PGlAPQRHCILISNSPPYMMPVVENQAFTGNTAEQ 157
EDO35921      86 DVHDFLQALNEVKFDGGGGQDCSLLAEGMGFALQAFDEMRVSRGSV--NCHRHCIVVCNSPPFPQPSRECLSYLNKTVDQ 163
XP_009008966  84 NCHEFAQTLNQISFSGGMLDPHSFIAEGLATALSLFEDIDLIRKNRV-KAEKHLILYCSNGPYQFPCLGHYKYLNKTTEQ 162
7LBM_3       169 LVQQIG--ER-GIHFSIVSPRKLPALRLLFEKAA--PPallE--PLQPPTDVSQDPRHMVLVRGL 226 human
Q6PEH8       166 LVQIIR--DR-GIHFSVIAPRKLPALRSLFERASsvAG---L--PESSHPDYSQDPFHMVLVRGI 222 zebrafish
EEC17383     164 LAGIMA--ER-QVNFSILSPRKIPALYKLYEKAG--GD---L--QLALAKNYAKDRRHMVLLRGY 218
EFA02633     165 LAAILQ--EK-NINLSIISPRKIPSLYKLFEKAG--GD---L--SASQTKNYAKDPRHLVLLRGF 219
EFN70189     165 LAAIYQ--ER-NINISILSPRKIPALYKLFEKAG--GD---L--QSSQTKNYAKDPRHLVLLRNY 219
1_pfamImport 154 IANLFQ--EK-GILLSILSARKTPALLKLFEKAG--GD---L--QISQNKNYAKDPRHLVLLNGY 208
XP_002426584 166 LAAILN--EQ-NINLSILSPRKIPAIFKLFEKAG--GD---L--TQSQNKNYAKDPRHLVLLKGF 220
3_pfamImport 158 LASLLN--ENiNVHLSILSPRKIPAMFKLFEKAG--GD---L--SASQNKNYAKDPRHLVLLKGF 213
EDO35921     164 LAAIMAkpEN-NIHLSIISPRKFPALQLVFDKSL--RD---DtkGMKSKTDYAKEPQHMACLQGI 222
XP_009008966 163 LVNLLA--ES-NIHFSIISTRKIHSLVKLFELGQ--PD------PSCLTKNYASDSTHLVLLNDI 216
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap