Conserved Protein Domain Family
Tho2

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pfam11262: Tho2 (This model is not part of the current CDD release)
Transcription factor/nuclear export subunit protein 2
THO and TREX form a eukaryotic complex which functions in messenger ribonucleoprotein metabolism and plays a role in preventing the transcription-associated genetic instability. Tho2, along with four other subunits forms THO
Statistics
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PSSM-Id: 519655
Aligned: 114 rows
Threshold Bit Score: 161.247
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5KLR9       1112 EVMSAPFFVIFWHLTTPDIAFSPQSYDNAIKSINRHISTIsswwvnprDKSKMAE------Q--RDELARL---KAR--- 1177 Cryptococcus ...
Q18033        863 ENIPVKFFAVFWMLTMYDIEVPTAAYERTLDALKKQSREds------------------hgKa-KKTDKQL--------- 914  Caenorhabditi...
7_pfamImport    1 DTVPLRFFAVFWMLTMYDIEVPVSAYDRTIESLKKQSSREds-----------------hsKgnKKTDKQL--------- 54  
4_pfamImport    1 --LTSKLILIFWALSLPDVYIPTKKYAQVVTNMNEAKRRAd-------SKLQQAEeeg-vtMs-KAERSRYmldRKTspa 69  
XP_001614024 2037 NGINIDFYLTYWRLSITDIYVPHKQYQKVIERYDAYIKKLe------kHHEENKKned-ykWv-LKKLRKL---RSK--- 2102
Q8I4T6       2413 NGININFYLTYWRLSISDIYVPHKQYQKVLDKYENYIKKLe------kYYEENKKnde-ykWi-PKQIKKL---NIK--- 2478 Plasmodium fa...
Q4N3V4        402 TMLDDNFVGFINSLSIYDIYSPTEQYDTYVSKLTSFLSTIt------tAGAGNT----------FRRAKRI---KNR--- 459  Theileria parva
Q4UFM1       1521 NILDDNFIGFINNLNIYDIYTPVEQYDNYITKLTS--------------GIGNT----------VRRIKRI---KNR--- 1570 Theileria ann...
A0BH94        916 TIINPELFAIFWLLSLDNIYVPQAIYDQQLKWLQENINKNpdt----------------kdRq-SKQHQKA--------- 969  Paramecium te...
XP_002899365  908 tGLTPEVYATFWGLKLYDIHIPFQQYESEILRLRNSVTS-------------GANaslsasEr-KKLKEKT---TQM--- 967 
Q5KLR9       1178 -VKVLQEEKEAHGSLVNGpMKRRMRLESGK-WFGka-iVEKNLQRPLAIQLHQYCFYPRAILSPCDAVFVAKFIRMAHNL 1254 Cryptococcus ...
Q18033        915 -ESKLREEQKRQIEHVER-CKVWLLNKKDS-LID------EQFHNSVLEALIQQCLLPRAIFSELDAVFCGQFFMMLHEM 985  Caenorhabditi...
7_pfamImport   55 -ESKLKEELKRQTEHVER-CKTWLLNRKDS-LID------EKFHNSVLEVLIQQCLLPRAIFSELDAVFCGQFFLMLHEM 125 
4_pfamImport   70 vAAKLETEKGSQSAHVKR-VKNKLREIKAS-LFAa--kDKHETGAETIDAVLKHLVAPRMGMGPEEAYFCSKFFNTLHAI 145 
XP_001614024 2103 -RGTINSEYQFHIQHTEK-IKKHLSHVVDH-WVN-----PQEIDLTTFTAFVKCLIAPRILNSEKDSLFCSKFILLLLEF 2174
Q8I4T6       2479 -KNNLKNEYEYHINHTKQ-IKQYLAHIVDH-WVD-----PQKVSLNTFVAFIKCLIAPRILNSEKDSLFCSKFIQILLEL 2550 Plasmodium fa...
Q4N3V4        460 -ITTLETDKEEHLTHSNV-VLERLKEVFKS-FVK----NDAKVGPHITTRFISRIVFSRLLVSELNALFCCKIVDLIMEN 532  Theileria parva
Q4UFM1       1571 -ITILETDKNEHIQHTNM-ILSHLKEVLKR-FVK----NDNKVGPHITMRFITRIIFPRLFVSELNALFCCKIVDTILEN 1643 Theileria ann...
A0BH94        970 -FDKLQNELDNNKKRQEQ-FDKCLRDKKHVfSFKeadqAKENYHIKFAQCLSQVCLLPRILIDPAEAIYCAKFVQKMLKI 1047 Paramecium te...
XP_002899365  968 -IDVLTTEQKEQVAHRKR-VYERLEKMKSK-FFK----DEPNDHQTAIDELLQKCVIPRSLMSPEDALFAAKFMERLHTF 1040
Q5KLR9       1255 GTVGFSTLFVYNNFFNDNLAACIFSCTDSEARNLGRCLALILADLDKWHQ--SENVYLKEALGispnpieggEQKRLP-- 1330 Cryptococcus ...
Q18033        986 RTPFFPSVLIIDRLFEN-IIPLIAGLTENEANSLACFFEILLCTVQRWHS--EKEVFEKEC-------------AGFP-- 1047 Caenorhabditi...
7_pfamImport  126 RTPFFPTIYIIDRCFEN-TINLIAGLTENEANALACFYEILLVTVQRWHS--DEKIFEKEC-------------AGFP-- 187 
4_pfamImport  146 EAPNFNSLVFYSRSFEG-LSSTLLCKTQYEAAGLGFFLKDLLENVKEWRKtkNEAIYKMEA------------------- 205 
XP_001614024 2175 RTPLFNFCLLTYVCIKM-LMPIINACTEKEALNIGLFFNELFSYAYQLCQ--DPKHFKL--V-----------SEENPcf 2238
Q8I4T6       2551 HTPLFNLCTLVYIFTKM-LMPLINACTEKEALNIGIFFNDFFSYIYLLCE--DIKYFQN--V-----------SNKNPcf 2614 Plasmodium fa...
Q4N3V4        533 KMNYFNYFDFVNCYTKM-LIPMISSLTEREVINLSIFFNHSFHLIKGWVN--NREAFEK--L-----------VYDNPcf 596  Theileria parva
Q4UFM1       1644 KMNYFNYFDFVNCYTKM-LIPMISSLTEREVISLSIFFNHSFQLIKAWVN--DRDAFEK--L-----------VYDNPcf 1707 Theileria ann...
A0BH94       1048 GKPRYTYTFYVPKEIIYFTFTYLQCATEEEASNLSIFMQQLIIPYANWN---DETKFKN--------------------- 1103 Paramecium te...
XP_002899365 1041 STPQMSTLQYIHKVNMK-VSAIVLCATEREASNFGIFMKETLGLILRWYQ--NGATYDDEAIHg--------KM------ 1103
Q5KLR9       1331 ----GMLFRSkAGdd--------mREMSWQEFRNFYAKCHNVLTRALIS------------------------------- 1367 Cryptococcus ...
Q18033       1048 ----GMITK---------------QAIEYQTFRKLCYRWQIRFTAMFKT------------------------------- 1077 Caenorhabditi...
7_pfamImport  188 ----GMITK---------------SAIEYQTFRKLCYRWQNRFQTMFKL------------------------------- 217 
4_pfamImport  206 ----GTKHGFnLGdasqsvvegkaPQVNHAAFVKISGEWSMQVTKAVMA------------------------------- 250 
XP_001614024 2239 sstlNFQSK---------------VTIEHSFIIGKVAKWEKLLVSLLFE------------------------------- 2272
Q8I4T6       2615 sytlNFQSK---------------DTITHNNIIQKVMKWEKTILSLLFE------------------------------- 2648 Plasmodium fa...
Q4N3V4        597 cttfKFQPN---------------REFKYQQLLQVIKKWEYFILLSIFSinkpptstnsansansansttsassv----- 656  Theileria parva
Q4UFM1       1708 cttfKFQPN---------------KEFKYQQLLQVIKKWEYFILLSIFSsvtgsgqtatninkvnstnnsnsikdssstv 1772 Theileria ann...
A0BH94       1104 ----DLRNYFdT------------SIDGYDREKQYII---QNIFFKMAQ------------------------------- 1133 Paramecium te...
XP_002899365 1104 ----GLSLDLhDDk----------KRLAHRQFKSAYARWHKQLELVYTT------------------------------- 1138
Q5KLR9            --------------------------------------------------------------------------------      Cryptococcus ...
Q18033            --------------------------------------------------------------------------------      Caenorhabditi...
7_pfamImport      --------------------------------------------------------------------------------     
4_pfamImport      --------------------------------------------------------------------------------     
XP_001614024      --------------------------------------------------------------------------------     
Q8I4T6            --------------------------------------------------------------------------------      Plasmodium fa...
Q4N3V4        657 -----------------------------------------------------------------kddkgrvgdlknsae 671  Theileria parva
Q4UFM1       1773 vtsnkdstsnkvnsstvvtstsntkstttsnkdsntkdskankdtnsikgapfgagnkdskstsstmgstmgtttgtaga 1852 Theileria ann...
A0BH94            --------------------------------------------------------------------------------      Paramecium te...
XP_002899365      --------------------------------------------------------------------------------     
Q5KLR9       1368 ----------CW--SEAEFMHNKNAIIVALQVIKYFPLMETNGKAIEAA---VKKLQAGEVge------------iPNDL 1420 Cryptococcus ...
Q18033       1078 ----------VFtkDDADYVLIRNSLIMMTKLTSGFPVISHAVATMETA---VTKLKDREKg-------------kRDDL 1131 Caenorhabditi...
7_pfamImport  218 ----------VLtkEDTNYTLIRNSLIMMTKLTSGFPVLSHAVETMEQI---ATKLKEREKg-------------kRDDL 271 
4_pfamImport  251 ----------AV--ASDEFLLIKCGLIMYNKLIETFPV----------------SLKERKLlrlklqpktdkaiepRDDI 302 
XP_001614024 2273 -----------NnnHQKSWINSKSVVIFLFRVLHSFPYSNKVKHSIRKYlqnLHSFAQSRG---------------WKDI 2326
Q8I4T6       2649 -----------NnnFEKSWINSKSVVIFLFRFLNTFPYSHKIKNSIKTYlenLQNFANNQG---------------WKDI 2702 Plasmodium fa...
Q4N3V4        672 semasepesvLP--QKRSWIEIKNVVIFLNKVSSNFPITVNSSLKVLNFlknVLKLAKQNN---------------WQDV 734  Theileria parva
Q4UFM1       1853 stvtgtvtdeSP--IVQSWIEIKNVIIFLNKVSNNFPITINSSLKVLNFlknVLKLAKQNN---------------WQDV 1915 Theileria ann...
A0BH94       1134 ----------FIriLKNNETQVRNALIFLKRVQDIFPPTQQVAEYIKIY---LQDVEKDYGh--------------IQDI 1186 Paramecium te...
XP_002899365 1139 ----------AL--SSGEYMPIRNSLVVLTKLIDVFPAGRGTADVILVI---VEKLTSED----------------REDI 1187
Q5KLR9       1421 KMMCTSFLSGL 1431 Cryptococcus neoformans
Q18033       1132 SLKAASYVGKL 1142 Caenorhabditis elegans
7_pfamImport  272 SLKAASYVGRL 282 
4_pfamImport  303 RVPCTRIVNQL 313 
XP_001614024 2327 AISVNSL-KTI 2336
Q8I4T6       2703 VISINSL-KTM 2712 Plasmodium falciparum 3D7
Q4N3V4        735 TVPSNTLIKLI 745  Theileria parva
Q4UFM1       1916 TVSSNTLIKLI 1926 Theileria annulata
A0BH94       1187 KTQIKNFhied 1197 Paramecium tetraurelia
XP_002899365 1188 KIMAKRYFALL 1198
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