Conserved Protein Domain Family
FAF
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pfam11250: FAF (This model is not part of the current CDD release)
Fantastic Four meristem regulator
FAF is a family of plant proteins that regulate the size of the shoot meristem by modulating the CLV3-WUS feedback loop. The proteins are expressed in the centre of the shoot meristem, overlapping with the site of WUS - the homeodomain transcription factor WUSCHEL- expression. FAF proteins are capable of modulating shoot growth by repressing WUS in the organising centre of the shoot meristem. The ability of plants to form new organs throughout their life cycle requires tight control of the meristems to avoid unregulated growth. Plants have evolved an elaborate genetic network that controls meristem size and maintenance. WUS and the CLAVATA (CLV) ligand-receptor system are at the core of the network that regulates the size of the stem cell population in the shoot meristem.
Links
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Statistics
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PSSM-Id: 519648
Aligned: 65 rows
Threshold Bit Score: 39.0544
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
EFJ26702       34 EFPPPMPSLArtSyNhlplqvPWTLLSANRSNNRVVLHEIKAAHGAQLmlFQPIRSQGRLVLQM 97 
XP_025012533  126 lYPPPITCLklfk-----tgkPYTYLTFKEDDGSFVFENIKIPNRDI---LHASRAEGRLKLYF 181
PNT18399      120 lFPPPISCLrlfn-----kgmPCRYLNYNEENDSFELEEIKIPQGDI---LRANRSGGRLRLTL 175
XP_020523735  150 NFPPPLSTL---SkNg----qVSYFLKPVKTEGRFILREVVIL-RQEV--LRACRENGRLRLHM 203
9_pfamImport    1 SFPPPLSSL---NrNg----kPSFYLRPVRKDGRLELTEVRIQ-RSEI--LHASRHNGRLTLRL 54 
XP_003535351  133 NFPPPLSSL---NgNg----qPSFILVPVRKNGRLQLTKVRIK-RPKI--LYATRQDGRLRLLL 186
EFH70860       89 KFPPPLSSF---NgRg----kRSFYLRPVRKDGRLELTQVMIN-RPEI--FHASREDGRLRLHF 142
12_pfamImport   1 EFPPPLSSL---SqDg----kPNFFMRAVRKDGRLELTEVKID-RPKT--FRASRQDGRLRLHL 54 
XP_019071453   55 SFPPPLSSL---NqDg----kPIFSLKPTRKDGKLELNEVKMDIPSSI--VVTSRQQGRLRLNL 109
NP_001118896  111 DLPPFLTTLDcnGr-------PRFHHRRVRSEGRLEIASVAVDSPE----IVSVR--GREGLRI 161
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