Conserved Protein Domain Family
Med25_NR-box

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pfam11244: Med25_NR-box 
Mediator complex subunit 25 C-terminal NR box-containing
The overall function of the full-length Med25 is efficiently to coordinate the transcriptional activation of RAR/RXR (retinoic acid receptor/retinoic X receptor) in higher eukaryotic cells. Human Med25 consists of several domains with different binding properties, the N-terminal, VWA, domain, an SD1 - synapsin 1 - domain from residues 229-381, a PTOV(B) or ACID domain from 395-545, an SD2 domain from residues 564-645 and this C-terminal NR box-containing domain (646-650) from C69-747. The NR box of MED25 is critical for its recruitment to the promoter, probably through an interaction with pre bound RAR.
Statistics
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PSSM-Id: 402709
View PSSM: pfam11244
Aligned: 4 rows
Threshold Bit Score: 80.4399
Threshold Setting Gi: 182627713
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ELK18520     600 AGVPPPQAPLHHLQPpGAPPMLPPP-------HQGLGQPQL---GPPLLHPPPTQSWSAQLPPRAPLPGQMLLSGAPRGA 669 black flying fox
A4IHD9       703 TSVPQTQQPLHHMQQ-AAQGMLPHQamgqqmqHQAPGQQQLqlpGQTLMHQAPAQQWGNQMQQRAPIPGTLMMSAGPRGP 781 tropical clawed...
ACB88876      32 slllnppppqtgvpppqaslhhlqppgapallppphqglgqpqlgppllhpppAQSWPAQLPPRAPLPGQMLLSGGPRGP 111 human
XP_007507968 569 ARGPPPQASLHHLQPpGAPSLLPPS-------HQGLGQPPL---GPPLLHPPPAQSWPGQLPPRAPLPGQMLLSGGPRGP 638 gray short-tail...
ELK18520     670 VPQPGL----PPSVMEDDILMDLI 689 black flying fox
A4IHD9       782 VPQQGLqqvqAQSVMEDDILMDLI 805 tropical clawed frog
ACB88876     112 VPQPGL----QPSVMEDDILMDLI 131 human
XP_007507968 639 VPQPGLq---PPSVMEEDILMDLI 659 gray short-tailed opossum
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