Conserved Protein Domain Family
Focadhesin

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pfam11229: Focadhesin (This model is not part of the current CDD release)
Focadhesin
Focadhesin (FOCAD) is focal adhesion protein with potential tumour suppressor function in gliomas. The structure prediction indicates that it consists in repetitive alpha hairpins that adopt an armadillo-like fold.
Statistics
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PSSM-Id: 519640
Aligned: 12 rows
Threshold Bit Score: 1018.51
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_028908675 1177 MNKIRMLTEKNQQTPGFALALGNLVHGLSVCGHGKAEDLSNKLLPPWIKIVLTEGSSTMQCLAALNGLVSLVGSEGVLFQ 1256
8_pfamImport    1 MNNLRLMTEKSQQTPGFALSLGITVHGLSACGHGKAEDFYFRLLGAWIKILLTEGCPTMQRLAAVNGLVALVGSESSLIQ 80  
XP_007498129 1216 MNKLRTLVENNQQNSGFALALGNIVHGLSVCGHGKAEDLSNRLLPAWIKIVLTEGSPTMQCLAAVNGLVALVGSEGAIMQ 1295
1_pfamImport    1 MNKLQKLTESNQQTAGFALALGNIVHGLSVCGHGKAEDLGNRLFPAWMRILLAEGAPTMQRLAAINGLVSVVGSEGTMIQ 80  
XP_038026105 1215 MNKLRTLVEDNQQTSAFALALGTIVHGLSVCGHGKAEDLRNKLMPAWIKTLIAEGSPTMQRLAAVNGLVALVGSEGGMIQ 1294
7_pfamImport    1 MNVLRSVTEESQQTPGFALALGLTVHGLSSCGHGKAEDIHPRLLAAWTKILLAEGCPTMQRLAALNGLIALVGSETGLLQ 80  
3_pfamImport    1 MNTLRALTEESQQTPGFSLALGLVVHGLSMSGHGKAEDIHHRLLAAWIKILLAEGCPTMQRLAAANGLVALVGSESSLIQ 80  
XP_019204834 1217 MDTLRSLTEESQQTPGFSLALGLAVHGLSVSGHGRAEHIHPHLLAAWIKILLAEGCPTMQRLAAVNGLVALVGSESYLIQ 1296
6_pfamImport    1 MKALRCLTEDNRQAAGFSMALGMLVHGLAACGHGKAEEAQPHLLASWMKTLLTEGCPTMHRLAALSGLLALVGSEANVFQ 80  
XP_011604804 1212 MNTLRNLTEESQQTTGFSLALGMVVHGLSMCGHGKAEDIHPHLLASWMKILLAEGCPTMHRLAAVSGLVALVGSESCIIH 1291 torafugu
E7FGT5       1221 MNTLRALTEESQQTPGFALALGQTVFGLSSFGHGKAVDIQPRLLAAWTKILLAEGCPTMQRLSALNGLIALVGSETALIQ 1300 zebrafish
XP_064410830 1216 INKLRALTEQNQQTPGFALALGVIVNGLAVCGHGKAEDLSNRLLPAWIKILLAEGCSTMQRLAAVNGLVTLLGSETSLIQ 1295 coelacanth
XP_028908675 1257 MKSDPIQSSQFQGKLKEVIRTIIQLTNLSAVIGVQSNAVWLLGHLHLSSLSANQSRASVPADFSYLSENSFIRAAIDFLI 1336
8_pfamImport   81 LKSESGQSPQQQSRLNEVIRAITQVITFSGAVGLQSNASCLVGHLHLANLSLGQTRTSVPPDFGYLSERSVIRAAVDYLI 160 
XP_007498129 1296 LKSETIQASHFQSQLNEVIRTITQVISFSGVIGLQTNAAWLLGHLHLSSLSSSQSRTSVPADFSYLPENSFIRAAVDFII 1375
1_pfamImport   81 LKTEAIQSSQFQSKLNEIIRTLSQIISFSGVIGLQTNAAWLLGHLYLSTVSATCSRTSVPPDFSYLPEKSFLRAAIDFVI 160 
XP_038026105 1295 LKSESIQSSQFQSMLNEVIRTLTQIISFSGQIGLQTNAAGLLGHLHMSCLSSTQSRASVPPDFSYLPENSFIRAAIDFAI 1374
7_pfamImport   81 LKSETEQSSQQQARLNEVIRSITQIISFSGAIGLQSNGACLVGHLHLAHMSSSHSRTAVPQDFSYLPERSLIRASVEYIT 160 
3_pfamImport   81 QTSELELSSQKRSRLNEVIRAITQIITSSGAIGLQSNSACLVGHLHLAHVSTSHSHTAVPQDFSYLPEKSLIRSIVDFIS 160 
XP_019204834 1297 LKSETELVSKQQNRLNEVIRAVTQIITFSGAIGLQSNSACLLGHLHLAHMSSSHSHTAVPPDFSYLSEKSVVRSTTEFIT 1376
6_pfamImport   81 LEAELEASSQQQSRLNEVIRAVTQVITLSGAIGLQSNCACLLGHLHLSQVSNSPRPGAAPQDFSYLPERSVLRWVVSFLT 160 
XP_011604804 1292 LKSELEISSQQQSRLNEVIRAVTQVVTLSGAIGLQSNSACLLGHLYLAHMSNSCSHSSVPQDFSYLPEKSVIRSVATFLT 1371 torafugu
E7FGT5       1301 MKSECEETSLQHSRLNEVIRAITQIITFSGTIGLQSNGACLLGHLHLTHASSRHSRTAVPQDFGYLSESSVIRASVDFIT 1380 zebrafish
XP_064410830 1296 LKSETIQSSQFQSKLNEVIRTITQIISFSGVIGLQSNAAWLLGHLHLANLSASQSRTSVPPDFSYLSEKSVIRAATDYIV 1375 coelacanth
XP_028908675 1337 DGGKK--G---PESVPASCVKTVMKPIVTVGKSYQYPPVNWASLLSPLLRLNFGEEVQLLCIQLMVtqAQSSQNAAMLLG 1411
8_pfamImport  161 EAGRK--G---PEHLHPKLVNVVLGPLASVGSSFQYPPVNWGAILSPLMRLNFGNTFAKICQEIAI--ADNLRSSSFLAG 233 
XP_007498129 1376 EGGKK--G---PESVPPSLVKVAMKPIATVGENYQYPPVNWASLLSPLMRLNFGEEVQQLSIEIMVtqAQSSQNAAMLLG 1450
1_pfamImport  161 EAGKK--G---PEKVQPSLVKAAMVPIALIGEKYQYPPVNWAALLSPLLRLDFGDEVQQLCIKLAVtqAQSSQNAAMLLG 235 
XP_038026105 1375 ESGKK--G---PESVPAQLLKVALAPIAIVGESHQYPPVNWASVLSPLMRLNFGDEVKHLCLELAVtqAQSSQNAAMLLG 1449
7_pfamImport  161 EAGRK--G---PEFFPPDGIKVVLAPLATVGDNFQYPPVNWNAILSPMMRLNFGEEVQHHCLELAAnqAQSSPSAALFLG 235 
3_pfamImport  161 EAGKKdpG---PEFAHPALVKSVLTPLASVGASFQYPPVNWSAVLSPLMRLSFGEDVQHQCVRLAAcqVQSSQSASLFLG 237 
XP_019204834 1377 EAGQT--G---PQSSHPGLVKTALTALASVGASFQYPPINWSAALSPLMRMSFGEDVQHQCVVLAAcqTQSSHSAALFLG 1451
6_pfamImport  161 EAGRK--G---PDEVRPPPVLTALSSLASVGARFQLPPINWGLPLAPLMRLGFGEDVQHECLALAAsqAPWSQSAAVFLD 235 
XP_011604804 1372 EA-----GkkgPDFVHPVLVKTAVTSLASVGAGFQFPPVNWSVSLSPLMRLGFGEDVQHQCLVLAAsqAHSSQSAALFLG 1446 torafugu
E7FGT5       1381 EAGRK--G---PEFTAPQRVKTLLSALAAVGADFQYPPVNWSSVLSPLMRLGFGEEVQHYCLELAAsqTQSSQSASLFLG 1455 zebrafish
XP_064410830 1376 EAGKK--G---PETIPSQMIKVILGSIATAGSSYQYPPVNWAAILSPLMRLNFGEEIQRHSIEIAVtqAQSSQSATMFLG 1450 coelacanth
XP_028908675 1412 mwVIPPLVYSLSVKSRKYLFGSLSLWMKYVSVEQLQVFTKVFIVQHFEAKNRDQNPELCQESLEGLSQAMKIPNPAQHLW 1491
8_pfamImport  234 --LNPLLCKLLKLKTRAYLYKSVSVWMKHVPDDKLQSFVEVLGVQHLTASSRQQSPDLCVAVLEGLEQAMKLPNPTQFCW 311 
XP_007498129 1451 mwVVPPLIHSLNLKTKKYLLASLPLWMKHVSEDQLQVFTEVFMVQLFEASLAVQDPELCQSALQGLSQAMKLPSPAQYLW 1530
1_pfamImport  236 mwVAPPLVYSLSIQAKRYVFTSLPVWVKYVADDKLQAFTEIFMVQHFDTKKQAKNRELCWDILQGLHQAMKLPNPAQGNW 315 
XP_038026105 1450 mwVAPPLVYSLSVKTQKYLLVSLPLWMKHVAEDKLQSFTEVFLTQQFEMKSHTKETEICQCVLQGLMQAMKIPNPAQYCW 1529
7_pfamImport  236 vwLAPPLVHSLSLRTRALLYECLCSWMKHVAEDKLQVYVESLAVQQFNPDTRAQRHPLCLAILQGLAKAMSLPNPAQNCW 315 
3_pfamImport  238 pwLSPPLVHSLSYQTRALLFESVGLWMKHVSEDKLQVHLESLGLQQFQEDLRPQRLALCRSLLQGLAVAMALQSPPNNCW 317 
XP_019204834 1452 swLSPPLVHSLSYQTRAHLYETLGSWMKHVTEDKLQVYVESLGVQQFQEDLRPQRASLCCSVLRGLAQAMALPNPSSSCW 1531
6_pfamImport  236 swLSPPAGPQSQGATRAHLYESLGSWMRHVGEDKLQAFVEQLGVQLFREE---RAAPVCQALLRGLAQAMALPNPPKHCW 312 
XP_011604804 1447 swVSPPLVHSLSHPTRVHLYESLGLWMKHVAEDKLQVYVDKLGLQHFQDKQNPHSLSMCQSLLRGLAQAMALPNPPKHCW 1526 torafugu
E7FGT5       1456 vwLVPPLVHSLSLRTRAHLYESLSCWMKHVAEDKLQVYVDSLAVQQFEPLTRLQRLSLCLSILHGLSRAMTAPNPPQNCW 1535 zebrafish
XP_064410830 1451 mwLTPPLVHSLSMSTKKYLCSSVSLWMKQVPEDKLQLFAKKFGAQYFTAGNRHQNPDFCQVILEGLSQAMELPNPAQFCW 1530 coelacanth
XP_028908675 1492 NPLCQAAEKIFDILPNKIQRNEVDLYVMIAKCLAEMTDAEINRIFRITESNIEKTVFVRVYLISQGRFSLMSLNNVIDAV 1571
8_pfamImport  312 GVLRSTTERIFMLLPDEVQDDEVELYVRIATCLSEMEDTEIDRITRVTKANLVKTGFTMAYLVSQGRVPLLGLNDVIAAA 391 
XP_007498129 1531 SQLCWATEKIFDLLPNKIRRSDVDLYINAAKCLSEMTDAEIDRITHITKNNIKKAAFVKVYLVSQGRFPLMHWNDVIEVA 1610
1_pfamImport  316 SCLCKATERIFELLPNEIR---VKMYINSAKCLSEMTDTEVDQITQVSKNNLEKITFVKLYLVSQGRFPLLRWNDVISTA 392 
XP_038026105 1530 SFLCQAAEKIYELLPNEIQRGELEMYVSVAKCISEMGDSEIDRIVQISKNNIEKAIFTKLYLISQGRLPLMNLSAMIYAL 1609
7_pfamImport  316 SSLCTTTEKIYNLLPDHIQPSEVELYEGICSCLSEMSDTEIDRIVKVTEANVEKTTFILSYLSSKGRIPLLGLNDIISTV 395 
3_pfamImport  318 TILCSTTEKIFTLLPNNIQDNEVDLYVGISKCLSEMSDAEIERVTRVQETQMEKTCFVLAYLTSQGRVPLLGLNDVIAGV 397 
XP_019204834 1532 TILCSATEKIFTFLPDRIQDNEVDLYVGVAKCLSEMSDTEIERIMKVSETQMEKTCFILAYLTSQGRVPLLSLNDVIAGV 1611
6_pfamImport  313 ALLCSTTEKIYSILPDPKQEDEVGLYVGLARCLSEMSDTEIERITRVTEAGMEKSCLVLAHLTSEGRLPLLALNDVVAGA 392 
XP_011604804 1527 TVLSSTTEKIYSILPNQIQDNEVGLYVGLAKCLSELCDTEIDRITRVTEDRMEKAAFILAYLTSKGRLPFLGLNDVISGI 1606 torafugu
E7FGT5       1536 SVLCSTAEKIYNLLPDSIPAAEVALYEAMCSCLSEMSDAEIDRIVKVSEANVEKTAFILSYLVSKGRVPLLGLNDVISTI 1615 zebrafish
XP_064410830 1531 SILCKTVEKIFELLPNKIQRSEVELYIKLSKCLSEMADTEIDRITQVSKDNIEKATFIRAYLVSQGRVPLLSLNDILGTA 1610 coelacanth
XP_028908675 1572 LECDQRETVAWMILHSFY-HARIVSHPNTGVLKRLEWMLELMGIIRSVAYQSKPVQ--NVTLEKAVDFLFQIFAALVVAW 1648
8_pfamImport  392 IGSCHQEAVSSLLVRSFY-QSRLAASPNTGVLKRMEWLLELMGHIRNVAYGSTPVE--NGDVKQATDFLLQLFCAAVVSW 468 
XP_007498129 1611 VRCQDRETVAWMMLHGLY-HARIISHANTGVLKRMEWLLELMGYIRNVAYKSTSVE--NVALEEAINFLLLLFAASVVAW 1687
1_pfamImport  393 AGCQEKETIVWMLLHSFY-HARIVSHENTGVLKRMEWLLELMGYIRNVSLKTTSVP--NVAPKEALSFLVWIFAAAVVAW 469 
XP_038026105 1610 TGCYQKESIAWMFLHSFY-HARIVSHENTGVLKRMDWLLDLMGYIRNLAFKSTPIQ--NVDLKEFIDFLLWLFAASVVAW 1686
7_pfamImport  396 LQKGKTERISWLFLQCLY-QSRLASSPNTGVSKRMEWLLELMGHIRKVTYGA-SVK--CNRVREGTDFLLEVFAAAVVSW 471 
3_pfamImport  398 LRGWPSRRVGWLLLQTFY-QCRLATSPNTGVSKRMDWLLELMGHIRNVAYGATSVT--IGDTKLATDFLFQVFAAAVVSW 474 
XP_019204834 1612 LRGWPSRRVGWLLLQTFY-QCRLATSINTGISRRMEWLLELMGHIRNVAYGVTDVQ--CGDTRSATDFLFQLFAAAVVSW 1688
6_pfamImport  393 LRGWPSRRVGWILLQALHrHHHRAAKPGTGVSQQMGWLLELMGHLRSVTCGGSSHL--RGDASAATDFLFQVVAGAVVAW 470 
XP_011604804 1607 RCGWPGHRVGWILLQAFY-QCHRGTNPSTGVSQQMEWLLELMGHIRNIAYGG--KAepSGDTSAATDFLFHVFAAAVVSW 1683 torafugu
E7FGT5       1616 LQVGSKRPISWLLLQGLH-QSRFASGPNTGVSKRMEWLLELMGHIRNVAYGSPSVK--CVDVLQGTDFLLGVFAAAVVSW 1692 zebrafish
XP_064410830 1611 VRCNQTEAVSWMLLQCFY-QARLIAHQNTGVMTRIEWLLELMGHIRNVASGTTPLE--NTDLKRAVDFLLQIFAVSVVAW 1687 coelacanth
XP_028908675 1649 GDHATPLLLGFSASWLSWHKEHGessFAACSPNYLGHSPLNRLTLKETLTLLPNSMHLLLTKEPWKEHTPKFIDWLFNIL 1728
8_pfamImport  469 ADHSLPLLLGIGAKWLPWKEDNA---VPSSPQARFGNSSADEQLALQCSKGLPYSIQLLLAKEPWKGQTHKFIDWFFSIL 545 
XP_007498129 1688 GDHDAPLLLGLSASWLPWHHEGG---VAGSSPGYLGQSPNNKVTLQETLTLLPSSMLLLLSKEPWKEQTQKFIDWLFSIM 1764
1_pfamImport  470 ADHAAPLLLGLNADWSLWEGKA----VPGVSPSLLGRQPIDNLAVQETLTLLPGSLQTLLSKEPWKEQTHKFFDWLFSIM 545 
XP_038026105 1687 ADHGAPLLLGLSASWSSWNHQTV---LPELSKDHIGKHSTDKIAVQETLTLLPSSIFLLLAKEPWKEQTQKFIDWLISMV 1763
7_pfamImport  472 ANHSTPVIVGVRAQWFPWRQFSAe--YPDVPRGLYVNSVSTDESVKQCVLAVPYALKLLLDKEPWKSQSQKFIDWLFSIT 549 
3_pfamImport  475 GDHSMPLLFGIRAQWFPWQSDSK---PQTVRHGLYGEESLTERALPQCLLGMSCSLALLLAKEPWSSQTHKFIEWLFTII 551 
XP_019204834 1689 SDHIMPLLFGIRVQWFPWQPDPK---PHALTHGLYGEESLVEGALSQCLLAMSHSLPRLLDKEPWSSQTPKFIDWLLSIM 1765
6_pfamImport  471 GDHVVPLLLGLGARWLPWQPQAR---PCFPEH---GQEARAEEALAQCLPGMPLSLARLLSTEPWSSQTDKFIDWLLTIT 544 
XP_011604804 1684 GDHVVPLLLGVRATWLPWQPESK---PQILEHSLYGEESHVGNALPHCLLGMPLSLAQLLSKEPWSSQRHKFIDWLLSIT 1760 torafugu
E7FGT5       1693 ADHGGPLLVGIRARWFPWPQSAE------LCHGLYANPEDTELPVASCLLAIPYSIRKLLDKEPWKSQSQKFIDWLFSIT 1766 zebrafish
XP_064410830 1688 ADHTTPLLLGVSANWFPWKQEEAk--TANCPVNFLGCCSLNVLSVQGCLTVLPCSIQLLLAKEPWKEHTQKFIDWLFSIW 1765 coelacanth
XP_028908675 1729 ESPKEALSASTRDILKATLLALRFLPECKRKVVWTKVCGW 1768
8_pfamImport  546 ECPKQGLSERSIRTVKGALLALRYLPEFKKKVVWTRAYGW 585 
XP_007498129 1765 ESPQEALSSSSRDLLKATTLALRFLPEFKKKVVWSRAYGW 1804
1_pfamImport  546 EASNEVLSKSSRDLLKASLLALRSFPEFKKKAIWTKAYGR 585 
XP_038026105 1764 ESPKEALSKSSTDLLKATLLALRSLAEFKKKAVWTKAYQW 1803
7_pfamImport  550 EAPEEVLSPTAISTARAALLALKSNPEFKKKTVWTRAYGW 589 
3_pfamImport  552 EGPDQTLSATTVSTAGAALLALKSSAEFKKKAVWTRAYGW 591 
XP_019204834 1766 EAPEQSVSASTVSTAKAALLGLRSSAEFKKKAVWTRAYGW 1805
6_pfamImport  545 EGPEQSFSVGVVATAKASLLALQSFPGFQKKAVWTRAHGW 584 
XP_011604804 1761 EGPEKSFSVAVTNAAKAALLALNSVPEFKKKLVWTRAYGW 1800 torafugu
E7FGT5       1767 EAPKQAFSETAVLTAKAALMALRSSSEFKKKTVWTRAYGW 1806 zebrafish
XP_064410830 1766 ESPKKVLSETSKNVLKATLLNLRFLPEFKKKAVWTRAYGW 1805 coelacanth
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