Conserved Protein Domain Family
Hva1_TUDOR
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pfam11160: Hva1_TUDOR (This model is not part of the current CDD release)
Hypervirulence associated proteins TUDOR domain
Family members include Cryptococcus neoformans HVA1 (hypervirulence-associated protein 1) whose absence is associated with a hypervirulent phenotype in mice. Metabolomics analysis suggests that when HVA1 is absent there is a block in the citric acid cycle, while structural analysis of the Hva1 protein suggests a potential interaction with NADPH. The structural architecture of Hva1 bears similarity with Tudor domains.
Links
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Statistics
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PSSM-Id: 519618
Aligned: 161 rows
Threshold Bit Score: 39.4175
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006459055   7 GDRVKYHAVGGrssgtdtsTTTGEIVDVL---TEPQPAGEtgVTAKASEDEPRYLIRNDnTGKETAYKGTNI 75 
XP_005649067  18 GDFVSTKYRGG--------TREGVVERIA---KTPEEH----------PHPPKVIFTNQ-RGKEVAHNPSTL 67 
XP_013269465  15 GDTVATPYRGG--------KHEGKVEQII---TDEEEARK--LDAKGASHAPAVVFTDQ-NDKKVVHKPETV 72 
XP_003029106  17 GDTVASKARGG--------RQYGEVTDIV---TTKEEAEE-----AGAKNPPKVLYEDQ-HGHLVSHNPGTV 71 
XP_008031681  40 GDHVYTRIRGG--------RHEGNVDKVV---TSEEEAASegV-----KNPPKVLFTDQ-KGKNVAHNPSTL 94 
XP_018255856  16 GDHVWTRIRGG--------RHEGDVERIV---TTAKDAEKe--EVKNP---PKVLFEDQ-HGHRVAHNPGTL 70 
XP_040763800  16 GDEVFTRIRGG--------THEGKVEAVLrteEDIKNAGDlgITVKHP---PKVIFTDQ-HGHRVSHNPETL 75 
KZT27257       7 GDRVKTRFRSG--------KREGVVQKIVt--SEPQDTSDlpVDVKHP---PKVLV--S-HGHMASHNPGTL 62 
XP_007867296  17 GDKVGTKFRGG--------RREGLVEKIVt--SDSQDTSDlpIDVQNA---PKVVFKDQ-HGHTVSHNPGTL 74 
KIL64075      18 GDVVSCRARGG--------KQFGEVTDIVd--RQEAEEKGv-------AHPPKVIYVRH----TVSHNPKTL 68
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