Conserved Protein Domain Family
Pho86

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pfam11124: Pho86 (This model is not part of the current CDD release)
Inorganic phosphate transporter chaperone Pho86
Pho86p is an ER chaperone required for chaperoning multi-pass membrane proteins through the ER membrane compartment. It is essential for growth when phosphate levels are limiting, being involved in the regulation of Pho84p, a high-affinity phosphate transporter which is localised to the endoplasmic reticulum (ER) in low phosphate medium. When the level of phosphate increases Pho84p is transported to the vacuole. Pho86p is required for packaging of Pho84p in to COPII vesicles. This entry also includes the Uncharacterized protein C12B10.02c from S. pombe, which is thought to be an orthologue of S. cerevisiae Pho86.
Statistics
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PSSM-Id: 519610
Aligned: 28 rows
Threshold Bit Score: 170.176
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003683190  14 EQVDASLNEPLNMEAPPTIYGTTIKPELATAALNLAIDFIKQQQSLANRGMIHHYITKIVMTVVAIIYLTPQATIPRNlR 93 
XP_001385214   3 IQKVVDLNKPLDADAKATLEKSSLKPELAQAALALHGDRYRQLQSRLNRFLFWHPVFIIVFSIAIPTVLTYKLWDYIS-I 81 
XP_002547371   3 VQKELDLNKPLDSNAAPNLGKTILTPELSKSAIVLHGDRYKQLQAKLTKYVLWHPYAMLAMTTVVPIIFFYSVWDYVS-I 81 
XP_036663639   3 TQKDIDLNTPLDARAPSTLSKSALTPELTKAAVTLHGDRYKQSQANLTRFIIWHPYSLALYSLIFPSILVYALWDYIS-I 81 
XP_007374656   3 IQKEVDLNEPLDAHEAPTLSKTPLKPEFAKAALILHGDTYKQLQAKLNRFIFWHPIAIIAYFLLIPAALLYNLWDFVE-V 81 
XP_006689467   3 IQTKIDLNKPVKSAPDPKLEVVALRPEFSEAALLLYGDYFRQCQTTLTKSILWHKQVVSIGLGVVSAYLYYILADYIE-V 81 
Q6BUK3         3 IQKDVNLNEPLNDKIPPTLGKTSLTPELSQAALILQGDYYSQLQGKCNRYVFWHPISTTFLVISTSIFTYYRLYDYIS-V 81  Debaryomyces ha...
CCE86712       3 IQKEVNLNVPLDVNKKATLSRTELTPDLAEASLVLHGDYYRQLQGKCNKYLFWHPLSLFILISGGLSFFLFRVREWIE-V 81 
XP_001484353  17 AQKFVDLNEPLNPEAKPTLAKSSLTPEYAEASLILHGDYYRQLQGSCNRYIFWHPISMSIWVVGLVAAAAYFLRDYYA-I 95 
Q10436         5 QRKRIDIRRP-------TLAELSSIRSIAMNALNGQSRNLSQK-------IFWHPLYLAVFGLVFMG------------- 57  Schizosaccharom...
XP_003683190  94 AGSVSGFLyQLFMFN----WYPMATTAAIASVAFVCLLTTYSRISETFFKSRIHE------VAKDSGHSTFGIDLRELV- 162
XP_001385214  82 SDSPVELLsFLIKSNd--fRFQILASLPLLAAVMGFVGITCFWVSEELRYISDKM------IQEGFAGEIFGFNIKTFSe 153
XP_002547371  82 SENLLEFY-HLVKKDkkdfIFSILSAFPLFASIFGIFGFLAYIVGEDMG-IASKN------FAQKYCDYVFGFNIRAFAk 153
XP_036663639  82 SDNLVELY-FIASRNkrdfIFHIIKSGPTIAGIFGIFGFIAYILGDEVGAITDRY------VAQKYCDYTFGFDVKEFA- 153
XP_007374656  82 SDSAWEFF-LLGKKNpkdfIYGIIAAFPMVAGIFATFGLITYIMGDDIGNITSAF------VAQKYCDKVFGFDIKKFAq 154
XP_006689467  82 SESVGEFFsIAIHSAd--lKVNILFTSAVILGFIAFVGLISVMISDEFRIISENL------VKKSYVEDVFGFDLVKYSk 153
Q6BUK3        82 SESFGEFFsFFIKSRd--fQFQVMGIFPWLVCVFGIVGIVTHFVSDVYKDISVKL------PQLKYIEKIFGFNLKEYAr 153 Debaryomyces ha...
CCE86712      82 ADSIGEFFkFFIKSRd--fQVEIFKTFPLAISIFGIIAVIAFMLSDVFRVISDDL------PKPEYSHALYGFDITKFAn 153
XP_001484353  96 SNGLLDFFaQFVARSd--mKFELIYLLPCTVLIFAFIGLSAHLLSDDLRDIADKL------DQPDRIEELYGFDLRKFAk 167
Q10436        58 ---------IYRLTNmvegNTKLRTFVLLILVSAVFLTLIEFPCRNVYAKISTEDnqpdgcLAEENLKHFYMARID---- 124 Schizosaccharom...
XP_003683190 163 -LKSKPV------LKDPQ-----AQNTYVVVYREAPIALISLTENKTLTSKESLVMSVSTIGCRKVYLKSGIIEDMLDWA 230
XP_001385214 154 lPSEPTttqdv-------klyenGVNTQIILYRDSPIAICTVTPDLVNSTVENFIVKISGLHIRKVFAKVDFDDLLIDWS 226
XP_002547371 154 ----NDnnedk-------klaklGQNTELIIYRESPIAVGSLVVDEDQSTVENFVVKITGVHVRKVFQKVDFDEVLIEWA 222
XP_036663639 154 -------------QDPKTpllknGKNSELIIYKDQPIAIGTLKPDWEQSTPDNFIVNITGIHVRKVFKKVDFDQLLIEWA 220
XP_007374656 155 lTGHETdvdsi-------kllkkGLNTQIIMYRESPIAICTVVVDEEQSTPESFIVEITGLHVRKVFENVDFHELLIEWA 227
XP_006689467 154 lEGDSKvlkek-------kilanGSNSQVVLFQEQPIAIITLKPIYDKSNDSHLVIKVSGLSVRRVFKPLNFEQILIEWA 226
Q6BUK3       154 lSQSTLlkqkrklTPKEVvflknGANTHIVMYRDSPIAIITLIPLLDESSETEFVIKITGLHVRKAFVKVDFDVLLLEWS 233 Debaryomyces ha...
CCE86712     154 sgemklT------PKEKAaf--hGDYTQIIIYRDSPIAVITLRPLLDVSTDSNFVVRITGLHVRKVFAKADFETLMLEWS 225
XP_001484353 168 eDPNSr------lSPKQKallqnGENTHLIVYRNSPIAVITLKPLLDNSTEANYFVRITGLHVRKVFVKADFHTLLIDWA 241
Q10436       125 --------------------------------KERVIGIIGILPANAPGAYQNTPTIVHWTVIPKFYQYA---FDLLDSA 169 Schizosaccharom...
XP_003683190 231 MLRTKTL--A-KENN------HGESMKVLIDVYSFDDHMKKTLKAKGFSPVASAKIKESRL------------------- 282
XP_001385214 227 IFRAREIyqDyVKSK---------NLKIVVDSYSFDKKFESTLLAKNFVIVDESLELNPYkevst--------------k 283
XP_002547371 223 ILRTRELyqEfLVSNglkappENSSILITADTYSFDPEFQKTLQENGFRPIDVSFQLNPFdsavy--------------g 288
XP_036663639 221 VLRARELyqEyLLQKks--ktKNGTIFVVTDAYSFDKEQEGTLIRCGFKLLSSSLELNPFspslk--------------s 284
XP_007374656 228 VLRTRELyeEyAKQKkv--ktQEGTILITTDAYSFDKRLQTCLYNTNFGVMSKDVELNRFsdtln--------------k 291
XP_006689467 227 LSRSNDLltEyLKAKkvk-ktSGCKVSLLVDCYTFDTEFAKFLESNRFNKIDSTYNYNPIgeita--------------p 291
Q6BUK3       234 YDRARDIlkEyGPNKd-------AKITLLADAFSFDNLLIKTLENQSFQKISSSFTLNSFEddsesktgi------lsyi 300 Debaryomyces ha...
CCE86712     226 FTKARQIfqQhVKKSk----vAGCKIQLLIDAFSFDRFYINALTKNSFGKVSSSYVLNPMVaketkksdkpvssqgilak 301
XP_001484353 242 LLRSRQLfhEySKKKsd---vDSCKINILVDAYSFDKTYIKFLQSRSFGRVSSSTLLDkskkgs---------------n 303
Q10436       170 LREAKEMgaDvVSAR----------------VYSTDPML-KAFERKDFTPVVDEAFD----------------------- 209 Schizosaccharom...
XP_003683190 283 ----L-GGLFGFQKELWGVQF 298
XP_001385214 284 iqklI-HSFFGVSRRTLELDI 303
XP_002547371 289 fkerI-YKFLNVCRITFGLML 308
XP_036663639 285 yekfL-NRLLGISRDTFGLLL 304
XP_007374656 292 pkeiL-HKLLGVSRDTFGLAL 311
XP_006689467 292 lkglL-NKTFRSGRDTYGVHI 311
Q6BUK3       301 tstgA-YKTFGITKDTYRLTL 320 Debaryomyces hansenii
CCE86712     302 issmLtHKVFNISRDTYGVTI 322
XP_001484353 304 liqsL-NKLLGITRDTFGVTI 323
Q10436       210 ----Y-LSFFGLRRLVLQKNL 225 Schizosaccharomyces pombe 972h-
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