Conserved Protein Domain Family
CENP-M

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pfam11111: CENP-M 
Centromere protein M (CENP-M)
The prime candidate for specifying centromere identity is the array of nucleosomes assembles with CENP-A. CENP-A recruits a nucleosome associated complex (NAC) comprised of CENP-M along with two other proteins. Assembly of the CENP-A NAC at centromeres is partly dependant on CENP-M. The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival.
Statistics
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PSSM-Id: 491620
Aligned: 12 rows
Threshold Bit Score: 267.306
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_001017175   1 MATLRPFDKMPMLNAAALLLVGTEESHREQLASAMLKE-PKTFEVKIHMAQSLPLPYEREHLRPRFDMVVFLINLHSQFS 79 
2_pfamImport   1 MALLRPLDKLPTLDVATVLLLGTEETLLQQLGAAIIEEcEGTAKIQVHMASSLPLPSDRECFRPRIDLIVFVLSLHSKYS 80 
Q1T7B9         1 MAVLRPFDKLPELNSATILLVGAEGGPQQQLAEAMLRE-KKDFNINIHLASSLPLPSERDHLRPRIDLIAFVIDIKSKYS 79  chicken
XP_005039726   1 MAVLRPFDKLPMLNSCVILLVGSDEAIQQKLAEAMLQE-KRNFNVSIHLATSLPLPSERDHLRPRIDMVVFMIDIKSKYS 79 
Q9CQA0         1 MSVLRSMDKLPDLNRATVLLVSTEDALLQQLAESMLKD-DCASELRVHLANSLPLPSNVN--RPRIDLIVFVINLHSKYS 77  house mouse
Q2TBH1         1 MSALRPLDKLPGLNTATILLVGTEDALLQQLADSMLKA-DCTSELKVHLARSLPLPCSVN--RPRIDLIVFVVNLHSKLS 77  domestic cattle
XP_002721428   1 MSVLRPLDKLPGLNTATVLLVGADDALLQRLADSMLKT-DCASELRVHLARSLPLPSNVN--RPRVDLLVFVINLHSKYS 77 
XP_006011016   1 MSVLKPFDKLPELNTATVLLVGAEEHYLEKLAEIIAKE-TQPFKINVRTAKRLPLPTENDYIRPRIDLIVFIINLHNKQS 79 
XP_003447922   1 MSLLKPFSKLPGLNTANILLVESEEQFQQSLADALVE--ETSVTVNVRLAKSLPLPMENDESRPRIDLVVFIINLTSELS 78 
Q7ZZC6         1 MALLSPYSKVPELNTATVLLVENEEELQNKLANAIVQH-EKDFNVNVRLAKKLPLPVENKEARPRIDLIVFIVSLLSERS 79  zebrafish
XP_030840712   9 QPVLHPFNKLPELNSAVVLLIGFQSIKKKELAEAMVAL-NTEFCLQVRTATQLPLPSINDEQRPKIDLIVFILDVNVNMS 87 
XP_048575943   4 EVVLSRFGKLPTKDHGTALFVGIKGIGKHRLAQTINEC-NTEFPLQIRTATALPLPNDHQNLRPRIDYVTFFIDLENKLS 82  starlet sea ane...
NP_001017175  80 LSTVLASLTHLDVNFFLGKVCFVAIGGGQVKHCMVDIATVKKLAD------------THLSTLLFSEFDSEDDVTCTARR 147
2_pfamImport  81 LKTVELSLPHVDASFFLGKVCFLVTGARNEQNNGVHLDTVKKMAA------------TYHSPLLFADLEVKCFRVSMAQR 148
Q1T7B9        80 LKNVQASLAYVDVRFFLGKVCFLVTGVGRANNCSVEMNAIWKLGE------------DYCSPVIFCELELEGIRVATAQR 147 chicken
XP_005039726  80 LKNVETSLAHVDASFFLGKVCFLVTGVGRVNACSIETNAVCKLAE------------AYCSPVLFCELELEGVRAATAQR 147
Q9CQA0        78 LQKVEEFLQHVDSSFFLGKVCFLVTGAGQESHCSVHQNTVIKLAH------------TYRSPLLLCDLQVESFRAAMARR 145 house mouse
Q2TBH1        78 LQSVEESLCHLDAAFFLGKVAFLATGAGRDSHCSIHRNTVVKLAH------------TYRSPLLFCDLEIEDFRAAMAQR 145 domestic cattle
XP_002721428  78 LQSVEKSLHHVDASFFLGKACFLATGAGRENLCSVHRNTIVRLAR------------TYRSPVLFCDLEVEGSRAAMAQR 145
XP_006011016  80 LSVVESALAFVDVKFFLGKVCFLATGVGMVKYCSVEAYSVRKLAE------------SCCCPVIYTELESRKERESTAQR 147
XP_003447922  79 FQSAEASLKYLDPGYFLGKVCFMVTNARNASSPAERLDAVRKLAS------------SLHCPLLFAEDQTPDGVASATER 146
Q7ZZC6        80 LQSAESSLSHLHSDCFLGKVCFLVTDARCGSHTQERLVSVRKLAA------------SHHCPVICAEHRTADGVSAAALR 147 zebrafish
XP_030840712  88 LKTVADSLPHLDPTYFLGRVCFLALNAPSEKTQCADLGDILALCD------------AYDSPLICGDLETQEQRESLARR 155
XP_048575943  83 FDVVKLSVKSLAVDYFLGRCCFILTNAKKEECNNVDIQDVIEFANvydspiicadlkS------------KDGQRCLAQK 150 starlet sea ane...
NP_001017175 148 LLQMVQICAGLVP-GISALYLGSFMNST 174
2_pfamImport 149 LIRILQICAGHVP-GLSALNLLSMMKGS 175
Q1T7B9       148 LLRMLQICAGRVP-GVSALYFSLLMRNS 174 chicken
XP_005039726 148 LLRMLQICAGHIP-GVSALSLVSLMRN- 173
Q9CQA0       146 LVRILQICAGHVP-GVSALNLMSLLRSP 172 house mouse
Q2TBH1       146 LVRLLQICAGHVP-GVSALNLLSLMRGS 172 domestic cattle
XP_002721428 146 LARMLQISAGHVP-GVSAMSLLSLLRSS 172
XP_006011016 148 LVRMLKISAGFVP-GVSALFFSSLLKTS 174
XP_003447922 147 LLTILKVAAGLVP-IATALYVSNLTRCT 173
Q7ZZC6       148 LLNILQVSAGMTPmSTTALYLSTLTRCS 175 zebrafish
XP_030840712 156 LVEMTEIAAGFKN-GISPLLIQSTRRSY 182
XP_048575943 151 LLQRIKPACGYHG-DVTPLLLDTTRQIF 177 starlet sea anemone
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