7KZS


Conserved Protein Domain Family
FANCF

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pfam11107: FANCF (This model is not part of the current CDD release)
Fanconi anemia group F protein (FANCF)
FANCF regulates its own expression by methylation at both mRNA and protein levels. Methylation-induced inactivation of FANCF has an important role on the occurrence of ovarian cancers by disrupting the FA-BRCA pathway.
Statistics
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PSSM-Id: 519603
Aligned: 23 rows
Threshold Bit Score: 215.683
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7KZS_F        26 MESLLQHLDRFSELLAV-SSTTYVSTWDPATVRRALQWARYLRHIHRRFGRHGPIRTALERRLHNQWRQEGGFGRGPvpg 104 human
6_pfamImport   1 MEVVLGQVEQLPALLAV-SRSALVRDWDSLTLDRALEWARYFQHLYDRFRTRPQLREALGRRLRRSQPYP---------- 69 
XP_030129162   1 MDAVLRQVEQLPALLAV-SRSAQVRHWDCLTLDRALEWARYFQHLHHRFRARPQLREALGRRLRRSQPLP---------- 69 
XP_012823448   5 MHTLLENLDRYIEVLTL-SQSVHVKDWDISCVRRGFEWGTYFQQVYHRFHTNECLRNALEDHLRSKNETLSACIKNYq-- 81 
XP_006011742   1 MEALLENLTRFCEVLAV-ARSDYVSEWDSRTLHRAFQWADYFQHICGRFGANAPVREALERRLRLANESLSRNFEGYr-- 77 
7_pfamImport   1 MEAVLKNLGSTLEVLAV-SETEFVREWDARTVDRAFQWAKYCEHVYNRFHANPSIRPVLEDCLRLTNERLSEGLSGHr-- 77 
XP_005809971  10 MEAVLKNVGCTVELLAVaAHSGVVNEWDEQTVTRAFHWARYCEHIYSRFHGNPVIRGVLEKQLQLTNHRLKEAFPEYn-- 87 
XP_020559646   1 MEAVLKNVASAVELLAVaAYSDAMSQWDEKTLSRAFHWARYCEHVYTRFHTNSAGRRVVEKQLQHTNARLRDAFADYr-- 78 
5_pfamImport   1 MEAMLKNLASTVEMLAVaAQSDAVKHWDKQTLSRAFHWARYCEHVFSRFHNNAAIRRIMEKQLQLTNQTLRDTIPGYt-- 78 
2_pfamImport   1 MEAVLKNVAGTAELLAVaSLSGEVERWEEPTVSRAFQWARYCEHLCRRFHDNPAIRRVIEKQLRVTNHGLRAAFAGYg-- 78 
7KZS_F       105 LANFQALGHCDVLLSLRLLENRALGDAARYHLVQQLFPGPGVRDAD-EETLQESLARLARRRSAVHMLrf-------nGY 176 human
6_pfamImport  70 QLGFSTLGRCPQLLGLALLENRALPPAACRRLLRSLPRSPGAGTGP----EPRGLELIARRKAAACLLals-----rlPP 140
XP_030129162  70 VLGFPALGRCPQLLGLALLENRALPPAACRCLLRSLLQPPAGGSGR----DPGGLPLLARRKAAACLLas------gpGP 139
XP_012823448  82 YITFNDLRYSKEIFCMSLLQNKALSKDIFQYIVRQLK-----NLSS-GEISICSMSNIMCQKAALQLLlfs-----ssIA 150
XP_006011742  78 FLSFEALRRCGETLRLSLLGNPAVSQSLYPRVLAGLE----------DRASLEDLRRAVGQKAAARVLfeagaasrsrTP 147
7_pfamImport  78 ALSLADLAQCRHRLFIGLLRNPLAPHSVFKSLFDNCRLFEDDGDTKpGRETHLDLSGLIMCRSACKLLgsf-----qlNS 152
XP_005809971  88 AVSFLDLGRCQDLLLLWLLNNSALPISIMKMLFETKA-SADSTSSD-YEDVRGLCNQIIQCKSACTVLr---------PL 156
XP_020559646  79 EVSFMDLPRCEHLLLLALLSNPHLPISTMKILFGKKD--VASRYYD-YKEVTGLCSHLIQCKSACKVLc---------PF 146
5_pfamImport  79 EVSFSDLPRCQHLLLVRLLNNPELPSSLMKMLFDTAR-PVKTMHGE-YEDVTGLCSHIVQCKSVYKVLs---------PL 147
2_pfamImport  79 DVSFSDLYRCQHLLLVGLLKNPQLPISVMKILFDA-------EQSE-YQEVTGYCSRIIQCKSACKVLs---------PL 141
7KZS_F       177 RenpnlqEDSLMKTQAELLLERLQEVGKa-----------EAERPARFLSSLWERLP-Q-NNFLKVIAVAL-LQ-PPLSR 241 human
6_pfamImport 141 Rrl--pgPEAQLQAEAQLLLRRLQEEAQei---------pEAAGQLRWLCGVLEQLP-Q-PRAFEVVAAALvLLkQGRGQ 207
XP_030129162 140 Q--------GQLQAEARLLLGRLREEGQgaeaqllreegqETAGQPRWLRGALEQLP-Q-PRACGVVAAALaLLaQGCDT 209
XP_012823448 151 Skn--plENPCVVTQAEILKNHLENRIRl----------lKGDHQFAVVADVLSGIP-Q-PSVYKILAVLL-LSsETCDS 215
XP_006011742 148 Del--pgADPVARTDAALLIQYLNDRQRrl---------dSSGDRERLVEVALGKLAgS--QLWPVLAAVL--------- 205
7_pfamImport 153 Qet--sdISFSTQVQGLMLLQRLHAIQChp---------gNDSYLRKLMDTFLQDVGqDlDHLFEVIAACL-LIeNETSE 220
XP_005809971 157 Lgv--psVGADAEVQGEMLMERLGSALSqs---------sDPRRVEDFLSSVLQEFEvAaEHLCPVIAAAL-LT-TDSAV 223
XP_020559646 147 Sgl--saVDADAEVQGEMLMKRLDALLSqg---------sDPQQAEHFLHSVLLLSEeAaHHSCLVITAAL-LTaSDSGT 214
5_pfamImport 148 Adm--saLGADAEVQGEMLMERLEALLNqg---------sETCRAEHFLGSVLQGCEgAlQQFCVVIAAAL-LTsKNCAA 215
2_pfamImport 142 Ads--saVGADAEVQAEMLMERLGALLSrg---------gEAR---HILDSVPQGFEgAaGHFCVVIAAAL-LMkKNS-- 204
7KZS_F       242 RPQeElepgi----------hkspgEGSQVLVHWL----LGNSEVFAAFCRaLPAGLLTLVTSRHPALSPVYLGLLTDWG 307 human
6_pfamImport 208 GRDgSsldgyqa-------saagdgCTAELLLSWL----LGSQERFSAFCLcLPCSYLAFLAGHYSQLSRSYLDLLTVWG 276
XP_030129162 210 EQTgDadraasssqggyqagaagdgCAAGFLLSWL----LGNQERFSAFCLcLPSSQLAFLAGHYSQLSRSYLDLLTSWG 285
XP_012823448 216 QGQv---------------------SLSHLFLKWL----LENDSAWTDFCSkINCHLLSRLSSKYVIVSKAYMDFLIKVG 270
XP_006011742 206 ----Tdda---------------ggVAVDLVLSWL----LGNGGQLQAFCTcVHCILLTEIASRHPRFRAAYLQVLTEWG 262
7_pfamImport 221 EHTa----------------------AQDFLLDWLqdhhQNHHSLLQTMCQsLPLQMCTKLSQKQKKIRLMYWEVLKQWA 278
XP_005809971 224 QTA-----------------------SQDFLLDWL----QSRRGVLQHVCTaLPSKVLADLAERHQKFRDAFCKLLKKWA 276
XP_020559646 215 QTS-----------------------SQSFLLNWL----QKEHGMLQHMGStLPSAVLKDLARAHGKFRDAYFSALKKWA 267
5_pfamImport 216 QTA-----------------------AHDFLLDWL----QKNHSLLQHMCSlLSPTLLRDLAKEHQKFRDAFCNVLKKWA 268
2_pfamImport 205 --------------------------SQDFLLDWL----QKEQSVLEQMCSsLPSALIIELTKKQPKFRDAFCDLLKKWA 254
7KZS_F       308 QRLHYdlqkgI-WVGT--ESQDVPWEELHNRFQSLCQAPPPLKDKVLTALETCKAQDGDFEVPGLSIWTDLLLAL 379 human
6_pfamImport 277 SHLVYdplqgR-WVKSclDEAELSWEELRQRFSCLCQGSTLLKEQTQAALKLLRTQDGDFKVCGVSVWTDLLME- 349
XP_030129162 286 SRLVYdplqgR-WVKSclDKAELSWEELRERFICLCQGPALLREQTQAALELLRTRDGDFKVRGLSVWTDLLMEV 359
XP_012823448 271 ESMELdv-hgK-WVSS---NAELPFNTFRNHFESLMNTSEDLRSATEAKLKALKSQDGDYDLPGISIWTDILLEV 340
XP_006011742 263 ESMEYmpsggRgWMSS---LPGLDWGKLLKHFSSLIKGPKAVQEATESTLQTLKAQDGDFNEWGISVWTDLLLAL 334
7_pfamImport 279 SSMEYdvsggV-WVQQcdTFP--SFKTLVNHLKSIWRSGSPLKEETEKELVVLKQVDGDFEVQGLSVWTDLLLHV 350
XP_005809971 277 SEMEYrvtegE-WVHAa-TNSAVSFQKMTEHYLTLFEACPSLRTEVEDELNAQRIADGDFDVRGLSVWGDILLAL 349
XP_020559646 268 SEMEYslndgE-WLPEg-TAPSLSFQEMVEHFSDLFDACPSLRRNAEDELLALKILDGDFDARGLSVWGDILSEL 340
5_pfamImport 269 SEMEYslndsE-WVLTs-TGPTVSFKKLTELFLALFEASPSLKGGVEKELNALKISDGDFDVTGLSVWGDLLSAL 341
2_pfamImport 255 SDMEYslsegE-WIQTr-RNPTVSFDRLTEHFLGLFETCPSVRVDVEEELNALKMSDGDFDVRGLSVWGDLLSVF 327
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