Conserved Protein Domain Family
DGF-1_5

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pfam11038: DGF-1_5 (This model is not part of the current CDD release)
Dispersed gene family protein 1, region 4
This entry represents a presumed domain present in DFG-1 from Trypanosoma species, whose exact function is not known. It is one of the most abundant proteins in T. cruzi genome and it seems to have a preferential expression in amastigotes (intracellular replicative forms that develop in the mammalian host). It is likely to play a role in cell-to-cell interactions or signal transduction. This domain precedes the transmembrane segment at the C-terminal and based on structure predictions, it may adopt a Ig-like fold.
Statistics
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PSSM-Id: 519583
Aligned: 4 rows
Threshold Bit Score: 215.895
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_029241116  120 AGGGLTQNDIRSGGgNAPIRLMVALPPPFRWASDPQLGTRLSFVQGSAAQPNGLSGPWGALLRSATWLRNATHPFAVLEL 199 
XP_029237622   95 SGRGLTLADIRTSS-AAPKKLTVALPPGFRWARDTDLRPYLSFALASVAQPEGFSGQWGTMLRNATWERNATNPHAVLEL 173 
Q4CZ77       2856 PGRGLTLEDIRLSG-ATPKKLTVALPPPFRWERDADLRPYLTFALASLMQPNGYSGPWGEKLRNSTWERNRTNPRGVLEV 2934 Trypanosoma c...
XP_802205     285 AGGSLTQNDIRGGGsAVPTLLMVALPPPFRWARDPQLGTHLSLVLVSTAQPSGFGGPWGAMLRNATWVRNATNPSTVLEL 364  Trypanosoma c...
XP_029241116  200 AVPVYGGYFIGADETIIVRCDAEAVLGGCRGVLLGSFTVTS 240 
XP_029237622  174 TLPVDDRYFVGVDEKIVLRYVPRALHGGCSGMLQGEFTITS 214 
Q4CZ77       2935 TVPKDDKYFIGMDEKILLAYTPHALHGGCTGVLEGAFTINS 2975 Trypanosoma cruzi
XP_802205     365 AVPVHHGYFIAADETIVIRCDAAAVSGGCKGVLLGSFTIRS 405  Trypanosoma cruzi
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