Conserved Protein Domain Family
Musclin
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pfam11037: Musclin (This model is not part of the current CDD release)
Insulin-resistance promoting peptide in skeletal muscle
Musclin is a muscle derived secretory peptide which induces insulin resistance in vitro. It encodes a 130 amino acid sequence including a NH(2) terminal 30 amino acid signal sequence. Musclin expression level is tightly regulated by nutritional changes.
Links
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Statistics
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PSSM-Id: 519582
Aligned: 8 rows
Threshold Bit Score: 180.398
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_012402138   1 MLDWRFVATHLILAIFLMQWSTGKGPGVEAAP-EQAInSIAENAQSHIENTEEKSATELTQKLLFLDELVSLENDVIETK 79 
NP_001092067   1 MMDWRLASVHFILAVTLMLWSSGKVLSMDVTT-KAFD-SELIDVEPPPTMTEEKSATDLAAKLLLLDELVSLENDVIETK 78 
XP_006637936   1 MLGCRCILLPCLFAVTLLHWSKGILQLAEGAP-EFLDsSLVEAADSRSLSSDEKSSNDLAAKLLLLDELVNLENDVIETK 79 
XP_005992527   1 MLECKLIFLHCLLAVTLLQWSGEKFLLAEGAP-ESFDsSMLSEID----SSEEKSSSDLTAKLLLLDELVSLENDVIETK 75 
XP_004834833   1 MLDWGPAGAHFILAL-LVLWSSGKVLSVDATT-EAFD-SVITDVQSPPTARREKSATDLAAKLLLLDELVSLENDVIETK 77 
P61364         1 MLDWRLASTHFILAMIVMLWGSGKAFSVDLAS-QEFG---TASLQSPPTAREEKSATELSAKLLRLDDLVSLENDVFETK 76  house mouse
XP_028924269   1 MLESRLVIVHFIFAVILMPWSAGTALLVDAEP-ESFD-SVAEAMQSHSASSEEKSSTDLETKLLLLDELVSLENDVIETK 78  platypus
P61366         1 MLDWRLASAHFILAVTLTLWSSGKVLSVDVTTtEAFD-SGVIDVQSTPTVREEKSATDLTAKLLLLDELVSLENDVIETK 79  human

XP_012402138  80 KKRSFPVFGAPLDRLSAGSFNVKGKQRKTVDLPKRRFGVPIDRIGSNRLANTRG 133
NP_001092067  79 KKRSFSGFGSPLDRLSAGSPDHKGKQRKVVDHPKKRFGIPVDRIGRNRLPNSRG 132
XP_006637936  80 KKRSFPGFGSPLDRLSVNNMELKGKQRKVVDLPRRRLNVPIDRIAMNRIPNSRG 133
XP_005992527  76 RKRSFPGFGSPVDRLSVSSMDLKNKPRKVVEPPKRRFGVPIDRIGTNRLANSRG 129
XP_004834833  78 KKRSFPGFGSPIDRLSAGSVDHKSKQRKAAHHSKRRFGIPVDRIGRNRLSNSRG 131
P61364        77 KKRSFSGFGSPLDRLSAGSVEHRGKQRKAVDHSKKRFGIPMDRIGRNRLSSSRG 130 house mouse
XP_028924269  79 KKRSFPGFGSPLDRLSAGSVDVKGKQRKVVELPKRRFGVPVDRIGANRLANTRG 132 platypus
P61366        80 KKRSFSGFGSPLDRLSAGSVDHKGKQRKVVDHPKRRFGIPMDRIGRNRLSNSRG 133 human
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