Conserved Protein Domain Family
SnAPC_2_like

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pfam11035: SnAPC_2_like 
Small nuclear RNA activating complex subunit 2, SNAP190 Myb
This family of proteins is snRNA-activating protein complex subunit 2 (SnAPC subunit 2). SnAPC complex allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element, the TATA box. The family functions both to specifically recognize the proximal sequence element present in the core promoters of human snRNA genes and to stimulate TBP recognition of the neighboring TATA box present in human U6 snRNA promoters.
Statistics
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PSSM-Id: 402569
View PSSM: pfam11035
Aligned: 15 rows
Threshold Bit Score: 248.877
Threshold Setting Gi: 972956859
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001923727   1 MKPPRRQRTVPSRFHKtpeqEqidSARSLCkgWNRKDLHSFLQALkQQQDFESEIDLTEIQK-KIPQR---SLKQIENLI 76  zebrafish
XP_005332194   1 MKPPQRRRAAPARYLG----E---VTGPAA--WSPREKRKLLRLL-QARRDQPEPDSAELAQ-ELRGR---SEAEIQAFL 66  thirteen-lined ...
Q91XA5         1 MKPPQRRRRVPARYVG----E---ATGPTA--WSPREMRHLLRLL-QARRGQPEPDAAELAQ-ELRGR---SEAEICRFI 66  house mouse
EHB04242       1 MKPPQRRRSAPARYLG----E---VTGPVP--WSLREKRXXX-----XXXXXPEPDAAELAR-ELWSR---SEAEIRDFL 62  naked mole-rat
Q3T0I6         1 MKPPQRRRAIPRRYLV----E---VTGPAA--WRASEKRQLLRLL-QARQGQPELDAAELAR-ELPGR---SNTEIQDFI 66  cattle
XP_003123246   1 MKPPQRRRAAPARYLG----E---VTRPAA--WSAREKRQLLRLL-QARRGQPEPDAAELAR-ELSGR---SDAEVQDFL 66  pig
XP_008107661   1 MKPPSRPRSAPARYHL----------GPVSriWTDREKRRLLRGL-RAQAQAPGPLRLEVLKkYLPSR---GEDEIMKFV 66  green anole
XP_001376853   1 MKPPLRRRAAPARYRGlapaA---VRTGSL--WTPREKQQLLRLL-QALDGETEPAAAELRQ-GLPHR---SEAEIQDFL 70  gray short-tail...
XP_023352683   1 mkppvrrraaparyrGlaptG---VRTATL--WTAREKQQLLRLL-QAQDVEREPAAADLRQ-GLPHR---SEAEIQDFL 70  Tasmanian devil
XP_003421329   1 MKPPQRQRVAPARYLG----V---ATGPAA--WSVREKRQLLRLL-QARRGQPEPNAAELAR----GLpgrSEDEIQDFL 66  African savanna...
XP_001923727  77 NKVKLRVLQKVFKQVks-----qRKKERKAKVPIETWGEMVQKISTSHGKTISAAFSQMLVVAATEPCSLMHSEPPhpvt 151 zebrafish
XP_005332194  67 QQLKDRVVREAIQRVhpg---gpKRREAEPPAPIEVWMDLVEKITGPLEEALTAAFSQVLTIAATEPVSLLHSKPP---- 139 thirteen-lined ...
Q91XA5        67 QQLKGRVVREAIQKMqpggregpRHQGTPLPAPVEVWMDLAEKLTGPMEEALTAAFSQVLTIAAAEPLSLLHSRPG---- 142 house mouse
EHB04242      63 QHLKGRAVREAVQRVhpagplgpRRRQAQILAPIEVWTDLAEKITGPLEDALTAAFSQVFTIAATEPLSLLHSTPP---- 138 naked mole-rat
Q3T0I6        67 RQLKGRVAREAIQRIhpggpkgpRRWETQTPAPIEVWMDLAEKITGPLEEALTVAFSQVLAIAATEPVSLLHSVPS---- 142 cattle
XP_003123246  67 RQLKRRVAREAIQRMypggpqglRRQEAQPPAPIEVWMDLAEKVTGPLEESLTVAFSQVLTIAATEPISLLHSKPP---- 142 pig
XP_008107661  67 DLLKERVAKEVVKAQfry--hqcKQKDAPVPAPIEVWTALAEKMTGCLEDAVTAAFSQVLTIASTEPLCLLHSVPP---- 140 green anole
XP_001376853  71 QSLKRRVAREVIQQEhrccqkeqRLHKTQVPAPIEVWTDLAEKVTSQLEEAMTTAFSQILTIAATEPVSLLHSIPE---- 146 gray short-tail...
XP_023352683  71 QSLKRRVAREVIQQEhhccqkeqRCPKAEIPAPIEVWTDLAKKVTSQLEEAMTTAFSQILTIAATEPVSLLHSIPK---- 146 Tasmanian devil
XP_003421329  67 QQLKGRVAREAIQRLhpggplgrRR---QTPAPIEVWMDLAEKITGPLEEGLTAAFSQVLTIAATEPLSLLHSQPS---- 139 African savanna...
XP_001923727 152 qtpvfsrlypahtpnttsrpttsgvSPSSSVSTASA-VSFIRPDSSssaaghigksdtvssslhqepVMPEAS------- 223 zebrafish
XP_005332194 140 -------------------------KPTQARGKSLI-LNITGGQGD---------------------TTPEAP------- 165 thirteen-lined ...
Q91XA5       143 -------------------------KPTKARGKALVfLSNQDGQKD---------------------PASEGS------- 169 house mouse
EHB04242     139 -------------------------KPTKARGKPLL-LSAIRRQEDrspvasgpaleapgpapvasgPAPGVPdlvpgpe 192 naked mole-rat
Q3T0I6       143 -------------------------KPTQACGKPLL-LRAPGGQED---------------------LGPEAS------- 168 cattle
XP_003123246 143 -------------------------KPTQARGKQLL-LSAPGGQED---------------------KGPEAP------- 168 pig
XP_008107661 141 -------------------------KPMEVKTTRCS-------------------------------------------- 151 green anole
XP_001376853 147 -------------------------KPTQASERQLL-CKDSNPQEE---------------------LPPEAP------- 172 gray short-tail...
XP_023352683 147 -------------------------KLTQASERQLL-CQESHSQGE---------------------APPQAP------- 172 Tasmanian devil
XP_003421329 140 -------------------------KPTQARGKLLL-LNTPRCQEAsnp----------------gvPVPDTPgv----- 172 African savanna...
XP_001923727 224 ----TPTSsssqsqseae----------------aavsspvssrPSPSTSSNKPSpisLEllghdypcKPRImksvVNFD 283 zebrafish
XP_005332194 166 ----GPAS------------------------------------ETPAKSPNGPA---VK--------GDIT----MDFE 190 thirteen-lined ...
Q91XA5       170 ----GPVPmtaadptreasvsdpkasganpetsglasevtvpdpDAPTKSLAGSS---TE--------RDLA----VDFE 230 house mouse
EHB04242     193 piisGPAPvasgsalclsg---------------papkasgptpEAPAESLAGPS---PE---------DLT----FDFE 241 naked mole-rat
Q3T0I6       169 ----SPAPeapgggevpg----------------stlktpgpapEASSESLAGQS---AE--------GDFS----VDFE 213 cattle
XP_003123246 169 ----GPAPkvqg-----------------------------papEASSESLAGPS---AE--------GEFS----VDFE 200 pig
XP_008107661 152 ----SPTLhnknks-------------------------neetrEATVSSNGEELtpvKN--------GEFQ----VDFE 190 green anole
XP_001376853 173 ----KPTQeascgvp-----------------------gtcdteVKTSHSECSSA---TN--------RNFV----IDFE 210 gray short-tail...
XP_023352683 173 ----EPTQetsggds-----------------------gpsgtpDKTDSSKSGPAa-pTN--------GNLV----IDFE 212 Tasmanian devil
XP_003421329 173 --peAPVPdt---------------------------------pEAPSKPPSGPS---SK--------EDFT----VDFE 202 African savanna...
XP_001923727 284 KIYAYLSDMDSKTCSSALSSMECAVLLDLLMCLPEELPLLDCKGLQHHLLQLHSQLSKPTVK--PESYSNG--PLsgeAN 359 zebrafish
XP_005332194 191 KIYKYLSCCSRGGHVPELSAAESAVVLDLLLSLPEELPRLPCTALIEHMTKTYAHLMAPQPS--PSGRSPG--PG---AE 263 thirteen-lined ...
Q91XA5       231 KIYKYLSFSSRGGHGPELSAAESAVVLNLLMALPEELSHLPCTALLEHMTKTYAQLMAPQTAl-PGEKRPR--PG---TE 304 house mouse
EHB04242     242 KIYRYLSFSSRSGHGPELSAAESAVVLDLLLSLPKELPHLPCTALVEHMTKTYAHLTAPEPS--PSGGSPG--PG---AE 314 naked mole-rat
Q3T0I6       214 KIYTYLSSVSHGGQGPELSAAESAVVLDLLMALPEELSRLPCATLVQHMSGMYRHLTAPQRD--LASGGLA--SG---TE 286 cattle
XP_003123246 201 KIYKYLSSISRSCHGPELSAAESAVVLDLLMALPEELSRLPCAALVEHMTDMYLHLMAPQPD--SANGSLG--SG---AE 273 pig
XP_008107661 191 KIYKYLSVISRGSKAPELPPGESAVLLDLLLSLPEELECLDFNKLKSHMYKCYRELNGRYTGnkNGTQAESs-QSvnsGR 269 green anole
XP_001376853 211 KIYKYLSSISRSGKGLELSPGESAVLLDLLMSLPEELSHLPCEKLQTHMASSYRKLVRPQAGssPGHSDPGqaPTvedDE 290 gray short-tail...
XP_023352683 213 KIYKYLSSISRSGKALELSPGESAVLLDLLMSLPEELSRLPCEKLQAHMAGSYRKLMRPQQPsdPSHGDPGkgPSvpdGE 292 Tasmanian devil
XP_003421329 203 KIYKYLASFFRSGPGPELSPAESSVVLDLLLSLPEELSHLPCTALAEHMTGAYLRLTAPEPS--LAKEGLG--PG---TE 275 African savanna...
XP_001923727 360 SSTS--------AQKPSAAAGSSEKh-------------gPVKDSEDWASAGICPLNPLSVPVTLLKRKSV 409 zebrafish
XP_005332194 264 DGSA--------CSQGPEEPSQTSShape--------qatPGEPRSAWQAAGICPLNPFLVPLELLGQAAT 318 thirteen-lined ground sq...
Q91XA5       305 DGGT--------GSTGPEEPDQASPqa-----------sePIEPRLAWKAVGICPLNPFLVPLGLVSQAPS 356 house mouse
EHB04242     315 DGRT--------GSRVLGEPGWVPPrvpe--------qngASKLRSAWRAAGVCPLNPFLVPLELLGQEAT 369 naked mole-rat
Q3T0I6       287 DSGA--------GSRGQEETGQASPqape--------nagSSQPISSWQAAGVCPLNPFLVPLELLRQVAr 341 cattle
XP_003123246 274 DGGS--------GSRGQEEAGQATPqape--------nagPSEAISTWQAAGVCPLNPFLVPLELLGQAAT 328 pig
XP_008107661 270 DQHDilfhihpnSSCCQQQEGANSHsssk--------ndeASSSAINWKTLGICPLNSFMFPLDLLTRKgd 332 green anole
XP_001376853 291 DGTS--------TSNGPGRMGSPSPespassglncprdtlPSGQQQLWQELEFCPLNPFLIPLELLSRAAP 353 gray short-tailed opossum
XP_023352683 293 GGTS--------GSRDPGSLESPPAespaa-----sgpspPSAQHQLWQDLEFCPLNPFLLPLELLSHRAA 350 Tasmanian devil
XP_003421329 276 DMDA--------GSRGHKEPGQATPqvse--------sagPSEPRSAWQAAGVCPLNPFLVPLELLGQAAT 330 African savanna elephant
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