Conserved Protein Domain Family
SNAPC2

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pfam11035: SNAPC2 
Small nuclear RNA activating complex (SNAPc), subunit 2
This family of proteins is snRNA-activating protein complex subunit 2 (SNAPc subunit 2). The SNAPc complex allows the transcription of human small nuclear RNA genes to occur by recognition of the proximal sequence element, the TATA box. The family functions both to specifically recognise the proximal sequence element present in the core promoters of human snRNA genes and to stimulate TBP recognition of the neighbouring TATA box present in human U6 snRNA promoters.
Statistics
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PSSM-Id: 491575
Aligned: 23 rows
Threshold Bit Score: 228.918
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_010903962   3 PPSRLRIKPTRFVskktdntgtkrkpkIAFTG---WSRTEQQILLRCLNSqskktagIHGA---IDLEALHAKLPKRSTE 76 
XP_021586638   3 PPQRRRAAPARYL--------------GEVTGpaaWSPREKRKLLRLLQA-------RRDQp-ePDSAELAQELRGRSEA 60 
XP_007532915   3 PPPRRRAIPARYL--------------GETTRppaWSAREKRQLLRLLQA-------RREQp-ePDAADLARELPGRSAE 60 
XP_001376853   3 PPLRRRAAPARYRglapaa----------vrtgslWTPREKQQLLRLLQA--------LDGetePAAAELRQGLPHRSEA 64 
XP_001923727   3 PPRRQRTVPSRFhktpeqe--qidsarSLCKG---WNRKDLHSFLQALKQqqd----fesE---IDLTEIQKKIPQRSLK 70 
1_pfamImport   1 PPPRNRTKRELSSwtetpk-----scrktNC----------------LKAlsqttrgGLQE---IDYAVLKKDIPTRSIS 56 
2_pfamImport   1 PPPRKRSKPELSTpp-----------------------------------------------tkMYFLFGNRRVDSVFPG 33 
5_pfamImport   1 PPPRKRGKPNRPTptegpr-----------kpprrWNKTEEKTLLNALQKlgr-talADGDtdnIDYSFLGKRLPKRSVA 68 
KPP78294      39 PPSRPRAVPQRFQtkqtesqrpprmrsVWCT----WRAVERRHLLAGLRRqss--------kaeVDLDALQKKLPKRSVQ 106
XP_002722053 106 PPARRRATPARYVee----------vtG-PQA---WSPREKRQLLQLLQA-------RHGQp-ePDAAELAQELQSRSET 163
XP_010903962  77 EIQSQLECLMMRVLRSVVIQV-----KSQRSEQKVAMKPIQQWAELAHDMAG-ALEEPITSAFAQMLVISATEPGSLKNS 150
XP_021586638  61 EIQAFLQQLKDRVVREAIQRVhp---gGPKRREAEPPAPIEVWMDLVEKITG-PLEEALTAAFSQVLTIAATEPVSLLHS 136
XP_007532915  61 EIQTFIELLKSRVVREAIKRLrp---gSPPPEDRQTPAPIEVWLDLAEKLSGpPLEEALSTAFSQVLTIAATEPLSLLHS 137
XP_001376853  65 EIQDFLQSLKRRVAREVIQQEhrccqKEQRLHKTQVPAPIEVWTDLAEKVTS-QLEEAMTTAFSQILTIAATEPVSLLHS 143
XP_001923727  71 QIENLINKVKLRVLQKVFKQV-----KSQRKKERKAKVPIETWGEMVQKIST-SHGKTISAAFSQMLVVAATEPCSLMHS 144
1_pfamImport  57 EISAMVDSLKNNIISSARFQL-----RMKNWQEKQFRRPIEEWTHMASTLAG-TLEKVISAAFSQMLVVSSTEPCTLRNC 130
2_pfamImport  34 QIQSEVDSLKDKVISSASFEF-----ERRRRQERKVKKPIELWTDMASSVTG-SLEETINTAFAQVttnsiss------- 100
5_pfamImport  69 EIRSVVDALKDKAISSAALKL-----RRRKRDEKVARKPIEEWANLASTLAG-SLEGTVDAAFSQVLIVSSTEPCTLRNC 142
KPP78294     107 EISSFLEFLKGRVGRCVVHRV-----WSQKREERKEKVPIQLWSDLAKTMVG-SLEEAISSAFSQVLVIGATEPCSLLHS 180
XP_002722053 164 EIRNFLQKLKARVVREAIQRVhpdgpQGARRREAQPPAPIEVWMDLAERVTG-PLEGALTTAFSQALTIATTEPTNLLHS 242
XP_010903962 151 DPPREgyiskpqssnlktiparpi--------------------------ptpvsvtppahpralnspTGaiskyGGNTs 204
XP_021586638 137 KPPKP---------------------------------------------------------------TQ-----ARGKs 148
XP_007532915 138 KPPKT---------------------------------------------------------------TK-----AREPq 149
XP_001376853 144 IPEKP---------------------------------------------------------------TQ-----ASERq 155
XP_001923727 145 EPPHPvtqtpvfsrlypahtpnttsrptts-------------gvspsssvstasavsfirpdssssaAGhigksDTVSs 211
1_pfamImport 131 EPKQDprpaaacrp------------------------------------------------------------------ 144
2_pfamImport     --------------------------------------------------------------------------------    
5_pfamImport 143 DPPRDnksstsfgppvrivplkpasrpptpvfskspa------------------------------------------- 179
KPP78294     181 DPPHHisiseltesslhtilpkpkitstsndklrtmgpsngaepppkdplqgtavvavtpsthqlsptLVssgpsEESEs 260
XP_002722053 243 RPAKP---------------------------------------------------------------TQ-----ARAKp 254
XP_010903962 205 ----------------sIPsth-----------------------qsNHPTVTVSPvAGdvstrql-------------- 231
XP_021586638 149 lilnit----ggqgdttPEa---------------------------P---------GP--------------------- 167
XP_007532915 150 lflsap----agqkeatAQtdgpapgvpgpapeacgsthgapgpaleSSGPAPGAP-GPalessgpapgapgptlkfsgp 224
XP_001376853 156 llckdsnp-qeelppeaP-------------------------------------------------------------- 172
XP_001923727 212 slhqepv----mpeastpT----------------------------SSSSQSQSEaEAavssp---------------- 243
1_pfamImport 145 --------vpcvgcqnsNQed------------------------ppTlpv----------------------------- 163
2_pfamImport 101 ----------ggldcffMSlh------------------------iiKQQISSPPSsAPspaasps-------------- 132
5_pfamImport 180 --------------------------pstgpsrtlpapsptprvpqnvvrppqekpgtPspttpdp-------------- 219
KPP78294     261 iispspahanqpaadqnHL----------------------------KKKPSSSPQpDPpvqe----------------- 295
XP_002722053 255 lllsap----ggpqdpaPE----------------------------VPGPAPETS-GPa-------------------- 281
XP_010903962 232 ----plaasgsS-ASsgpaAAGARPTHQ----HTsagprrskhadgntprytGLGCIVDLEKIYRFLSTIHIQSECFKLT 302
XP_021586638 168 -----------A-SE----TPAKSPNGP----AV------------------KGDITMDFEKIYKYLSCCSRGGHVPELS 209
XP_007532915 225 tpgapgpalesSgPApgapGPAPESSGP----AL------------------PGPLTVDFEKIYKYLASVSRGNQGPELS 282
XP_001376853 173 -------------------KPTQEASCG----VPgtcdtevktshsecssatNRNFVIDFEKIYKYLSSISRSGKGLELS 229
XP_001923727 244 --------------vssrpSPSTSSNKP----SPislellghd---ypckprimKSVVNFDKIYAYLSDMDSKTCSSALS 302
1_pfamImport 164 ---------ssF-SSphstVPLSNTAAE----LPatsgqsskhaavdgpetvGVNFAVDFEKIYKFLSVVQNPSKDYNLT 229
2_pfamImport 133 ----isslistL-ATkptpPPPSSPAAA----LPaglgrscml-kedspriiGVKCVVDFERLYRYLSVILKPDEECHLT 202
5_pfamImport 220 ----paspsseI-QTgpppSPDIPSASTsalaQPsssdagseqkapnpqrvmEVKQIVDFERIYKFLSVVHKPEEESRLT 294
KPP78294     296 ----------gtnTGfegpSQRDTSSSQ----LPasaqqp------sqnkpkEKDYIVNFENIYHFLNALNKKAKEPILT 355
XP_002722053 282 -------------PE----APSKSSSGP----SLa-----------------EGDFPVDFEKIYKYLASFSRGGQAPELS 323
XP_010903962 303 PMESAVVLDLLMSLPEELPLLDCARLQHHLLE----VHkrfsapvpkaaqgrictgkstslneegtkaedqgrpvghrgg 378
XP_021586638 210 AAESAVVLDLLLSLPEELPRLPCTALIEHMTKtyahLM------------------------------------------ 247
XP_007532915 283 AAEAAVVLDLLQALPQELPRLPCGALTEHLLDayahLT------------------------------------------ 320
XP_001376853 230 PGESAVLLDLLMSLPEELSHLPCEKLQTHMASsyrkLV------------------------------------------ 267
XP_001923727 303 SMECAVLLDLLMCLPEELPLLDCKGLQHHLLQ----LHsqlsk------------------------------------- 341
1_pfamImport 230 PMESAIVLDLLMSLPEELHYLDCKNLQKHLIQ----MHqslsaphcs--------------------------------- 272
2_pfamImport 203 PMEGAIMLDLLMSLPEELPQLDCKELQKHLKQ----VNlrdrvvk----------------------------------- 243
5_pfamImport 295 SMESAIVLDLLMSLPDELPLLDCNGLHNHMMK----MYscltasadsvaatqll-------------------------- 344
KPP78294     356 PMESAVVLDLLLSLPEELRLLDCQALQSHLRQ------------------------------------------------ 387
XP_002722053 324 ATESAVVLDLLLSLPEELSRLPCVALAEHMAQ----MY------------------------------------------ 357
XP_010903962 379 ndegetpvttpphqavrdaavapletlpkspvdgeqdvsirgmpdgqgsdgaessltnqdaastaasgnlvagcsdfsae 458
XP_021586638     --------------------------------------------------------------------------------    
XP_007532915     --------------------------------------------------------------------------------    
XP_001376853     --------------------------------------------------------------------------------    
XP_001923727     --------------------------------------------------------------------------------    
1_pfamImport     --------------------------------------------------------------------------------    
2_pfamImport 244 --------------------------------------------------------------------------aadsqs 249
5_pfamImport 345 -----------------------------------------------------------------selkdggggqtgeqr 359
KPP78294         --------------------------------------------------------------------------------    
XP_002722053     --------------------------------------------------------------------------------    
XP_010903962 459 DGaalapgSTQeRVGSETFTPLQASGHDQGQPLLpndTSVKSGKAKQRk--AD---------WKKAGLCPLNPFVVPLKL 527
XP_021586638 248 AP------QPS-PSGRSPGPGAEDGSACSQGPEE---PSQTSSHAPEQatpGEpr-----saWQAAGICPLNPFLVPLEL 312
XP_007532915 321 AP------QPH-LDMGSPEPGSEDAGAPSQAPEDtg--------------pGApg-----taWQATGVCPLNPFLVPLGL 374
XP_001376853 268 RPqagsspGHSdPGQAPTVEDDEDGTSTSNGPGRmgsPSPESPASSGLncpRDtlpsgqqqlWQELEFCPLNPFLIPLEL 347
XP_001923727 342 ---------ptvkpESYSNGPLSGEANSSTSAQKpsaAAGSSEKHGPVkdsED---------WASAGICPLNPLSVPVTL 403
1_pfamImport 273 ----------------------mpakqlmskEAEtgdAAGRGATSSGQsedAD---------MSDFL-PPLNPFLVPLSL 320
2_pfamImport 250 SEssnat----------------------------------------sqqdAD---------VPGVC-PPLNPFMVPVKL 279
5_pfamImport 360 DEassgtaAEEvQPP--------------------------AGSSSSQsqdSN---------QCKTV-PPLNPFMVPLSL 403
KPP78294     388 ------------------------------NLADaesSLASPSLGPGAgqkAD---------WSTVGLCPLNPFMIPLKL 428
XP_002722053 358 NRlt--apEPSlAEGGPAGESPPGESPAEAGGEAg--RGQASSQGPEGtgpSDlr-----stWQAAGICPLNPFVVPLEL 428
XP_010903962 528 LARrTVQPVE 537
XP_021586638 313 LGQ-AATPTR 321
XP_007532915 375 LGQ-VDTPVR 383
XP_001376853 348 LSRaAPPEGL 357
XP_001923727 404 LKRkSVDCDK 413
1_pfamImport 321 LMRkMCDPQR 330
2_pfamImport 280 LKCrKVPLQT 289
5_pfamImport 404 LVRkAENTDG 413
KPP78294     429 LARsAMIPVV 438
XP_002722053 429 LGR-VASPAR 437
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