3IV4


Conserved Protein Domain Family
BrxC
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pfam11009: BrxC (This model is not part of the current CDD release)
Monothiol bacilliredoxin BrxC
Bacillithiol (BSH) functions as a general thiol reductant, analogous to glutathione, in a wide range of bacterial species. Bacilliredoxins reduce those proteins that are modified by disulfide bond formation with BSH (S-bacillithiolation). This entry represents BrxC from Bacillus subtilis (formerly known as YtxJ) and similar bacterial proteins related to BSH. BrxC is a monothiol bacilliredoxin responsible for the removal of BSH from oxidized cytosolic proteins. It can also debacillithiolate the mixed disulfide form of the bacilliredoxin BrxB. It has a similar fold to thioredoxin. The homologue in Deinococcus radiodurans, named AbxC, plays a role in the response to oxidative stress.
Links
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Statistics
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PSSM-Id: 519573
Aligned: 62 rows
Threshold Bit Score: 115.34
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3IV4_A          9 IKLSSIDQFEQVIEENKY--VFVLKHSETCPISANAYDQFNKFLYER-D--XDGYYLIVQQERDLSDYIAKKTNVKHESP 83  Staphylococcus...
unil:wcw_1330   1 ------mQLKSLLEENQAktFFIFKHSTRCPVSAMAFAEFERFSGKHqE--VICAFVKVIEHRDVSDLIAELTGVVHQSP 72 
WP_013182273    8 yELTTPEEVDSFLSVNPN--CALFKAGG-CHKTMQGFGVVEKMMGSRgE--LPVGLVKVIDHRPASNHIAELTGIVHESP 82  Waddlia chondr...
WP_012064730    6 KEIDTVEDLEKLIKKSHKkpVFIFKHDVAKQESEDVFQQYKDFIEENeEd-IMSTVVYVREDMEVSDAVEELLEVNHDTP 84  Alkaliphilus m...
8_pfamImport    1 QEISTLEAWDKVRSDSANrqIIVLKHSTRCPVSASALEEFEAYLADKpNpdTDYYLVKVIESRPVSNKIAEDLGVVHASP 80 
7_pfamImport    1 KEITTKEEWEQYYEGSGSkpFVVLKHSTACPVSFNALQEYEAYLGKTpNeqVDYILVKVIESRPVSNQIAEETGVKHASP 80 
Q9K8J3          4 KELTTVEQWQEVFEETTEtpVLVFKHSTQCPVSAEAHQELHALLENGlQwdGQVVLVKVIESRPVSNQIAEDLGVKHESP 83  Bacillus halod...
Q5WG62          3 EELTTEAEWQTFLQGSGDtlSLLFKHSTQCPVSAEAFEEYKQFANENnS--YRYGFVKVIESRPVSNKIAEDLDTVHKSP 80  Bacillus claus...
WP_012959174    2 KEITTDQEWHDLFKQSDDgpVLLLKHSTTCPISAEAYDEFQSFINSSnEnaHTYAMVKVIESRPVSNLISEELGVKHESP 81  Alkalihalophilus
CCG46724        7 NELTSQEDWQNVWKRSMDspILVYKHSTSCLISARAFKQLKTFQKSGeDe-IDCYMVKVIENRRVSNEIAKDTNISHKSP 85 

3IV4_A         84 QAFYFVNGEXVWNRDHGDINVSSL 107 Staphylococcus aureus subsp. aureus N315
unil:wcw_1330  73 QVFLFDKGELLWNASHSDIREESM 96 
WP_013182273   83 QFILFKEGKAVYDVDNWDIIPESL 106 Waddlia chondrophila
WP_012064730   85 QIILVIEAEVAWDESGNGITTDQL 108 Alkaliphilus metalliredigens
8_pfamImport   81 QMILVKDGKAVWNTSHWSVTKKHM 104
7_pfamImport   81 QVLYIKNKETVWNTSHWSITEEHL 104
Q9K8J3         84 QAIVVKDQEAIWNKSHWDIKQDTL 107 Bacillus halodurans
Q5WG62         81 QVFVLKNKSVRWTESHWNIKKQTI 104 Bacillus clausii KSM-K16
WP_012959174   82 QLFILDKKQVKWVDSHFSITKKKI 105 Alkalihalophilus
CCG46724       86 QILLIDKQQVVWNTSHWKITEKRI 109
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