Conserved Protein Domain Family
RDM
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pfam11002: RDM (This model is not part of the current CDD release)
RFPL defining motif (RDM)
The RDM domain is found on RFPL (Ret finger protein like) proteins. In humans, RFPL transcripts can be detected at the onset of neurogenesis in differentiating human embryonic stem cells, and in the developing human neocortex. The RDM domain is thought to have emerged from a neofunctionalisation event. It is found N terminal to the SPRY domain (pfam00622).
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Statistics
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PSSM-Id: 519571
Aligned: 14 rows
Threshold Bit Score: 59.3146
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006905496  54 MVSQKKEIRPNCQLGRLVSKVKKLEPQLRMILQMNPRIRKFQ 95 
6_pfamImport   1 VVSQKDDFRLNRQLGKLASTLKELEPQLRASLWMNPNIRKFQ 42 
1_pfamImport   1 VVTQKNDVRQNFQLHQLISNIKELEPQLRAILRVDPRMLKFQ 42 
XP_010586347  54 VVSQKDDIRSNFQLGKLISKIMELEPQMKKILKMNPRMLRFQ 95 
ELW64770     248 VVSQKEDIRSKSHLGELVSKIQELEPQLRAALQMNPRVKKFH 289
XP_003127523  54 VVSQKKDLIGARKLGELVSKVKDLEPHLTEVLRMNPRIRKLQ 95 
7_pfamImport   1 VVSQKTDLRSALQLRALVCKVK-LEPQLRAVPQMSPRIRKFS 41 
D4ABM4        54 VVSLKEDIRHAKQLRNLVTTVKDLEPQLNFILTMDPSMKIFQ 95  Norway rat
3_pfamImport   1 VVSQKDDITPNLQMGKLVSKVKELEPQLRVVLQMSPRMRMFQ 42 
4_pfamImport   1 VVSQESDIRPSLQLGKLVSRVMELEPQLRAVLQMNPRMRKFQ 42
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