This entry represents mitochondrial proteins from fungi, such as subtelomeric hrmA-associated cluster protein AFUB_079030 from Aspergillus fumigatus and YDR124W from yeast. Null mutant showed severe fragmentation of mitochondria and its expression is strongly induced by alpha factor. These proteins may have a role in maintenance of mitochondrial morphology. This entry represents an helical bundle domain which seems to adopt a similar arrangement than the EIN3-like DNA-binding domain (Based on structural comparison, DALI server). AFUB_079030 is part of the subtelomeric hrmA-associated cluster (HAC) containing genes that alter the hyphal surface (such as reduced total chitin or increased beta-glucan exposure) and perturb inter-hyphal interactions within the developing biofilms, resulting in a loss of vertically aligned polarised growing filaments.
Jiyao W et al.(2023). "The conserved domain database in 2023.",