Conserved Protein Domain Family
WYL_2

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pfam10902: WYL_2 
WYL_2, Sm-like SH3 beta-barrel fold
WYL_2 is a family of Sm-like SH3 beta-barrel fold containing domains. WYL is named for three conserved amino acids found in a subset of domains of this superfamily. These residues are not strongly conserved throughout the family. Rather, the conservation pattern includes four basic residues and a position often occupied by a cysteine, which are predicted to line a ligand-binding groove typical of the Sm-like SH3 beta-barrels. It is predicted to be a ligand-sensing domain that could bind negatively charged ligands, such as nucleotides or nucleic acid fragments, to regulate CRISPR-Cas and other defense systems such as the abortive infection AbiG system
Statistics
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PSSM-Id: 402476
View PSSM: pfam10902
Aligned: 52 rows
Threshold Bit Score: 63.0553
Threshold Setting Gi: 296096344
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6WI26         4 V-NIDDLLKNGKVTFEFEKADGTIKTVTGTRNLDFIPAEfhpkekplaEGETKPEKTEKQKATCGYFDLEANGWRSFKRA 82  Vibrio phage KVP40
VDO08683      44 CqHALEALGEGVVMLQYLKLDGTRRIAHGTLCKGISEAYdry----eyKGKSGVKKTEEGYFTFYYWDLDEEGFRSFNAA 119 Haemonchus placei
BAF73356       8 VlKIINDTNGKIFAVQFTKKDGTLRMMLARLgv-------------qkDLKGGNNGASEKNSLITVWDMVANGYRMVNLE 74  Sulfurovum sp. ...
WP_011965752  36 LyRLAKKMRTETVRFAYEKTDGSIRYTEGTLMNLPAGAT-----------VRGKRITKPSYKTFAYFDARKNEMRCFRIE 104 Bacteroides vul...
CBK66006      36 LyRLAKRMRSGEVKFAYEKVNGSIRYAIGTLKNVPAGAT-----------NKGKRMTKPSYKTFSYFDVDKQEFRSFKIE 104 Bacteroides xyl...
CDE64183      34 LyRLTQRMRAGVVRFAYEKADGTLRRAAGTLHEVAATIK-----------GTGR---PDDGCTVKYYDVEADGWRSFKVE 99  Alistipes putre...
WP_011966186  35 LyRLTKQMHRGIVTFAYEKADGSLRRAKGTLKDVQGLIK-----------GTG----SENYKTVRYFDVDANGFRSFKVE 99  Parabacteroides...
CDC98346      34 IeSLKEKLRSGVAHFIFIKKDGTVREAFGTTNAAVARKY-----------TNGNGCSRELYSTTAYFDIEKGAWRSLRWE 102 Alistipes sp. C...
CCX65378      35 IeNLKTKLQNGIAHFTFIKKNGELRECWGTTQPNLAKAK-----------TNGNGESRENYCTTAFYDVEKGTWRSFRWE 103 Prevotella sp. ...
WP_004338278   5 FeTLVWKLRRGIVSFVYRKKDGTERHACGTL----YGIG---------HTIKGTSKHHQYNYTFAYYDVDCKGWRSFIIE 71  Prevotella bivia
Q6WI26        83 NLR 85  Vibrio phage KVP40
VDO08683     120 RLD 122 Haemonchus placei
BAF73356      75 TLL 77  Sulfurovum sp. NBC37-1
WP_011965752 105 NLI 107 Bacteroides vulgatus
CBK66006     105 NLV 107 Bacteroides xylanisolvens XB1A
CDE64183     100 NFV 102 Alistipes putredinis CAG:67
WP_011966186 100 NFI 102 Parabacteroides distasonis
CDC98346     103 SIV 105 Alistipes sp. CAG:268
CCX65378     104 SLV 106 Prevotella sp. CAG:1058
WP_004338278  72 NLV 74  Prevotella bivia
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