5WSX,2PFC


Conserved Protein Domain Family
FcoT

?
pfam10862: FcoT 
FcoT-like thioesterase domain
Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.
Statistics
?
PSSM-Id: 491464
Aligned: 10 rows
Threshold Bit Score: 233.787
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5WSX_A        33 LVPYK-DHCKYLRSAVVTES----DTG---RA--------VARCEFAIPESCYIDDTGHLNSVEVNICYNQMMYYLVAKS 96  Streptomyces av...
WP_015209316  22 LEPYK-ENCKYLKKAQVQYS----NVGipkKSqkvdeaewIIKGEFSIPDSCYIADTGHFNAVEFNICYNQLCYILMAYL 96  Cylindrospermum...
WP_012831083  31 LTPYM-TPCKYLKSVDISYDpsasNGVlpaKL--------RARGRFSIGESCYIEDTGHFNAVEFIMCFNQIGYVLLAHA 101 Haliangium ochr...
WP_025360886   9 LLPYK-QDCSYLRSAEIT-V----ESG---LA--------TGRGRFEIPQSCYIEDTGHFNSVEFNICYNQLVYYVMASA 71  Kutzneria
WP_014173120  28 LRPYR-TNCRYLGPAEVRLEne----------------avTASGTFRIGESCYIDDTGHFNAVEFNICFNQIAYYLIAKC 90  Streptomyces
WP_014987674  17 LHCYK-PHCRYLRTLEVRSSge----------------kvTATGTFEIPESCYIDATGHLNSVEVNICYNQMLYQTIAVM 79  Nocardia brasil...
P9WM67        30 LEPYScKGCRYLIDAQYSATed----------------svLAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPA 93  Mycobacterium t...
Q9CBG3        30 LEPYSyKGCRYLIDAQYRASpd----------------svFAYGNFGIEESAYIRGTGHFNAVELMLCFNQLGYSAYAQS 93  Mycobacterium l...
WP_012823830  24 LSVYF-DNTRYLKSANIFLD----DNGaksRI--------VSHGKFSVPESCYIESTGHFNSVEFNICYNQIMYDAIAHA 90  Halothiobacillu...
2PFC_A        30 LEPYScKGCRYLIDAQYSAT----ED----SV--------LAYGNFTIGESAYIRSTGHFNAVELILCFNQLAYSAFAPA 93  Mycobacterium t...
5WSX_A        97 VKEGLLAGFESWTLDDFWKHQLPDILIARFASNFRRPVNPRAFSGEMEFQSVTRRAPagg-ipFLHAETAYRYWDADSGR 175 Streptomyces av...
WP_015209316  97 VDNKLLDAMKHWDLKTYKERQLSNCLIAKFSSTFKKQINARQFQGLLAINKSSFRGN------LIILKTSCVFYDEYEGW 170 Cylindrospermum...
WP_012831083 102 LQAGLVRGVPAWGREDFAERQLPDVLIVNAKSTFRRMIDARDFVGEAVWTRASARGD------HLFGSFDVSFYDAAGGR 175 Haliangium ochr...
WP_025360886  72 VRDRLMPAFTSWTLQDYWDRQLPNILITSLSSKFKRPIDPRSFSGEVGFTRITQRS-------LLIAETACRFWDDNGGQ 144 Kutzneria
WP_014173120  91 AQNRLPPVFAAWTLDDYWQRQLSDILITRFTSRFHRAIRGQEFRGELSFTDFKLRSGengrapLALIESECRFWDKGGGR 170 Streptomyces
WP_014987674  80 VRGQL-GVFAEWTMDDFWRRQLPDILITRFHSDFRRPIDPRRFSGEFTLDDSRERTSsldgtpFTALDTSFRCWDDHGGH 158 Nocardia brasil...
P9WM67        94 VLNEEIRVLRGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERtw---rYLKVPCVIEFWDENGGA 170 Mycobacterium t...
Q9CBG3        94 VVNKDISALRGWSIADYCRNQLSGILIKNTSSRFKKLINPQKFSARLHVYDLRIVERtw---rYLQLSNTIEFWDDNGGS 170 Mycobacterium l...
WP_012823830  91 TKYELVPQFCAWGTEGFFSRQLPDILITSFNSRFTKPVNSVDFSGEFTIHTMRLHNKgq---pFLFIKTGCRFFDDEQGE 167 Halothiobacillu...
2PFC_A        94 VLNEEIRVLRGWSIDDYCQHQLSSMLIRKASSRFRKPLNPQKFSARLLCRDLQVIERtw---rYLKVPCVIEFWDENGGA 170 Mycobacterium t...
5WSX_A       176 CDGEAVLAF 184 Streptomyces avermitilis MA-4680 = NBRC 14893
WP_015209316 171 AEGDVTIAI 179 Cylindrospermum stagnale
WP_012831083 176 STGE---TF 181 Haliangium ochraceum
WP_025360886 145 ASGEITLAI 153 Kutzneria
WP_014173120 171 CTGEIQIAl 179 Streptomyces
WP_014987674 159 CAGVVRLAV 167 Nocardia brasiliensis
P9WM67       171 ASGEIELAA 179 Mycobacterium tuberculosis H37Rv
Q9CBG3       171 AIGEFEVAI 179 Mycobacterium leprae
WP_012823830 168 AVGEVDLAI 176 Halothiobacillus neapolitanus
2PFC_A       171 ASGEIELAA 179 Mycobacterium tuberculosis
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap