Conserved Protein Domain Family
SecM_small

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pfam10818: SecM_small 
secA translation cis-regulator SecM, small type
In E. coli, SecM encodes a presecretory protein that regulates secA expression at the translational level. SecM contains a C-terminal sequence motif that induces a transient translation arrest. SecM signal peptide plays an essential role in this regulatory process by acting as a molecular timer that coordinates secM membrane targeting with the synthesis of the arrest motif.
Statistics
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PSSM-Id: 491442
Aligned: 6 rows
Threshold Bit Score: 90.6444
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q7VKT2        13 WSQLVFGVMAILALPEFQTTVASEs---ENEQNTI----------INQAVMQSALSVd-EVEQQALFVelkq-iihnIAP 77  [Haemophilus] d...
WP_010785753  13 ISQFLLGIVAIFALPTAQPLANES----ETLPTNQlvlrlsdfssVQKVELEAAHLL--HLEQQPLVI---------PTK 77  Glaesserella pa...
P44073        11 WSRLLLSIIAIFALPNAQSFENQNn--tENYSSSV----------SIQQALETVKVAr-EVQRQAipqps---isrqTEK 74  Haemophilus inf...
Q9CLK6        12 WSRLLLSMIAIFALPQSQELSTPTglphENHRSSQl---------IQQQISHTIAIAq-HVQQQSYHLivp----pqNKP 77  Pasteurella mul...
WP_012073744  11 WSQLLFSMIAMFALPQVQQWQHAEan-nPTYQNQS----------VQRQIACVAQNLqqKQAQQQFWAvsp----ieSQK 75  Actinobacillus ...
WP_015432920  13 WTQFFFGIVAVLALPEVSHS--------ESHNTDNv---------AEQQVLNVVPTIk-QADSEQIFLqqartsvqqPIK 74  Bibersteinia tr...
Q7VKT2        78 QAVVFYDFLTKCYRFEVdyqPPIRAGPfI 106 [Haemophilus] ducreyi
WP_010785753  78 QAVVFCEFFAKSYRLYQvsnPPIRAGP-T 105 Glaesserella parasuis
P44073        75 QLKIQPHFFTEALNIS----APIRAGP-L 98  Haemophilus influenzae Rd KW20
Q9CLK6        78 YVRQNQAFFASILTYSL---PPIRAGP-I 102 Pasteurella multocida
WP_012073744  76 LLEFRPHFSGAVFTFH----APIRGSP-R 99  Actinobacillus succinogenes
WP_015432920  75 QAVEICIFSAKYYRLEChpnPPIRAGP-V 102 Bibersteinia trehalosi
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