Conserved Protein Domain Family
DehI

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pfam10778: DehI 
Halocarboxylic acid dehydrogenase DehI
Haloacid dehalogenases catalyze the removal of halides from organic haloacids. DehI can process both L- and D-substrates. A crucial aspartate residue is predicted to activate a water molecule for nucleophilic attack of the substrate chiral centre resulting in an inversion of the configuration of either L- or D-substrates in contrast to D-only enzymes.
Statistics
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PSSM-Id: 402418
View PSSM: pfam10778
Aligned: 6 rows
Threshold Bit Score: 164.995
Threshold Setting Gi: 284017231
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Npun_F0199   397 PWTPANWR-AYAMYPSVMQLFWQRLKPAMQTEAFLEDAIAISEHVYRDINDWYQPGYQI-------EVEQAQQHHIRQEL 468 Nostoc punc...
WP_011521593      30 PYVPTIFK-AAAGNSTYIREMWDDLYEVACSKEFHASAETLNQFINAQVIGTRWRFSNQerlltaqKFSPADVRVMAGVA 108 Candidatus ...
jgi:Acid345_2343  35 GYVPVPFQ-AFAAYPAFLDALIKAMRPLLATREFFDSAARLRAEAYTDVHNYFKVAAIG-------EGLSAAEAAAEMEL 106 Candidatus ...
WP_022543990      80 PIINFIFR-ALAQYEKFLYTGWQQVRSSMLTMSAERAAASLREPSLSFVPERYDWASIM---------GMERLKKVEKIV 149 Bacillus sp...
WP_015408529      30 PIVNWIFRtTMANHPEFVRCMWGQLKPAFETRQFGRVSVAYRDSVLSPLERERDLPAYRra---dvGVSPAEYAELRAQL 106 Natronomona...
jgi:Htur_4368     30 PIVNWIFRtTTANYPEFLRYAWGQVKPAFETARFGRFSVSYRDTILSALEAETSIPTYRrd---elEVTPAEYGELRGQL 106 Haloterrige...
jgi:Npun_F0199   469 NAFIFGNPQLL--IQQIALSKTLAGEIVGQ-DGSIDSRHGPnayrhhQIQLIDEQSAQEISPEMPQVYQDIKQTLGVPIV 545 Nostoc punc...
WP_011521593     109 STFQRALPRMA--LFTRLMQRGYSGGQRGRvSARHGSSPFA------RMITLHIPSESEASLRTWLIYSEIKRNTASKQV 180 Candidatus ...
jgi:Acid345_2343 107 FGFVESAMLLMlsVQSQAFEGPVGLDVAGHpAGLMAIMSSP-----------DFVNSETTSPPVKRVLDEQRHLLELAYY 175 Candidatus ...
WP_022543990     150 FTFNYVNPKLL--LIALAWQESLGYRPIKGvALSGGLIEPGillglpSIRLIDFPEADSRQKELLWDIMTVKHSYD---I 224 Bacillus sp...
WP_015408529     107 STFDVVAPRLA--VLFEVVERSLSGEPVGT----------------------TPERSRAATEPLPPELDRDRGGPPTLAT 162 Natronomona...
jgi:Htur_4368    107 ATYDIVAPRLA--VLFELVDRALTDEPIGT----------------------DPDRSRAATAPLPDWLDADRGRPPTMVA 162 Haloterrige...
jgi:Npun_F0199   546 NSDY 549 Nostoc punctiforme PCC 73102
WP_011521593     181 PSMF 184 Candidatus Koribacter versatilis
jgi:Acid345_2343 176 SDEQ 179 Candidatus Koribacter versatilis Ellin345
WP_022543990     225 ASDY 228 Bacillus sp. NRRL B-14911
WP_015408529     163 VEDP 166 Natronomonas moolapensis
jgi:Htur_4368    163 FDEP 166 Haloterrigena turkmenica DSM 5511
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