2L02,2L01


Conserved Protein Domain Family
DUF2582

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pfam10771: DUF2582 
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Winged helix-turn-helix domain (DUF2582)
This family is conserved in bacteria and archaea. The function is not known. The structure of two proteins in this family were solved using NMR and shown to adopt a winged helix-turn-helix fold. Structural analysis shows that these proteins form an unusual dimeric conformation. This dimer was shown to be similar to that found in the FadR and TubR wHTH domains. It was suggested that these proteins are not very likely to bind to DNA.
Statistics
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PSSM-Id: 402413
View PSSM: pfam10771
Aligned: 18 rows
Threshold Bit Score: 71.1375
Threshold Setting Gi: 14286063
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2L02_B         1 MDKKI---VGANAGKVWHALNEa--DGISIPELA---RKVNL-SVESTALAVGWLARENKVVIE-----RKNGLIEIYN 65  Bacteroides thet...
Q8ABX5         1 MDKHI---IGENAGKLWRLLSTdvhRKWTLQEVK---DATGF-NDLEAASAIGWLAREDKIQFElehhsTKDKNVFLYL 72  Bacteroides thet...
Q602J4         1 MHDDIattVGNAAGKIWHFLDQn--GEASASRLA---DETGL-DRNEVQRAIGWLAREGKLVTE-----RRGRYEFFRL 68  Methylococcus ca...
jgi:Maeo_0009  1 MDNIVn-kIGEIAGEIYHILKE---GEKNMSGLKkplKEKGY-TDSLITMAIGWLARENKIDIY-----KQERQTIVKL 69  Methanococcus ae...
Q59003         1 MEDMWg-kIGETAGKIYHLLEG---GEKSLSQIEkilRKEGY-NSNIVKMAIGWLAREDKIFVL-----KDDKKWVIKL 69  Methanocaldococc...
2L01_A         3 MLKEK---AGALAGQIWEALNGt--EGLTQKQIK---KATKLkADKDFFLGLGWLLREDKVVTS-----EVEGEIFVKL 68  Bacteroides vulg...
Q8A6Q7         1 MDRKQ---IGVYAGKVWQLLSNn--EKWGYGTLK---RKSGL-KDKELGAALGWLSKENKIEFD-----QCDEELYVYL 65  Bacteroides thet...
WP_005826242   1 MNKSE---IGLNAGKVWQLLSDy--TRWSYGSLK---RKSGL-KDKELGAALGWLAREDKIEIH-----QEEDELYVSL 65  Bacteroides
Q5LAG2         1 MDKNE---IGLNAGKVWQLLSNn--DKWSYGNLK---KKSGL-KDKDLGAALGWLAREDKIEFE-----QEEEELYVYL 65  Bacteroides frag...
WP_005841264   1 MDKHQ---IGVNAGKVWKLLNDn--KRWSYCDLK---RASEL-SDRDLNAAIGWLARENKIDFE-----CSNGDDCLFL 65  Bacteroides
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