2L02,2L01


Conserved Protein Domain Family
DUF2582
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pfam10771: DUF2582 (This model is not part of the current CDD release)
Winged helix-turn-helix domain (DUF2582)
This family is conserved in bacteria and archaea. The function is not known. The structure of two proteins in this family were solved using NMR and shown to adopt a winged helix-turn-helix fold. Structural analysis shows that these proteins form an unusual dimeric conformation. This dimer was shown to be similar to that found in the FadR and TubR wHTH domains. It was suggested that these proteins are not very likely to bind to DNA.
Links
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Statistics
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PSSM-Id: 519528
Aligned: 16 rows
Threshold Bit Score: 71.9442
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2L02_A        1 MDKKI---VGANAGKVWHALNEa--DGISIPELA---RKVNLS-VESTALAVGWLARENKVVIE-----RKNGLIEIYN 65  Bacteroides theta...
Q8ABX5        1 MDKHI---IGENAGKLWRLLSTdvhRKWTLQEVK---DATGFN-DLEAASAIGWLAREDKIQFElehhsTKDKNVFLYL 72  Bacteroides theta...
Q602J4        1 MHDDIattVGNAAGKIWHFLDQn--GEASASRLA---DETGLD-RNEVQRAIGWLAREGKLVTE-----RRGRYEFFRL 68  Methylococcus cap...
Q59003        1 MEDMWg-kIGETAGKIYHLLEG---GEKSLSQIEkilRKEGYN-SNIVKMAIGWLAREDKIFVL-----KDDKKWVIKL 69  Methanocaldococcu...
Q8A6Q7        1 MDRKQ---IGVYAGKVWQLLSNn--EKWGYGTLK---RKSGLK-DKELGAALGWLSKENKIEFD-----QCDEELYVYL 65  Bacteroides theta...
4_pfamImport  1 MTKGS---IGLNAGAIWNLLSDg--QHWSFEALR---AKSALT-DADLWSAIGWLARENKIEID-----NTSSHPIFCP 65 
1_pfamImport  1 MDKHQ---IGVNAGKVWKLLNDn--KRWSYCDLK---RASELS-DRDLNAAIGWLARENKIDFE-----CSNGDDCLFL 65 
Q8TM49        1 MTEYMnfkIGEAAGALYHRLEE---GECSLNQIKnylSSNGFD-SQMALMAIGWLAREDKIVLN-----RGSNRWSVRL 70  Methanosarcina ac...
2L01_A        3 MLKEK---AGALAGQIWEALNGt--EGLTQKQIK---KATKLKaDKDFFLGLGWLLREDKVVTS-----EVEGEIFVKL 68  Phocaeicola vulga...
WP_005789734  1 MDKNE---IGLNAGKVWQLLSNn--DKWSYGNLK---KKSGLK-DKDLGAALGWLAREDKIEFE-----QEEEELYVYL 65  Bacteroides
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