Conserved Protein Domain Family
BPA
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pfam10759: BPA (This model is not part of the current CDD release)
Bacterial proteasome activator
This is a family of bacterial proteasome cofactors. The family member from Mycobacterium tuberculosis, protein Rv3780, was shown to form rings and cap proteasome core particles. It enhanced peptide and protein degradation by proteasomes in an adenosine triphosphate (ATP)-independent manner, promoting degradation of the heat shock protein repressor HspR.
Links
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Statistics
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PSSM-Id: 519524
Aligned: 22 rows
Threshold Bit Score: 206.099
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
WP_012876953        41 EAAAD-DEAAQDDEDVSRIEEPAKVMRIGGMIKRLLDEVRDAPLDDAARSRLAEIHERSLHELEDGLSPDLVEELHRITL 119 Xylanimon...
WP_012243849        27 ENSTT-TAARPRTAIQDLVDEPAKVMRIRTMVRELLEEVKSAPLDEAARSRLAEIHERSIKELEDGLSPDLVQELHRINL 105 Renibacte...
jgi:Celgi_0185      42 PGGTD-EPEDADEDVRGMVAQPAKVMRIGTMIKQLLDEVRSAPLDDAARARLAEVHERSLHELEEGLSPELIEELHRITL 120
jgi:Cfla_3178       37 TDAPD-GARGGDENVAAMVGQPAKVMRIGTMIKQLLDEVRSAPLDDAARARLAEIHERSLHELEEGLSPELLAELHRITL 115
WP_012725428        25 aiGADtPEEKGPTDPTSLVEEPAKVMRIGTMLKQLLEEVKAAPLDDAARERLAEVHERSLHELEDGLSPELIAELHRITL 104 Beutenber...
WP_013839916        40 TEAPA-EGEADEDDETSRIEEPAKVMRIGGMIKRLLDEVRDAPLDEAARTRLAEIHERSIHELEDGLSPDLVEELHRITL 118 Isopteric...
zhongguo:AS9A_0151  22 AAQNG-KPESSSTALTDLVEQPAKVMRIGTMIKQLLEEVRAAPLDEASRTRLREIHESSIQELQDGLAPELRDELTRITL 100
1_pfamImport         2 TAAEG-ERPGSEESLADMVEQPAKVMRIGTMIKQLLEEVRAAPLDDASRSRLKEIHKTSVHELEQGLSPELRDELERLAL 80 
WP_011753675        33 ePGES-GDEDDERAITDLVEQPAKVMRIGSMIRQLLEEVKAAPLDEASRNRLKEIHQASIKELEAGLAPELVEELDRLTL 111 unclassif...
WP_083796025        31 ARGDD-ESGENPMNVAEMVEQPAKVMRIGSMIKQLLEEVRAAPLDEASRARLREIHRSSIAELEKGLAPELVAELERLSL 109 Catenulis...

WP_012876953       120 PFADDGApPSDAELRIAQAQLVGWLEGLFHGIQTALVAQQMA--AQAQLSQMRRg-LPPGgfpg--gpgpGGLGGAGMHH 194 Xylanimon...
WP_012243849       106 PFKEDVT-PSDSELRISQAQLVGWIEGLFHGIQTALAAQQMAnqQTAAQLQLRQ--LPPGtvi-----apGVIIGENGEP 177 Renibacte...
jgi:Celgi_0185     121 PFTEDAT-PSDAELRIAQAQLVGWLEGLFHGIQTALVAQQMA--TQAQLHQMRRa-LPPGavr-----ppGMAASDEGAD 191
jgi:Cfla_3178      116 PFTEDQA-PSDAELRIAQAQLVGWLEGLFHGIQTALVAQQMA--AQAQLTQMRRa-LPPGhvp-----gpGGLTVPHADE 186
WP_012725428       105 PFTDAST-PSDAELRVAQAQLVGWLEGLFHGIQTALVAQQMQ--AQSQLTQMRRa-LPPGvmpvpghgagGQVPVARADD 180 Beutenber...
WP_013839916       119 PFSDDGA-PSDAELRVAQAQLVGWLEGLFHGIQTALVAQQMA--AQAQLSQMRRq-LPPGahpa--lfgpGGPGQHRPED 192 Isopteric...
zhongguo:AS9A_0151 101 PFGEDAV-PSDSELRIAQAQLVGWLEGVFHGIQTALFAQQMA--ARAQLEQMRQgaLPPGms-------lGHAHHDPEHP 170
1_pfamImport        81 PFGEDSI-PSDAELRIAQAQLVGWLEGLFHGIQTALFAQQMA--ARAQLEQMRHa-LPPG-----------------AQV 139
WP_011753675       112 PFTEDTV-PSDGELRIAQAQLVGWLEGLFHGIQTAIYAQQMA--ARAQFEQIRKa-LPQA------------MNPGAGQP 175 unclassif...
WP_083796025       110 PFAEDEV-PSESELRIAQAQLVGWLEGLFHGIQTALFAQQMA--ARAQLEQIRRa-LPPG-----------SVPPGMADG 174 Catenulis...

WP_012876953       195 GEHGEDgrp--spGQYL 209 Xylanimonas cellulosilytica
WP_012243849       178 QRAPVT-------QRPA 187 Renibacterium salmoninarum
jgi:Celgi_0185     192 Gpg--------gtGQYL 200
jgi:Cfla_3178      187 G----PddlrpstGQYL 199
WP_012725428       181 Gdr--------apGQYL 189 Beutenbergia cavernae
WP_013839916       193 Grp--------spGQYL 201 Isoptericola variabilis
zhongguo:AS9A_0151 171 EHGGHSat---gtGQYL 184
1_pfamImport       140 PRDGGQggsitggGQYL 156
WP_011753675       176 RPDGEAprpgdsgGMYL 192 unclassified Nocardioides
WP_083796025       175 EQPGRIsg----aGPYL 187 Catenulispora acidiphila
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