Conserved Protein Domain Family
Med1

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pfam10744: Med1 
Mediator of RNA polymerase II transcription subunit 1
Mediator complexes are basic necessities for linking transcriptional regulators to RNA polymerase II. This domain, Med1, is conserved from plants to fungi to humans and forms part of the Med9 submodule of the Srb/Med complex. it is one of three subunits essential for viability of the whole organism via its role in environmentally-directed cell-fate decisions. Med1 is part of the tail region of the Mediator complex.
Statistics
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PSSM-Id: 402396
View PSSM: pfam10744
Aligned: 65 rows
Threshold Bit Score: 136.727
Threshold Setting Gi: 387515005
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCH62440              11 KKMIEKFQE--YkPGS-VTLDNITKLCQTLGLESFiddigNGVSRLSTASKIIVIDIDFdkIEGKVKDVKLVLASNfdnf 87   Tetrap...
XP_006638322          91 LTCLETLQRalKvSSLpAMTDRLESIARQNGLG-Shl--sPSGTECYITSDMFYVEVQLd-SGGQLVDVKVAHHGEnpas 166  spotte...
XP_022365352          59 VSCLETLQKalKvTSLpAMTDRLESIARQNGLG-Shl--sASGTECYITSDMFYVEVQLd-PAGQLCDVKVAHHGEnpvs 134  Enhydr...
XP_002940846          68 LRCKNMLQEalKaKSLsVILSRIECISKQKGLdsh---lgPNEKICYITSEMFYIEVQVk-KNGNVSSVKLAHHGEtpvv 143  tropic...
XP_015210061          57 LDCLERLHKalNaTSFtDMVTRLEIIAKHKGLgsh---lsPSEDVCYITSDIFYLEVLFq-PAGEVADVKVAHHGEapvs 132  spotte...
4_pfamImport           1 VRSLERLQDvfNvSSMkTMRSRLEMIAKQQGMG-Fhl--tEA--TCYLTADLFYLEVVLl-PYGGVAEVKVAPHGKapvp 74  
NP_001018472          54 AKCLQKINEalNvSSSaAMVSRLEMIAKQRGLgsh---lsPTETVCYLTADLFYIEVLLl-PGGRVEDVRVAHHGEapvs 129  zebrafish
WGS:AAPU:GI11550-PB   81 QSALDKLQHyiKvTSRhGLVERLESLSRQLGLKFM-----EDQQTLFISTDMFYVEILLd-ASGNLSDVKVHHECKieqq 154  Drosop...
Q2M094                63 QSALDKLQHyiKvTSRhGLVERLESLSRQLGLKFM-----EDQQLLFISTDMFYVEILLd-ASGNLSDVKVHHECKieqq 136  Drosop...
XP_014114165          41 LSCMEKIERtlNaKSMfSVMNALELLSRQKGLT-Vhv--sPSGTACYITSMMFYVEIQLe-KDGDVMDVKLAHFEEapvv 116  Tibeta...
CCH62440              88 nyyntniehkamdsttnnnsandndddKSKNILFNSLSeYSTLHEFHHNLQYLYLLDSFSQIevDPLNSSSVGTGSNTAG 167  Tetrap...
XP_006638322         167 -----------------------------cpeLVQHLR-ERNFEEFSKHLKGLVNLYKLPGDnkLKTKMYLALQSLEMDL 216  spotte...
XP_022365352         135 -----------------------------cpeLVQQLR-EKNFDEFSKHLKGLVNLYNLPGDnkLKTKMYLALQSLEQDL 184  Enhydr...
XP_002940846         144 -----------------------------cneLLQFLR-AKDFKAFGRSLEGLLLLYNIPGNseIKAKVYIALRSLEADL 193  tropic...
XP_015210061         133 -----------------------------semLCNLLR-LKNFEEFGKELEGLSSLFNTSGDseTNMKMFSALQFVEKDL 182  spotte...
4_pfamImport          75 -----------------------------sesFLQLLR-SKEFAEFSVKLAGLFTQYDIPGDseTRLKLFSSMQWLWKDL 124 
NP_001018472         130 -----------------------------spsLLQLLR-MKQFEEFSLKLDDLASFYNIPGDsdVKIKVYSSLRHLETDL 179  zebrafish
WGS:AAPU:GI11550-PB  155 -----------------------ssssASSTELLNCLR-AGDFADFTVQLEGLSSIYQLNAEpkVKKKAFVALQAMETDI 210  Drosop...
Q2M094               137 -----------------------------sseLVKCLK-SGDFADFTVQLEGLSSIYQLNAEpkVKKKAFVALQAMETDI 186  Drosop...
XP_014114165         117 -----------------------------cddLVQLLR-MKNYDAFGKILEDLSNMYQIPGNseMKAKGYLALQALEKDL 166  Tibeta...
CCH62440             168 TSTnntngnsngHnHNnhvnnhnsnnssnntnndgissvgNmSSGGTSMIS--SQGKLD----------L-FKYYTELSQ 234  Tetrap...
XP_006638322         217 TKMmhmf----rlaTN------------------------------ANTVEtiLHGSVGlvtarsgghlVtLQCYVSPYD 262  spotte...
XP_022365352         185 SKMavmy----wkaTN------------------------------AGPLDkiLHGSVGyltprsgghlMnLKYYASPSD 230  Enhydr...
XP_002940846         194 SAMfnlys----------------------------------skkpNDKEFaiLHGQVGylsprcggtpMgIEYYISPCV 239  tropic...
XP_015210061         183 LKMfqiprpvssG---------------------------------DPWLDnvLHGRIGnvtprnngypMsIEYYISPYD 229  spotte...
4_pfamImport         125 QQIsqlpsvpkdS---------------------------------DPRVDvmNHGRSGcliaekedfpMtIQFYAPPTD 171 
NP_001018472         180 FKIshlprslreS---------------------------------DLHIDliMNGRIGnvqsgregspMtIEYYISPAD 226  zebrafish
WGS:AAPU:GI11550-PB  211 FSLyqhq--lqlQ-QQ------------------------LsSSTDSYHIM--NNSSVGlvlqrrgghpVkLTYFCPPLH 261  Drosop...
Q2M094               187 YSLyshq--mqnRtGD------------------------------SYDIM--NSSAVGlvlqrrgghpMkLTYFCPPIH 232  Drosop...
XP_014114165         167 YSMslld-----------------------------------rtqdLNRVTevLNGKVGhlvprtggtpMnIEFYISPYQ 211  Tibeta...
CCH62440             235 FIDEYFvaNNAPfsia--------------tnlNNMFGIYISISGE----------SKPLARIyleksrdpqqyfyeytf 290  Tetrap...
XP_006638322         263 VFEEetgallnlt-----------dsnvprnlgVGVSVTIEGTSSVyklpiaplitGTHPVdnkgtp----------sfs 321  spotte...
XP_022365352         231 LLDDkttspiilh-----------ennvprslgMNASVTIEGTSAMyklpiaplimGSHPVdnkwtp----------sfs 289  Enhydr...
XP_002940846         240 LLEEKLkpGSLVg-------------------gYKAYLSIMGSNNWfllpnsplfsGLQQDsnmps------------fs 288  tropic...
XP_015210061         230 LLEEKMkpESRSc-------------------gNKVFVTAEVTNTIqrlpsasviaDSPQMTNegfpv----------ha 280  spotte...
4_pfamImport         172 GMKTsdrqeta----------------ateppvQAARVTVGVSDAAhrlqmasllpQPPQLdpqghp----------vfl 225 
NP_001018472         227 ALMGLSstGEVSa-------------------gRVALVTAGSTDSShrlqmeslisSPPQVdscgfp----------vfq 277  zebrafish
WGS:AAPU:GI11550-PB  262 LIEKKVkgEKVAtssgtasrdlsieqvikspngLSVTLNLEASSANkl-------qILPIVSI----------------- 317  Drosop...
Q2M094               233 LAEGESklASSEfsidqv---------mhsshgLSATVNLEGSSANkl-------qIMPILSF----------------- 279  Drosop...
XP_014114165         212 VLEAELnhGSQVc-------------------gTKTVVTIEGMDTLhklplsplivDPQAGEDsslvf-----------l 261  Tibeta...
CCH62440             291 sqsSNYWINEhsdsytmgislvleiIDDSSCIfpldliprdliielgdnlsnshntsntnshsnntnsnyiQTSSstTNS 370  Tetrap...
XP_006638322         322 svtNSNCVDL---------------------------------------------------------------------- 331  spotte...
XP_022365352         290 sitSANSVDL---------------------------------------------------------------------- 299  Enhydr...
XP_002940846         289 vltEECSMDL---------------------------------------------------------------------- 298  tropic...
XP_015210061         281 tldDLVSMEL---------------------------------------------------------------------- 290  spotte...
4_pfamImport         226 ssaEAPHETL---------------------------------------------------------------------- 235 
NP_001018472         278 pltEACSLLL---------------------------------------------------------------------- 287  zebrafish
WGS:AAPU:GI11550-PB  318 ---TNEAGLP---------------LEQPVYA---------------------------------------PLTQ--NNS 338  Drosop...
Q2M094               280 ---SRDPQTG---------------LELPTYA---------------------------------------QLNQ--NNS 300  Drosop...
XP_014114165         262 qltDELSMDL---------------------------------------------------------------------- 271  Tibeta...
CCH62440             371 SSSSSGFSRSSSNQIE-SNSLFTKMNSMTN-LNQHAHKLsnsnsnsnsncpTVTSSnsntnqnqssknnsnninsynkNA 448  Tetrap...
XP_006638322         332 ---PACFFLKLRRPLPfSLSFIHRMGNAT-------GIPlfet-----appLAPLYeli--------------------- 375  spotte...
XP_022365352         300 ---PACFFLKFPQPIPvSRAFVQKLQNCT-------GIPlfet-----qptYVPLYeli--------------------- 343  Enhydr...
XP_002940846         299 ---PACFCFMFTDPLPlLLPFVQKIQCIT-------GLPvag-------ikQAPFHelithl------------------ 343  tropic...
XP_015210061         291 ---SACLFLKFPRPVPiLSCFIEEFHRLTG-ISVSEDLK------------QVPFYell--------------------- 333  spotte...
4_pfamImport         236 ---PACFLLKLQPAVPmTLSFVDKLRHIT-------DIPipdv-----dlqWAPLPkll--------------------- 279 
NP_001018472         288 ---PATFLLKLQPPLPvLTSFIEKMGKITDgVIAEKPLQ------------VEPLHkll--------------------- 331  zebrafish
WGS:AAPU:GI11550-PB  339 MLMPATYVLRLSKPMPvCIESLRALG-LPG-LTSNANEE------------TPTVMnli-----------------vqTA 387  Drosop...
Q2M094               301 MLMPATYVLRLNKPMPvCYETLKSLG-LPG-VEGMAAAPsp---------pVATVLnli-----------------vqTA 352  Drosop...
XP_014114165         272 ---PALFVLKFHQPVPmSSSSIEEIQRLT-------GIQisg-------lkLAPLYeli--------------------- 313  Tibeta...
CCH62440             449 NTQALsvldngsirsvinIPsYSRKSKFQIMNDFTT------------------Km-iNIKKFDISN-DNLSLILEFLRW 508  Tetrap...
XP_006638322         376 tqSQLqeeg------ggaLPpLAHNMRFYAS--LPGqqhcyflnrdapvqdgrcLqgaLVTKVPFRHpAQVPALLDIIRH 447  spotte...
XP_022365352         344 tqFELskd--------pdPIpLNHNMRFYAA--LPGqqhcyflnkdaplpdgrsLqgtLVSKITFQHpGRVPLILNLIRH 413  Enhydr...
XP_002940846         344 ------------enscctTDeASTDAQFILS--IPDcrdhcyait-svtdnkeaLmgiLVDKIPFTHpSQVPPTLEVLRH 408  tropic...
XP_015210061         334 mkTKMnvt-----------twgSDSCCFLVT--LPGhhrqgyvi--sqqwwlkpWegaLVHKIPFTHpGHVPSLLSLLRH 398  spotte...
4_pfamImport         280 tgRSNgp----------gELpDEQDTIFTVP--LPDgalhryvllaaawgeapaQraaAVDSIPFTHpAHVPALLQLLRH 347 
NP_001018472         332 lkTSRkynp---------ntscTDGLQFLVP--LPGsechsyvfp-gaqwscenWngaLMDAVPFSHpGHVPALLEILRH 399  zebrafish
WGS:AAPU:GI11550-PB  388 SRQLIrntq------kglYVnLPKETHCYFFTDNHR------------------LkgtMISSLPFTEpAQVPKIIAFLKK 443  Drosop...
Q2M094               353 SKQAIkntq------rglYVnLPKETHCYFFTDNRK------------------LqgtLISSLPFTEpAQVPKIMTFLKK 408  Drosop...
XP_014114165         314 vqSTLkekcs--------edlsTNKSCFFVS--LPDcpkhcyfi--nkgseksdLagaLVSKIPFSHpKCVPGVIEILRH 381  Tibeta...
CCH62440             509 VRWSKIILNPVI 520  Tetrapisispora blattae CBS 6284
XP_006638322         448 QAAYNTLIGSCV 459  spotted gar
XP_022365352         414 QVAYNTLIGSCV 425  Enhydra lutris kenyoni
XP_002940846         409 QAAYSTLINSCI 420  tropical clawed frog
XP_015210061         399 QTAFSTLIASCV 410  spotted gar
4_pfamImport         348 QSAINTLLRSCI 359 
NP_001018472         400 QSAISVLLESCF 411  zebrafish
WGS:AAPU:GI11550-PB  444 QALFYTLLSSCI 455  Drosophila mojavensis
Q2M094               409 QALFYTLLASCV 420  Drosophila pseudoobscura
XP_014114165         382 QVAYNTLISSCV 393  Tibetan ground-tit
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