6XP5


Conserved Protein Domain Family
Med1

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pfam10744: Med1 (This model is not part of the current CDD release)
Mediator of RNA polymerase II transcription subunit 1
Mediator complexes are basic necessities for linking transcriptional regulators to RNA polymerase II. This domain, Med1, is conserved from plants to fungi to humans and forms part of the Med9 submodule of the Srb/Med complex. it is one of three subunits essential for viability of the whole organism via its role in environmentally-directed cell-fate decisions. Med1 is part of the tail region of the Mediator complex.
Statistics
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PSSM-Id: 519519
Aligned: 53 rows
Threshold Bit Score: 166.789
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6XP5_a       118 EEVIHILS---KsKGL-VSEAGLERLARSLELEFMWE----------SSM-------GsdNKRTLIVAGSALELLVEF-S 175 Thermochaetoide...
XP_015210061  57 LDCLERLHkalNaTSFtDMVTRLEIIAKHKGLgsh--------------------lsP--SEDVCYITSDIFYLEVLFqP 114
6_pfamImport   1 VRSLERLQdvfNvSSMkTMRSRLEMIAKQQGMG-Fhl-------------------tE--A--TCYLTADLFYLEVVLlP 56 
1_pfamImport   1 VCLCVLSSflsIvASVnAMMTRLEMIAKQKGLG-Shr-------------------sP--TETACYLTADLFYLEVLLlP 58 
NP_001018472  54 AKCLQKINealNvSSSaAMVSRLEMIAKQRGLgsh--------------------lsP--TETVCYLTADLFYIEVLLlP 111
XP_007374703   9 DTSLQLLYd--YsSNFqISVELVQKLAQHLKLETFID----------TSFqfgnvegN--NQQRLTIAASSILLDIDFeN 74 
Q5AHH0         9 DKSLQLLYn--YsTNFqVSIELIQKLAQQLKLETFIDslgfnl--------ddskpgQ--KTQKLSIAGSSILLDIDFeT 76  Candida albicans
XP_002547140  10 DKSLQLLYa--YsSNFqISVELIQRLAQQLKLETFIDnlgfqlqnstNNT----------NVQKLTIAASSILLDLDFeS 77 
EMG50608       9 EKSLQSLYd--YsSNFqVSVELIQKLAQQLKLETFIDnlgfplqepsNTTtgr--ngT--NTQKLTIAASSILLDIDFeN 82 
XP_001384277   9 ENSLSSLYd--YsSNFkVSIDLVQRLAHQLKLETFVDklgytvdaahQTpg-----gG--KTQRLTIAGTSILIDIDFvD 79 
6XP5_a       176 QDVVQSVTLNFPDSpeiv---------------------------------------------------tkhAQKAGEIL 204 Thermochaetoide...
XP_015210061 115 AGEVADVKVAHHGEapvs----------------------------------------------------------semL 136
6_pfamImport  57 YGGVAEVKVAPHGKapvp----------------------------------------------------------sesF 78 
1_pfamImport  59 GGGVQDVKVAQHGEapes----------------------------------------------------------nsaL 80 
NP_001018472 112 GGRVEDVRVAHHGEapvs----------------------------------------------------------spsL 133
XP_007374703  75 DRKVSNISLSIGNEsthttenskeyiesvqnnhgi----------------tviklnpnknpltflkkssdeKSIAEKIL 138
Q5AHH0        77 DNKIVGLSLSVNAGdsleqqnnhreigppnhttngqssshisivtdelgihhvklncnnnpisflnkpndlnKTQVEQIL 156 Candida albicans
XP_002547140  78 DTKIVNLSLSINGSenlqtgepytihkdelglth------------------vklncnnnrvtflnkssnsnKTQVEEIL 139
EMG50608      83 DSKIVNLSLSINGSeniqstegrcftitppnetnvs---------------qvklncnynnvtflnkregssKTQVEEIL 147
XP_001384277  80 DNDIVNVSLSLANHtsssssisevknpnshiksstqdan---------gvtnllidpaknpvsffqqgtsgsASIAEEIL 150
6XP5_a       205 FNDLRlapgqsplTKSLARFAANFERLAVLDKLSIL--PGLNLYEAVADVYESLARLh--------A-WElqklredpsl 273 Thermochaetoide...
XP_015210061 137 CNLLR--------LKNFEEFGKELEGLSSLFNTSGDseTNMKMFSALQFVEKDLLKMfqiprpvssG------------- 195
6_pfamImport  79 LQLLR--------SKEFAEFSVKLAGLFTQYDIPGDseTRLKLFSSMQWLWKDLQQIsqlpsvpkdS------------- 137
1_pfamImport  81 CQLLR--------MKKFKEFSVKLDDLASLYNIPGDsdTKIKVYASLQHLQKDLLKIsnlp------------------- 133
NP_001018472 134 LQLLR--------MKQFEEFSLKLDDLASFYNIPGDsdVKIKVYSSLRHLETDLFKIshlprslreS------------- 192
XP_007374703 139 LANLS--------QPKLNKFPENLQYLAIIDKYAN---SNQDLFTYIERTALLLHTIsqleiernpNnWQ---------- 197
Q5AHH0       157 LRNLQ--------ASKLGNFPVNLQRLATIDKFTN---YNPDLFIYVESIALLFNTIfeieqqsnsSnWE---------- 215 Candida albicans
XP_002547140 140 LSNLQ--------GPKLGNFPANLQYLAIIDKFAN---HNPELFIYIETISFLLNTInqid--kelEdWQ---------- 196
EMG50608     148 LRNLH--------GVKLGNFPLNLQYLATIDKYAN---FNPDLFIYIESIALLLTTInqie-gkvsDnWE---------- 205
XP_001384277 151 LSNLR--------SKKLNSFPVNLKYLAGMDKLSS---SSVDVFSFLERVALLLYTIssvqstndpRdWL---------- 209
6XP5_a       274 agkddeyLENLVLCTKSGKPAMN--DRGRVG----------LaLDYWKEK-HLLRtpeaeva------------------ 322 Thermochaetoide...
XP_015210061 196 ------------------DPWLDnvLHGRIGnvtprnngypMsIEYYISPyDLLEekmkpe------------------- 238
6_pfamImport 138 ------------------DPRVDvmNHGRSGcliaekedfpMtIQFYAPPtDGMKtsdrqet------------------ 181
1_pfamImport 134 ----rrlIESDVH------VDMV--LNGRIGnfvpcregnpMsIQYYIRPsDVLMemfcp-------------------- 181
NP_001018472 193 ------------------DLHIDliMNGRIGnvqsgregspMtIEYYISPaDALMglsstg------------------- 235
XP_007374703 198 --------IEQGLNNAIGNVKIHdiTQGKIG----------LfLEFWKDFrYINHesntaigntynvqfn--------iv 251
Q5AHH0       216 --------IENGLSSSIGKVNIN--NEDRLG----------VtLDFWQDYrFINHeyeivknqsgllvgdyyti-qvdiv 274 Candida albicans
XP_002547140 197 --------PEFGI---LGNVKLN--QDKKLG----------VvLDFWKDYrFINReyrsikgtdellvgqnyel-klnvv 252
EMG50608     206 --------IEQGFKSSVGAVKLN--INDKLG----------VrLDFWKDYrYINHeysimkstdellvgqeyniqlkvvd 265
XP_001384277 210 --------LSEGYITSTGKIRINddNKQQLG----------VfSDYWQDNrYINHengdktnlvgknynmllk---ivss 268
6XP5_a       323 -------swiadnERTWSILIGCAPLrd-------lSINPVRI----------SDKWIGPnvvktslpdglhtgePIIDW 378 Thermochaetoide...
XP_015210061 239 --------srscgNKVFVTAEVTNTIqrlpsasviaDSPQMTNegfpvhatldDLVSMEL-------------------- 290
6_pfamImport 182 ------aateppvQAARVTVGVSDAAhrlqmasllpQPPQLdpqghpvflssaEAPHETL-------------------- 235
1_pfamImport 182 --------gegsrGQVAMVVVGASS-----------TTHMLQM----------ESHILTP---------------PQFDS 217
NP_001018472 236 --------evsagRVALVTAGSTDSShrlqmeslisSPPQVdscgfpvfqpltEACSLLL-------------------- 287
XP_007374703 252 sssynheyllennKKEWEIANQGNKErvkfe-fedaVIPTVNNdgt----nttMLPWM---------------------- 304
Q5AHH0       275 easkqtdylldnqVQEWDISMSkykfe-----fdsnSLKPLVLdg------dgFLAWS---------------------- 321 Candida albicans
XP_002547140 253 dstnqvdylidnqIQEWEIAHGkykf------efenTLKPLVVdg------dnFSAWA---------------------- 298
EMG50608     266 stsdqidylidnqVQEWNLINGkyrf------efenTLKPLIVeg------enFSAWA---------------------- 311
XP_001384277 269 hreskldyfeenrTKVWDLHSPQGGYkpyrfdfdvtSNPDFLP---------------GN-------------------- 313
6XP5_a       379 LDPEPTFipatdqqqqqqqqqqqqqqqqqqqqqaDAPLLPPRLPEVAFHAVFDPPVHiPINLWQHLQEMGC-VlpdeTAT 457 Thermochaetoide...
XP_015210061 291 --------------------------------------------SACLFLKFPRPVPiLSCFIEEFHRLTG-I----SVS 321
6_pfamImport 236 --------------------------------------------PACFLLKLQPAVPmTLSFVDKLRHIT---------- 261
1_pfamImport 218 LGFPVFR---------------------------PMSEVKTESLPAFFLLKLQPPVPtLNSFIQQMNQITD-V----TPE 265
NP_001018472 288 --------------------------------------------PATFLLKLQPPLPvLTSFIEKMGKITDgV----IAE 319
XP_007374703 305 -----------------------------------------------FDLVLNHPIYvPKYILEYLG-----L----DYT 328
Q5AHH0       322 -----------------------------------------------LQFKLNHSVYlPVYILEYFSLALG-N----NYT 349 Candida albicans
XP_002547140 299 -----------------------------------------------LQLELNHSVYlPVFVLEYLGF----L----DYT 323
EMG50608     312 -----------------------------------------------IQLDLNHPVYlPRYILEYFGI----D----NYT 336
XP_001384277 314 --------------------------------------------NLSIELVLNHPVYlPVYLLEYLGL----L----DYK 341
6XP5_a       458 QPf-------qQHHFrsfdslviPppqgketdatetrvfscrkktpfvprrsGVRNGE------GATQKMEYRIHQNTLF 524 Thermochaetoide...
XP_015210061 322 EDl-------kQVPF--------Yell------------------------mkTKMNVtt-----------wgSDSCCFL 351
6_pfamImport 262 -DipipdvdlqWAPL--------Pkll------------------------tgRSNG----------PGELPDEQDTIFT 298
1_pfamImport 266 ADl-------qVEPL--------Fqli-----------------------kqLSLTEKtcesmcDEETLPDAELHSYVFG 307
NP_001018472 320 KPl-------qVEPL--------Hkll------------------------lkTSRKYnpn---------tscTDGLQFL 351
XP_007374703 329 VEentt-------------------------------------------dplfKIFDKinnsqeVVDSINI-LGRNVSCL 364
Q5AHH0       350 LDtgdh--------------------------------------------nccNVFAKinegesFEQVLNI-DSNSVSFQ 384 Candida albicans
XP_002547140 324 TSeaeq--------------------------------------------slkDVFEKvnngeeFEQVLNI-DSNNVSFQ 358
EMG50608     337 TSne-----------------------------------------------qeDVFEKlnngdeFEQTLNL-DATNVSFQ 368
XP_001384277 342 KKktgt--------------------------------------------ivdEMFETlntgdeIVNKVILESNSEISFK 377
6XP5_a       525 VPKPVMC------------------R----TLTEMSFSHpQQLVSILPYLRQYAFLAQLLENSFK 567 Thermochaetoides thermophila D...
XP_015210061 352 VT--LPGhhrqgyvi--sqqwwlkpWeg-aLVHKIPFTHpGHVPSLLSLLRHQTAFSTLIASCVT 411
6_pfamImport 299 VP--LPDgalhryvllaaawgeapaQra-aAVDSIPFTHpAHVPALLQLLRHQSAINTLLRSCIG 360
1_pfamImport 308 GAEWKCD------------------LwkgaLIHAVPFTHpAHVPALLELLRHQSVINALLASCIT 354
NP_001018472 352 VP--LPGsechsyvfp-gaqwscenWng-aLMDAVPFSHpGHVPALLEILRHQSAISVLLESCFS 412
XP_007374703 365 INHDLISnf--------------------iPLKSVKINHlYDLSSLIPILRNFIVLSNLYRTLSQ 409
Q5AHH0       385 LTNDIPGkf--------------------vPLKSFHINKlVDISKLIPILRNFLVLINLCRTVIK 429 Candida albicans
XP_002547140 359 FSNNIPSkf--------------------vNLKSVNINQlLDIPKIIPVLRNFIVLSNLIRTVIN 403
EMG50608     369 LVNDTSS------------------Ngf-iNLKSLTINKlVEIAHIIPVLRNFLVFSNIIRTILN 414
XP_001384277 378 IAHNFTS------------------Nnv-aPIKSVVINQlTDLAILIPNFRNFLVLANIYRSLCD 423
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