Conserved Protein Domain Family
Myticin-prepro

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pfam10690: Myticin-prepro 
Myticin pre-proprotein from the mussel
Myticin is a cysteine-rich peptide produced in three isoforms, A, B and C, by Mytilus galloprovincialis, the Mediterranean mussel. Some isoforms show antibacterial activity against gram-positive bacteria, while others are additionally active against the fungus Fusarium oxysporum and a gram-negative bacterium, Escherichia coli D31. Myticin-prepro is the precursor peptide. The mature molecule, named myticin, consists of 40 residues, with four intramolecular disulfide bridges and a cysteine array in the primary structure different from that of previously characterized cysteine-rich antimicrobial peptides. The first 20 amino acids are a putative signal peptide, and the antimicrobial peptide sequence is a 36-residue C-terminal extension. Such a structure suggests that myticins are synthesized as prepro-proteins that are then processed by various proteolytic events before storage in the haemocytes as the active peptide. Myticin precursors are expressed mainly in the haemocytes. The family Mytilin has been merged into this family.
Statistics
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PSSM-Id: 151186
View PSSM: pfam10690
Aligned: 5 rows
Threshold Bit Score: 97.7212
Threshold Setting Gi: 74782634
Created: 11-May-2020
Updated: 6-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9Y0B1     1 MKAAVILAIALVAILAVHEAEA-SCASR-CKGHCRARRCGYYVSVLYRGRCYCKCLRCSSEH-----SMKF-PENEgssp 72  Mediterranean mussel
ABU80394   1 MKATILLAVVVAVFVAGTEAHPhVCTSYyCSKFCGTAGCTRYGCRNLHRGKLCFCLHCSRVKfpfgaTQDAkSMNE---- 76  Mediterranean mussel
P82103     1 MKATILLAVLVAVFVAGTEAHShACTSYwCGKFCGTASCTHYLCRVLHPGKMCACVHCSRVNnpfrvNQVAkSIND---- 76  Mediterranean mussel
CAM56837   1 MKATILLAVVVAVIVGVQEAQSvACTSYyCSKFCGSAGCSLYGCYLLHPGKICYCLHCSRAEsplalSGSArNVNDrnne 80  Mediterranean mussel
Q5XWD7     1 MKLAVILAIALAVLLIVQDADA-SCASR-CKSRCRSRRCRYYVSVRYGWFCYCKCLRCSSEH-----TMKFsPESEg--p 71  common blue mussel
Q9Y0B1    73 SDMMPQMNENENTEFGQDMptgeteqgetgI 103 Mediterranean mussel
ABU80394  77 LEYTPIMKSMENLDNGMDM-----------L 96  Mediterranean mussel
P82103    77 LDYTPIMKSMENLDNGMDM-----------L 96  Mediterranean mussel
CAM56837  81 MDNSPKMNEMENLDQEMNM-----------F 100 Mediterranean mussel
Q5XWD7    72 AEMPAQMNDHEQF---QDMqkgeteqgetgM 99  common blue mussel
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