Conserved Protein Domain Family
TcpQ
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pfam10671: TcpQ 
Toxin co-regulated pilus biosynthesis protein Q
The toxin-coregulated pilus (TCP) of Vibrio cholerae and the soluble TcpF protein that is secreted via the TCP biogenesis apparatus are essential for intestinal colonisation in the disease of cholera. TcpQ is part of an outer membrane complex of the TCP biogenesis apparatus, comprised of TcpC and TcpQ, and the TcpQ is required for proper localisation of TcpC to the outer membrane. The domain is found in other Proteobacterial species apart from Vibrio.
Links
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Statistics
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PSSM-Id: 491333
Aligned: 24 rows
Threshold Bit Score: 76.1893
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q6D9T2       348 VWKAE-PGITLREFLTRQASTVecpyggKWTVVWPVNVDYPISARLVIHGSFDA---------LLERIFFLygPGKVDTP 417 Pectobacterium ...
WP_014448789  62 TFVLV-PGESLKENFEAWGKAS------GWKVLWHSEYSFPVKARYTAGRSFLG---------AVRRSIKIf-NAGSGGW 124 Leptospirillum ...
WP_015851579 165 DWSIVpGG--LRDQLKRWAGRA------EYTLVWKANHDFEMQSHATFRDTFPR---------AVKRLFSR--MHANGNS 225 Maridesulfovibr...
Q3IFA7        97 RFE---NGSTLKKALSQYASNE------GIELYWYLSKDYVVKDHFRVDSNFTS---------TLYQVGRAi-NDDFENE 157 Pseudoalteromon...
GAC39103      98 IFK---AGSTLRSAITEYAQSE------GMQVIWELDQDFIVKHPFQLDDSLLA---------SLKIIGNAi-DANFDGE 158
WP_014102511 356 RWAAV-KGQDLRSTIESWGAQQ------GLQVIWMADSPYTVQRSVSFQGPLTG---------ALSRLLEQf-NDETERP 418 Micavibrio aeru...
WP_014103960 394 TWNAD-RGASLRDVLLQWSYDA------GVELVWNSAQDFKLPASITMKSNYTD---------AVLSVLSAf-NDQDARP 456 Micavibrio aeru...
Q5DZ53        89 vLTAQ-EGESLKNRLLDFLSNN------GYKMIWNSQYDVLFDNDIIYEGDEALd--------VVKNISDD--LSVMGID 151 Aliivibrio fisc...
Q5HXR5       222 VWTLI-EGQPIRDQMIAWGDRA------GWRVIWPEGMNWMVPVTTGFTGPFRHddghggddgVMSQVIHA--LSAQGKT 292 Gluconobacter o...
Q7WWZ0        85 AFRLV-KGEALQQQLQNWANRA------GWTVAWNVPDGWIVPGDKDYGSDFES---------AVKRVVEE--LANNGAD 146 Cupriavidus nec...

Q6D9T2       418 LYGRANRSQC--VVAVSD 433 Pectobacterium atrosepticum
WP_014448789 125 LKVHAYLSNH--VLLVED 140 Leptospirillum ferrooxidans
WP_015851579 226 LRVTLYQKNK--HIVVSE 241 Maridesulfovibrio salexigens
Q3IFA7       158 VYTYLCHKQR--AAVITE 173 Pseudoalteromonas haloplanktis TAC125
GAC39103     159 VKAYMCPLQR--SLVITS 174
WP_014102511 419 VGRIYNDPTLngQVLVVe 436 Micavibrio aeruginosavorus
WP_014103960 457 LGRLHPNLPQgpSVLVVD 474 Micavibrio aeruginosavorus
Q5DZ53       152 IHMNVYIKNN--VVLVYS 167 Aliivibrio fischeri ES114
Q5HXR5       293 ISLQLFTVNH--VALVTN 308 Gluconobacter oxydans
Q7WWZ0       147 VVGDSWRGNR--TVIISQ 162 Cupriavidus necator
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