Conserved Protein Domain Family
Misat_Tub_SegII

?
pfam10644: Misat_Tub_SegII (This model is not part of the current CDD release)
Misato Segment II tubulin-like domain
The misato protein contains three distinct, conserved domains, segments I, II and III. Segments I and III are common to Tubulins pfam00091, but segment II aligns with myosin heavy chain sequences from D. melanogaster (PIR C35815), rabbit (SP P04460), and human (PIR S12458). Segment II of misato is a major contributor to its greater length compared with the various tubulins. The most significant sequence similarities to this 54-amino acid region are from a motif found in the heavy chains of myosins from different organisms. A comparison of segment II with the vertebrate myosin heavy chains reveals that it is homologous to a myosin peptide in the hinge region linking the S2 and LMM domains. Segment II also contains heptad repeats which are characteristic of the myosin tail alpha-helical coiled-coils. This myosin-like homology may be due only to the fact that both myosin and Misato carry coiled-coils, which appear similar but are not necessarily homologous (Wood V, personal communication).
Statistics
?
PSSM-Id: 519490
Aligned: 41 rows
Threshold Bit Score: 110.04
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_001964060   5 REILSLQLGTYANYVGAHFWNQQEANFCYGDGdgddqvaeEHLlHNDILYREGLN--S-HNRTTYTPRLVSVDLAGTLAH 81 
XP_972672      4 HEILTLQFGHYSNYVGAHWWNVQEAGFRYDSP--------SEI-NHDVLFREGVT--L-KNEVTFTPRLLLVDLKGSLKT 71 
XP_002428242   4 REVVTFQFGNYSNFVGTHWWNIQESYFQYDERn------pSDI-NHDVLFREGKT--S-RGQATFTPRLILVDKAENMIN 73 
XP_001624271   7 REVITLQFGHYANFVGTHWWNIQESSFCYDAAsp-----kSEI-NHDCLFREGLT--V-TGQETYTPRLLLYDLKGSLRN 77 
Q018N1         3 SSVVTASFGTHAASVAAHFWNVRED--DSDENde----vdWNV-DHAERARVNEG----STSISYVPRWVAFDARSLRGK 71  Ostreococcus tauri
XP_003030487   2 REIVYIQSGNLANYVGSHFWNTQECYLT--DEd------eTPY-DRRMSFRESLAdsG-KGAICYSPRALIFDHKSNFGT 71 
XP_001886252   2 KEILYIQAGQLSNYTGTHFWNTQESYFTYGDGe------ePLT-NNDVSFREGIG--P-TGELTICPRLVIFDRKANFGT 71 
EED83522       2 KEVIYIQAGHFANYIGTHFWNTQESYFTYEEGe------eSEV-DHDVSFREGLS--L-KGDQTYCPRLLVFDRKVNFGT 71 
Q9P6K5         2 HEILTVTFGRKSNFCWTHFWNTQESYFVYDPNd------hAKV-NVNTNFRVLKK--RdPEAIVTVPRECIYDTPIEFGN 72  Schizosaccharom...
XP_002173475   2 HEILSFAFGGKSNFVSTHFWNAQEKYL--DQGn------dAQI-DREVAFFERKTnnI-GGDVVFHPRTLIYDDRDAFGT 71 
XP_001964060  82 LPLGGELYGnfvqrdeellpfgtgedlnktrqrveESGVAPTS--------QLELQE-EPPTQLSEYQRDLMK 145
XP_972672     72 LPQEGELYS--------------------------LPSQSAPD--------QVEIIA-QPPEEKNEFQKDIET 109
XP_002428242  74 IPILSEAPEe-------------------------STSAVSNDd-------QTIAIQdQNLPEKHEFIKDLER 114
XP_001624271  78 LSTEGLLYEg------------------------pSKKYVDWEg-------EITIYE-TNPDQKNEFQADIEK 118
Q018N1        72 TTATGLSSGda-----------------------aAAAAAAWSg-------AWTVTR-APPTRRSAYARALER 113 Ostreococcus tauri
XP_003030487  72 FAKSNILSStendq-----------------spdtAAVASLWKg-------AVDEQQ-SDPIPKSDYHAKLER 119
XP_001886252  72 LAASNALGEvddve----------------desgsESAPGPWTg-------GIVEYR-QTRMAKSVYQNRMED 120
EED83522      72 LSAASDLYGedeees---------------aaqsiLQRKIIWTahdyprggGVVEHR-QERMPKSRYQQRLDD 128
Q9P6K5        73 TRK-NWLEElne---------------------ssGGKGTAWDg-------KLTQIM-QTPVDVHPYQEALWS 115 Schizosaccharomyces po...
XP_002173475  72 TIKNSKLLQpdivennnnidifgyakndnrktgegPEDVNTWSg-------KTVCVE-APPLPLHPYQAWLDQ 136
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap