7Z2R


Conserved Protein Domain Family
Lig_chan-Glu_bd
?
pfam10613: Lig_chan-Glu_bd (This model is not part of the current CDD release)
Ligated ion channel L-glutamate- and glycine-binding site
This region, sometimes called the S1 domain, is the luminal domain just upstream of the first, M1, transmembrane region of transmembrane ion-channel proteins, and it binds L-glutamate and glycine. It is found in association with Lig_chan, pfam00060.
Links
?
Statistics
?
PSSM-Id: 519476
Aligned: 74 rows
Threshold Bit Score: 112.99
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
7Z2R_A         3 LTLKVVTVlEEPFVM-VAENILGQpKRykgFSIDVLDALAKAL-GFKYEIYQAPDGrYGHQlHN-TSWNGMIGELISKRA 79   Norway rat
XP_046441413 416 SVFKIAVVvQAPFIM--KRKANGT-VTfygYCVDLIKDIQAIM-GFEYELYEVPDGkYGNMdSKmN-WNGMIKELMEKRA 490 
XP_008200796 423 VVYRVVTVeQKPFII---KDETAP-KGykgYCIDLIQRISEIL-NFDYEITPVGDQkFGNMdEN-GKWNGVVRELMEKRA 496 
NP_001260050 421 TVYRIFTVvQAPFIMrDETAPKGyk----gYCIDLINEIAAIV-HFDYTIQEVEDGkFGNMdEN-GQWNGIVKKLMDKQA 494 
XP_002423441 378 TVYKVVTViQHPFIYyDPDSKDKD-NPysgYCIDLLEEIRKLI-KFDYVIYEAPDKkFGTMdDK-GQWNGMIKELIEKRA 454 
EFN61837     310 TNYRVVTIqHAPFMM-----YNNKtNRwygFCIDLLDAIRETV-PFEYEVREVEDGqYGALnEN-GSWDGIIRELVDKRA 382 
EFX71622      79 KRIRLTSYeDPPFVI-LERDSNGTiASyqgFIYEMIHALQQLY-NFTYEVTIPSVGtYGQEtWN-GTWDGMMGLIVNQRV 155 
EFX79318       9 RHFRIGTIhAPPYII--IEHTGRNiSHvngFVHQIVAWLAEKH-QFTFEYVGPPDGaYGAFvNG-S-WNGMVGMVIAGEI 83  
XP_011151040   7 PRYRVVTAvSSPFVM--YNSSSGSfy---gYCIDLLESMSRIS-GFDYDLVESTDQlFGHVtES-GEWTGMIADLLNDSA 79  
KAF8356358   358 TIYRIATVvQPPFVQrTPDPLKGP-Nfe-gYCKDLIDLIKENIgNFTYILYEVEDGtFGTMdDN-GNWNGLMGALVSGSA 434  Pristionchus p...

7Z2R_A        80 DLAISAITITPERESVVDFSKRYMDY-SVGILIKK 113  Norway rat
XP_046441413 491 DIGLGALAVMAERENVIDFTVPYYDLvGISILMAK 525 
XP_008200796 497 DIGLGSMSVMAERENVIDFTVPYYDLvGITILMKL 531 
NP_001260050 495 DIGLGSMSVMAEREIVIDFTVPYYDLvGITIMMQR 529 
XP_002423441 455 DIGLGSLSIMAERENVIDFTVPYYDLvGITILMKK 489 
EFN61837     383 DIGLGSIWVMAEREKVVDFTVPYYDLvGLTIMMLK 417 
EFX71622     156 EIGVGPFSITHSRAKAVDFTVGFYED-AAAILIPP 189 
EFX79318      84 DIIAASLSVTYPRSQVVDFTFAFSED-PTSILIPY 117 
XP_011151040  80 DFAVAALWITHLRRQVVDYTIPFYKDnGFTIMMRR 114 
KAF8356358   435 DIALAPLSVMAERENDVDFTVPYYDLvGTTILMKK 469  Pristionchus pacificus
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap