Conserved Protein Domain Family
MAGUK_N_PEST
?
pfam10608: MAGUK_N_PEST (This model is not part of the current CDD release)
Polyubiquitination (PEST) N-terminal domain of MAGUK
The residues upstream of this domain are the probable palmitoylation sites, particularly two cysteines. The domain has a putative PEST site at the very start that seems to be responsible for poly-ubiquitination. PEST domains are polypeptide sequences enriched in proline (P), glutamic acid (E), serine (S) and threonine (T) that target proteins for rapid destruction. The whole domain, in conjunction with a C-terminal domain of the longer protein, is necessary for dimerization of the whole protein.
Links
?
Statistics
?
PSSM-Id: 519473
Aligned: 17 rows
Threshold Bit Score: 81.0648
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q28C55       107 KYRYPDDDI-TSQEPSSPHMLNDGR----NVELVQISEKNISQKENIQGLVSHSLISPLK-----------------TPE 164  tropical clawe...
ELK03786      11 KYRYQDEDT-PPLEHSPAHLPNQVN----APELVHVAERNLSHLEAVHGVVGHTHLSPLK-------------------- 65  
9_pfamImport   1 KYRYQDEDT-PPMEHSPAHLAGQVK----NPELVQVSEKNLSPIDNVHGYTPHTHLSPMKmetlsmtpqaspvkqswKAA 75  
5_pfamImport   1 KYRYQDEET-PPLEHSPAHLAPGK-----SAEMLHMSDKNLAAMEAIHGYTPHTHISPVKvgrvlvdpqtlslsrslTCP 74  
6_pfamImport   1 KYRYQDEET-PPLEHSPAHLAPGK-----SAEMLHMSDKNLAAMEAIHGYTPHTHISPVKvgrvltv------------- 61  
Q62936        27 PPGYGDWQVpDPYGPSGGNGASSGY----------------------GGYSSQTLPSQAGatptpr-----tkakliPTG 79   Norway rat
8_pfamImport   1 QYHYQEDDS-PLLDQGFPQLTSGLR----APELVHVSQKNLSEIENVHGFVSHSHISPLK-------------------- 55  
XP_005997201  96 KHKCQDEDS-LISDIRLPKYAESAQsfsqDPELVTVTSRSTELKESIYSVVSHSHIALPK-------------------- 154 
XP_047282462  35 KYRYQDEDA--PHDHSLPRLTHEVR----GPELVHVSEKNLSQIENVHGYVLQSHISPLK-------------------- 88   human
XP_029704547  55 KYRYQDEET-PPLEHSPAHLAPGK-----SAEMLHMSDKNLAAMEAIHGYTPHTHISPVK-------------------- 108  torafugu

Q28C55       165 ADTPCPPivpvipvi----------pvpaesnvIPSSTPQANPPPVIVNTD-LETPAYVNGTDAEYEYE 222  tropical clawed frog
ELK03786      66 ----------------------------------------ANSPPVIVNTDtLEAPGYVNGTEGEMEYE 94  
9_pfamImport  76 VFYQSAS--------------------------PKPPRGYANSPPVVVNTDtIDGSPYVNGTDGEVEYE 118 
5_pfamImport  75 LLLL--------------------------------ISLQGNTPPVVVNTDtLDGSPYVNGTEGEIEYE 111 
6_pfamImport  62 ------------------------------------------mkiksllTDtL--VCQVNGTEGEIEYE 86  
Q62936        80 RDVGPVPpkpvpgkntpklngsgpswwpectctNRDWYEQASPAPLLVNPEaLEPSLSVNGSDGMFKYE 148  Norway rat
8_pfamImport  56 ----------------------------------------ANPAPMIINTDtLESLPYVNGTEIEYEFE 84  
XP_005997201 155 ----------------------------------------AKPPPIIVNTDsLEHDPYVNGTDGVYKYE 183 
XP_047282462  89 ----------------------------------------ASPAPIIVNTDtLDTIPYVNGTEIEYEFE 117  human
XP_029704547 109 -PVLMSTght--------------------pmyTSAVSTLGNTPPVVVNTDtLDGSPYVNGTEGEIEYE 156  torafugu
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap