Conserved Protein Domain Family
CLTH

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pfam10607: CLTH 
CTLH/CRA C-terminal to LisH motif domain
RanBPM is a scaffolding protein and is important in regulating cellular function in both the immune system and the nervous system. This domain is at the C-terminus of the proteins and is the binding domain for the CRA motif (for CT11-RanBPM), which is comprised of approximately 100 amino acids at the C terminal of RanBPM. It was found to be important for the interaction of RanBPM with fragile X mental retardation protein (FMRP), but its functional significance has yet to be determined. This region contains CTLH and CRA domains annotated by SMART; however, these may be a single domain, and it is refereed to as a C-terminal to LisH motif.
Statistics
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PSSM-Id: 402305
View PSSM: pfam10607
Aligned: 115 rows
Threshold Bit Score: 55.27
Threshold Setting Gi: 74880122
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6VN20       291 SIKNRQKIQKLVLEGRVGEAIETTQRFYPGLLEHNPNLLFMLKCRQFVEMVNgtdsevrslssrspksqdsypgspslsp 370 human
Q54X16        67 SIADRMAIRSAIQCGDVEKGIEIVNDLNPEILDTNPQLYFHLQQQKLIELIR---------------------------- 118 Dictyostelium d...
Q8GYP0        61 SMNERLEVIKAIESRNLEDAIEKLNALNPEIIKTS----FHLHQQMLIELIR---------------------------- 108 thale cress
Q10PG5        81 tITDRMEVKRAVQSGNVQEAIEKINDLNPTILDTNPQLYFHLQQQKLIELIR---------------------------- 132 Japanese rice
A0DGB4        62 QMIERIEIKKNILDGDIDSALEKVNKKN------NNLILFKLKTQKLIELIK---------------------------- 107 Paramecium tetr...
A0DPL0        62 KMIERIEIKKNILNGEIDSALQKVSMSN------NKQILFKLKMQKLIELIK---------------------------- 107 Paramecium tetr...
XP_001609090  85 TISHRRRVKDAIISGNSTEARKLMDEIDPSILQKNVRIMFNLLANEVIDAIK---------------------------- 136 Babesia bovis T2Bo
XP_001614151  67 TVKIRYLIQSEIMNNKIEEAIEHINNLDKGILKKHKDLVFFLKKQQLLKLIL---------------------------- 118 malaria parasit...
Q4N9D2        77 TISERKFIRNSIMEGRIMDAINQINQIDRNILNENSNLLFVLMLYRLVDIIL---------------------------- 128 Theileria parva
XP_001025681  68 CMQPRIDIRKLILNGQIDEAINELDKINKKVLEENKDINFNIKLQKCIELIR---------------------------- 119 Tetrahymena the...
Q6VN20       371 rhgpssshmhNtgadspscsngvastkskqnhskypapsssssssssssssspssvnysesnstdstksqhhsstsnqet 450 human
Q54X16       119 ----------K--------------------------------------------------------------------- 119 Dictyostelium d...
Q8GYP0       109 ----------E--------------------------------------------------------------------- 109 thale cress
Q10PG5       133 ----------A--------------------------------------------------------------------- 133 Japanese rice
A0DGB4       108 ----------K--------------------------------------------------------------------- 108 Paramecium tetr...
A0DPL0       108 ----------V--------------------------------------------------------------------- 108 Paramecium tetr...
XP_001609090 137 ----------S--------------------------------------------------------------------- 137 Babesia bovis T2Bo
XP_001614151 119 ----------N--------------------------------------------------------------------- 119 malaria parasit...
Q4N9D2       129 ----------S--------------------------------------------------------------------- 129 Theileria parva
XP_001025681 120 ----------S--------------------------------------------------------------------- 120 Tetrahymena the...
Q6VN20       451 sdsememeaehypngvlgsmstrivngaykhedlqtdessmddrhprRQlcggnqaatERIILFGRElqalseQLGreyg 530 human
Q54X16       120 -----------------------------------------------GMt--------AEALKFAQD------ELApqge 138 Dictyostelium d...
Q8GYP0       110 -----------------------------------------------KKt--------EEAVAFAQE------KLAplae 128 thale cress
Q10PG5       134 -----------------------------------------------GKi--------NEALEFAQE------ELAprge 152 Japanese rice
A0DGB4       109 -----------------------------------------------DQi--------DQAVKYAQT------EIIpllp 127 Paramecium tetr...
A0DPL0       109 -----------------------------------------------NEl--------DQAVSYAQN------QIIdflk 127 Paramecium tetr...
XP_001609090 138 -----------------------------------------------GNv--------ALAIEYARN------KLApcvk 156 Babesia bovis T2Bo
XP_001614151 120 -----------------------------------------------NNi--------NEAILYSQQ------ELApyvn 138 malaria parasit...
Q4N9D2       130 -----------------------------------------------GDl--------HTAIKFAKE------EISscik 148 Theileria parva
XP_001025681 121 -----------------------------------------------EQi--------DKAISFAQE------ELLpile 139 Tetrahymena the...
Q6VN20       531 ----knlAHTEMLQDAFSLLAYSDPWSC-PVGQ-QLDP-IQREPVCAALNSAILESQNLPKQPPLMLALGQASECL-RLM 602 human
Q54X16       139 ----ennKFLEELEKTISLLVFEDTAK--SPLSsLLDH-SQRQKTAGELNSAILLSQSQDKDPKLPTILKLLKWAQtQLD 211 Dictyostelium d...
Q8GYP0       129 ----eneALQRELEKTVCILVTEGLPN--CPSReLFHN-SQWIRTASHVNEAIHTSQTGEKGPELERLLKELIWTQnQLD 201 thale cress
Q10PG5       153 ----enqVFLEEIEKTVALLVFEDIKNC-PYGE-LLDV-SQRLKTASEVNAAILTSQSHEKDPKLPSLLKMLIWTQnQLd 225 Japanese rice
A0DGB4       128 ----nqpHLIEEIEQAIALIAFSDIKK--SPMNhLVQN-SQRIKVASEINQHLYQDSMGNDQAKLRTLMKLLLWAQeILK 200 Paramecium tetr...
A0DPL0       128 ----dqpHLIDEIEKAMSLLAYKDLSK--CPLNhLTQN-SQRIKVASEVNQQLFQDSQGNEQAKITILMKILQWAQdILN 200 Paramecium tetr...
XP_001609090 157 ----eenALLEKLEAIMGLITFSDFNDPdVSQA-VNNI-QQLEHTAQMADVAILDYFGQESYVTLESLVKEAMWLQqQLS 230 Babesia bovis T2Bo
XP_001614151 139 ----ekpSLISEIDDVMMLMAYQDFNSe-EAKK-LIQKiEKKKNTLKRIDDIILSYYNVDSESTLEYIVKNIFFTQnVLS 212 malaria parasit...
Q4N9D2       149 ----kdpNLLTKLEEAMSLLAFQNLNSPeALEI-IKKI-QKPDEISNLVDNSLIAYYNLDPKPILENIIKETLWVEsQLE 222 Theileria parva
XP_001025681 140 ssnekkeLYQDSMEKVMSLLAFENLQE--SPYQdLVSN-SQRIKISSQINYEMLKGQQE-KENKLPTLIKLLLWSQdKLS 215 Tetrahymena the...
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