Conserved Protein Domain Family
GluR_Homer-bdg

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pfam10606: GluR_Homer-bdg 
Homer-binding domain of metabotropic glutamate receptor
This is the proline-rich region of metabotropic glutamate receptor proteins that binds Homer-related synaptic proteins. The Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R) that appears to be due to the proline-rich "Homer ligand" (PPXXFr). Activation of PI turnover triggers intracellular calcium release. MGluR function is altered in the mouse model of human Fragile X syndrome mental retardation, a disorder caused by loss of function mutations in the Fragile X mental retardation gene Fmr1. Homer 3 (and to a lesser extent Homer 1b/c) has been shown to form a multimeric complex with mGlu1a and the IP3 receptor, indicating that Homers may play a role in the localization of receptors to their signalling partners.
Statistics
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PSSM-Id: 402304
View PSSM: pfam10606
Aligned: 12 rows
Threshold Bit Score: 66.3265
Threshold Setting Gi: 1110898265
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_014325582 1115 LSPPSPFRD-SLCSGDSANGSP-IIDSLLG----------S---SVYTSNILQNFAHSSSTL 1161 southern platyfish
XP_013766679 1129 LSPPSPFRD-SVYSGDSVTGSP-IIDSMLG----------Sp--SVYTADILRDYAHSSSTL 1176 Pundamilia nyererei
XP_019200814 1179 LTPPSPFRD----SLASSSGSP-VSERDLClppvpshpppSppsPRYTRLTLRNYSQSSSSL 1235 Nile tilapia
XP_007248661 1163 LTPPSPFRD-SVASGSGSPNSPgGSEMGLG----------PtpsPKYECLVLRHYSQSSSSL 1213 Mexican tetra
XP_007247323 1137 LTPPSPFRDsSMGSASDSPTSP-DSELALC----------QpcsPKYDRLMLRNYSQSSSSL 1187 Mexican tetra
EHA98964      736 LTPPSPFRD-SVASGSSVPSSP-VSESVLC----------TppnATYASVILRDYKQSSSTL 785  naked mole-rat
PWA29607     1128 LMPPSPFRDcSGTPVSPFPNSP-VSESVLC----------TppnVTYASVILGDYKQSASTL 1178 western mosquitofish
CAG13194     1173 LMPPSPFRDcVCPPVSPFSNSP-MSESILC----------GplnATYTSAVLGDFKQSSSTl 1223 spotted green pufferfish
XP_005477397 1126 LMPPSPFRDcTGAPVSPFPNSP-VSESILC----------TppnVTYASVILRDYKQSSSTL 1176 Nile tilapia
XP_011610469 1055 LSPPSPFRD-SVCSGESASGSP-VMEPMLG----------KapsSFYTSDIYGDYAHSSSTL 1104 torafugu
XP_004083645 1109 LSPPSPFRD-SVCSGESINGSP-VIEPMLG----------SppsSVYTSDMLRDFAHSSSTL 1158 Japanese medaka
XP_016093318  914 LTPPSPFRDsSVDSISESPTSP-ASELPLC----------EpcsPIYDQLVLRHYSQSSSSL 964  Sinocyclocheilus grahami
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