Conserved Protein Domain Family
GluR_Homer-bdg
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pfam10606: GluR_Homer-bdg 
Homer-binding domain of metabotropic glutamate receptor
This is the proline-rich region of metabotropic glutamate receptor proteins that binds Homer-related synaptic proteins. The Homer proteins form a physical tether linking mGluRs with the inositol trisphosphate receptors (IP3R) that appears to be due to the proline-rich "Homer ligand" (PPXXFr). Activation of PI turnover triggers intracellular calcium release. MGluR function is altered in the mouse model of human Fragile X syndrome, a disorder caused by loss of function mutations in the Fragile X messenger ribonucleoprotein 1 Fmr1. Homer 3 (and to a lesser extent Homer 1b/c) has been shown to form a multimeric complex with mGlu1a and the IP3 receptor, indicating that Homers may play a role in the localisation of receptors to their signalling partners.
Links
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Statistics
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PSSM-Id: 431390
Aligned: 12 rows
Threshold Bit Score: 38.5985
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_014325582 1114 ALSPPSPFRD-SLCSGDSANGSP-IIDSLLG----------S---SVYTSNILQNFAHSSSTL 1161
6_pfamImport    1 ALSPPSPFRD-SVYSGDSVTGSP-IIDSMLG----------Sp--SVYTADILRDYAHSSSTL 49  
5_pfamImport    1 ALTPPSPFRD----SLASSSGSP-VSERDLClppvpshpppSppsPRYTRLTLRNYSQSSSSL 58  
XP_049323046 1162 PLTPPSPFRD-SVASGSGSPNSPgGSEMGLG----------PtpsPKYECLVLRHYSQSSSSL 1213
8_pfamImport    1 ALTPPSPFRDsSMGSASDSPTSP-DSELALC----------QpcsPKYDRLMLRNYSQSSSSL 52  
EHA98964      735 ALTPPSPFRD-SVASGSSVPSSP-VSESVLC----------TppnATYASVILRDYKQSSSTL 785 
7_pfamImport    1 ALMPPSPFRDrSGTPVSPFPNSP-VSESVLC----------TppnVTYASVILGDYKQSASTL 52  
3_pfamImport    1 ALMPPSPFRDcVCPPVSPFSNSP-MSESILC----------GplnATYTSAVLGDFKQSSST- 51  
4_pfamImport    1 ALMPPSPFRDcTGAPVSPFPNSP-VSESILC----------TppnVTYASVILRDYKQSSSTL 52  
XP_004083645 1108 ALSPPSPFRD-SVCSGESINGSP-VIEPMLG----------SppsSVYTSDMLRDFAHSSSTL 1158
XP_029705762 1120 VLSPPSPFRD-SVCSGESASGSP-VMEPMLG----------KapsSFYTSDIYGDYAHSSSTL 1170 torafugu
NP_001315639 1122 VLTPPSPFRDsSVDSISESPTSP-ASELPLC----------EpcsPIYDQLVLRHYSQSSSSL 1173 zebrafish
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