Conserved Protein Domain Family
zf-LITAF-like
?
pfam10601: zf-LITAF-like (This model is not part of the current CDD release)
LITAF-like zinc ribbon domain
Members of this family display a conserved zinc ribbon structure with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumour necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS). The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure.
Links
?
Statistics
?
PSSM-Id: 519469
Aligned: 280 rows
Threshold Bit Score: 37.19
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_002115291   35 ESTQTMDCPFCNQQIQTVIRYEAGEGTCTTaalCcCFLFLTSIgpyirgiiglLIV-FCCNSFQDIKHYCPECQKLIKAY 113
XP_013940295   91 ESPDYIDCPYCKSRQKTEVRHQSTSQTSLA---A-AVCCLCCGil-------pVFIpFVCNWCSDLDHHCESCKKRVAHQ 159
XP_007807282   82 DQPQWIDCPFCHQRTTTTVQREGTSMQIIV---G-ALLCLFCic--------lTCVpCLAGWFEDTQYRCSQCKNMVAIG 149
21_pfamImport   1 DSPQWIDCPFCHRRTLTRVSKEGTSMQILA---G-ILCCLFCvc--------lACVpCLAGWFEETIYVCTQCNKKVATR 68 
20_pfamImport   1 GGPQWIDCPFCQRRTQTRVEKDGGGTQVLV---G-FLCCLVCvc--------lACVpCLAGWFEEWNYYCTGCGQRVACK 68 
Q2GR46         81 DQPQWIDCPFCQQRTMTRVATEGTSMQIVA---G-VLCCLLCvc--------lACVpCMAHWFEETNYFCSKCHNKVATR 148 Chaetomium glo...
EQB59212      115 GKPQPIDCPFCMRRTMTIVDTEGTGMQMLA---G-ALCCLLCvc--------lTCVpCIAGWYEDTHYSCGNCHKRVATR 182
XP_003850718   10 EHSAEVDCPFCQRRAMTRVGEEHSTMTWLS---G-VVLGFFCic--------lACLpCIAHSCQEIDHYCGNCGKQLTHR 77 
XP_003713473   58 PAPAVVDCPFCQQRVMTRVNEEHSSMTYLL---G-VLIGCICic--------aACVpCLAHMCQDVTHFCTNCNQRVAHI 125
29_pfamImport   1 DEPARICCPFCLQKVQTRVNKESTSATSMA---A-VCCCLFGGic-------cAFLpFCMEMCHDSHHFCTNCGVEVAIH 69 

XP_002115291  114 E 114
XP_013940295  160 P 160
XP_007807282  150 R 150
21_pfamImport  69 P 69 
20_pfamImport  69 K 69 
Q2GR46        149 P 149 Chaetomium globosum CBS 148.51
EQB59212      183 P 183
XP_003850718   78 P 78 
XP_003713473  126 P 126
29_pfamImport  70 P 70
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap