Conserved Protein Domain Family
zf-LITAF-like

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pfam10601: zf-LITAF-like 
LITAF-like zinc ribbon domain
Members of this family display a conserved zinc ribbon structure with the motif C-XX-C- separated from the more C-terminal HX-C(P)X-C-X4-G-R motif by a variable region of usually 25-30 (hydrophobic) residues. Although it belongs to one of the zinc finger's fold groups (zinc ribbon), this particular domain was first identified in LPS-induced tumor necrosis alpha factor (LITAF) which is produced in mammalian cells after being challenged with lipopolysaccharide (LPS). The hydrophobic region probably inserts into the membrane rather than traversing it. Such an insertion brings together the N- and C-terminal C-XX-C motifs to form a compact Zn2+-binding structure.
Statistics
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PSSM-Id: 402300
View PSSM: pfam10601
Aligned: 317 rows
Threshold Bit Score: 36.0149
Threshold Setting Gi: 74954853
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002115291  36 STQTMDCPFCNQQIQTVIRYEAGEGTCTTaalCcCFLFLTSIgpyirgiiglLIV-FCCNSFQDIKHYCPECQKLIKAYE 114 Trichoplax adha...
XP_007274604  75 FPALVECPGCKGVAPTTTEHTIGKGTHWM---AvMFFCTTGVg---------VFIpYSMKPFKNVRHNCMRCGRVLATNR 142 Colletotrichum ...
XP_002912040 114 DPAPAQCPSCGKRMVTNIRHTVGTTTHLW---A-GVALAVAcv--------pC-IpYCLDSTKDVKHSCTQCGTLLATWR 180 Coprinopsis cin...
CAZ81106      87 SPAPVQCPVCNARGLTVVTYEIGNTTHLA---A-LLLCFVTsl--------gC-IpYMFNAFKDVAHSCASCRTMLAVWH 153 Perigord truffle
ENH84990     114 HPAPVECPECHARGVTAVEYSSGGFTHAL---A-ALVCFVScl--------gC-IpYFFSSLKDARHKCAKCGIPLATYH 180 Colletotrichum ...
XP_003054719  91 QSAPVVCPSCGVRDFTVTTAEAGGFTHAA---A-ALVCFVScl--------gC-IpYCISSLKDVHHRCANCGVPLADYH 157 [Nectria] haema...
CCT69336      80 mSAPVVCPVCEVRAMTITTAKSGGVTFAA---A-GIACLLSCai-------lSWVpFFISDAKDVLHQCGNCKVYLAQWH 148 Fusarium fujiku...
EGU77178      58 lSAPVVCPKCGVRAMTITRVKSGSFTLAL---AgIAFITTCWl--------lIPLpFLMSSTKDVLHQCGNCKILIAEWH 126 Fusarium oxyspo...
CEF75951      88 QSAPVVCPSCGVRAMTVTKAESGGMMHAV---A-AGVCFFTcl--------gC-IpYCIESLKDVHHQCGNCNMPLASYH 154 Fusarium gramin...
EDN98652     157 ESRLVRCPRCGVLEYTQVEWVSGGTADIS---A-LICCFCFcl--------pC-IpYLMTSFKDVHHKCGNCGVLLAIWK 223 Sclerotinia scl...
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