7KBU,1SRA


Conserved Protein Domain Family
SPARC_Ca_bdg

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pfam10591: SPARC_Ca_bdg (This model is not part of the current CDD release)
Secreted protein acidic and rich in cysteine Ca binding region
The SPARC_Ca_bdg domain of Secreted Protein Acidic and Rich in Cysteine is responsible for the anti-spreading activity of human urothelial cells. It is rich in alpha-helices. This extracellular calcium-binding domain contains two EF-hands that each coordinates one Ca2+ ion, forming a helix-loop-helix structure that not only drives the conformation of the protein but is also necessary for biological activity. The anti-spreading activity was dependent on the coordination of Ca2+ by a Glu residue at the Z position of EF-hand 2.
Statistics
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PSSM-Id: 519464
Aligned: 20 rows
Threshold Bit Score: 117.04
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7KBU_A        82 IPTCTDFEVIQFPLRMRDWLKNILMQLYEANSEHagylnekqrnkvkkiyldekrllagDHPIDLLLRDFKKNYHMYVYP 161 human
EDO37293     110 VSECARDNLLQFGERYLEWILISRRRLVNRYYQV-----------------------------KESEKGHNLPPDMRKEL 160
EDO34342     109 MTDCPKWMLEQFPYRFLDWLYLTRELSRDPRFEI-------------------------------AKRGEQLTGDEIKEV 157
Q08629       195 RSACTDKELRNLASRLKDWFGALHEDANRVIKPT--------------------------SSNTAQGRFDTSILPICKDS 248 human
6_pfamImport   1 KKVCSESELKEVVSRLRDWFRVLHENGNHKRVKI---------------------------QKPEKSKFEVGASPICKDP 53 
Q5RD69       198 KRACSDLEFREVANRLRDWFKALHESGSQNKKTK-------------------------TLLRPERSRFDTSILPICKDS 252 Sumatran orangutan
NP_001091924 148 MGSCSAEDLREYPERMTNWFIKSLALIRNRPEEH-------------------------GGLSQKEKETLQQEWSQSTHA 202
XP_029703408 186 RDSCTGQDLADLGDRLKDWFQLLHGNAKQNNSGK--------------------------LGSGTSSALDRSLEASCKDS 239 torafugu
XP_029703255 209 RAGCTDSELHSLAARLKDWFRILHLDTNRDLKSS-------------------------DNSDSTAGHFDTSILPICKDS 263 torafugu
XP_018080884 194 GETCTGQDLADLGDRLRDWFQLLHENSKQNNTLN--------------------------PGSKQVNVLDKSLVAGCKDS 247 African clawed ...
7KBU_A       162 VHWQFSELDQHpMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHC 220 human
EDO37293     161 AQWEFDRVDFN-RDGVLSGREINSIIGPLLFHERCIYGFVMSCDVNKNSVIDKQEWLLC 218
EDO34342     158 LAWEFNNWDLN-KNGIWDKEELDLVQTILMPIEGCSFGFLKSCDLDGKGDMDRREWMMC 215
Q08629       249 LGWMFNKLDMN-YDLLLDPSEINAIYL--DKYEPCIKPLFNSCDSFKDGKLSNNEWCYC 304 human
6_pfamImport  54 LGWMFSRLDTN-FDLQLDQSEIRSLYL--DRNEPCSDAFFRSCDTHPDKVITSSEWCTG 109
Q5RD69       253 LGWMFNRLDTN-YDLLLDQSELRSIYL--DKNEQCTKAFFNSCDTYKDSLISNNEWCYC 308 Sumatran orangutan
NP_001091924 203 IFWKFDRLDKNpSDHYLDFAELEGLRAPIVLFEPCTKPFLQACDVDNDTLISAVEFGRC 261
XP_029703408 240 IGWMFSKLDTN-NDLYLDQSELTAINL--DKYEVCIRPFFNSCDTYKDGKISMAEWCLC 295 torafugu
XP_029703255 264 LGWMFNKLDMN-FDLLLDQSELSALYL--DKYETCMKPLFNSCDSFKDGKLSNNEWCYC 319 torafugu
XP_018080884 248 IGWMFSKLDSN-NDLFLDEAELAAINL--DKYEICIRPFFNSCDTYKDGRVSTAEWCFC 303 African clawed frog
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