Conserved Protein Domain Family
Involucrin_N

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pfam10583: Involucrin_N (This model is not part of the current CDD release)
Involucrin of squamous epithelia N-terminus
This is the N-terminal three beta strands of involucrin, a protein present in keratinocytes of epidermis and other stratified squamous epithelia. Involucrin first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane. Apigenin is a plant-derived flavanoid that has significant promise as a skin cancer chemopreventive agent. It has been found that apigenin regulates normal human keratinocyte differentiation by suppressing it and this is associated with reduced cell proliferation without apoptosis. The downstream part of the protein is represented by the family Involucrin, pfam00904.
Statistics
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PSSM-Id: 519458
Aligned: 9 rows
Threshold Bit Score: 75.6836
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_051714615   1 MSEQHTLPVTLPpALCQEILKTVPPPAAFHQEQMVQPTPLPAPCQKVPCELPVEVISNLEEKHANPVNG 69 
XP_027241385   1 MSQQHTLPVTVP-SVVQESLKTVCPPAQLKLEQTKQPTSQPALCQKVFSETQEKGSTQQEEKGTTVEGL 68 
P48997         1 MSHQHTLPVTVP-AVVQGPLKTVCSPDHIQQEQAKQPTPHPTQCQ-VFTEIQEKGFPKHEEKRPNPVKD 67  house mouse
NP_999613      2 MSQQYTLPVTLPpALSQEPLKPVSPPADTQQEQVKQATPLPAPCQKMLSELPVEVPLEDAEKHTTLVKG 70 
3_pfamImport   1 MSQQHTLPVTLPpALCQEPLKPVCPPINTQPEQVKQPTPLPALCQKMPSKLPGEVHQEHGENHTTLVKG 69 
P18174         1 MSQQHTLPVTLPpALSQGPLKPESPPIDTQQEQVKQPTSLPVLCQKMPSSLPGKVPLGHGEKHTSLVKG 69  dog
1_pfamImport   1 MSQQHTLPVSLPaVLSQQPLKTVSPPLDTQQEQVKQPTPLPAPCQKVPSELPVEVPWEQGEKYTAPVKE 69 
XP_015453793   1 MSQQTTLPVTLPpALRQQPLESASPPADTQQEQAKQPTLPPGPCQKVPPELPGEVPSVHREKHAAPGKG 69 
P24710         1 MSQQHTLPVTLPpALRQELLGTLSPPAAAQQEQRKQPTPLPTACQKVGSELPGEVPSKHEEKGTDPVKG 69  thick-tailed bush baby
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