Conserved Protein Domain Family
FAM171A1-2-B_N
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pfam10577: FAM171A1-2-B_N (This model is not part of the current CDD release)
FAM171A1/A2/B, N-terminal
This a domain found at the N-terminal of a family of proteins that includes FAM171A1/A2 and FAM171B. FAM171A1 is a type 1 transmembrane glycoprotein also known as astroprincin (APCN) due to abundant expression in astrocytes. APCN is also expressed in placental trophoblasts, skeletal and heart muscle, kidney and pancreas. APCN is involved in the regulation of the cytoskeletal dynamics, playing a role in actin stress fiber formation.
Links
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Statistics
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PSSM-Id: 519455
Aligned: 12 rows
Threshold Bit Score: 442.225
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_012827003  43 VHIKVQVYENGDLSPLASAAVEIFGNQSA-LASGVTDQDGIAVLGISYRLGTWVLVTATKRGYVTNSVPWRVDRLPrkhL 121
XP_002939068  36 VTLKVQVSDVSTHQPIADAVIEIFANQVS-AASGTTGADGTALVKLQYKLGSQLIVTATKQAYVPNSAPWRPLRLP---V 111
NP_001333996  29 VTLKVHISDASTHQPIADALIEIFASQVS-VASGTSGTDGVAFIKFPYKLGNQLIVTATKQAYVPNSAPWKPIRLP---V 104
XP_069050891  12 VTLKVHVSDASTHQPISGASIEIFTNQTS-FTSETSGADGNAFIKFHYRVGTLLIVTATKHGYVPNSSPWRPEKLP---V 87 
1_pfamImport   1 VTLKVHLSDASTHQPLGGATVQLFTNHTP-VTTETSTPDGNAYLRFPYRLGTQLVVTATKQGYVPNSVPWTPSRLP---V 76 
A2A699        41 ILIKVQVYVSGELVPLARASVDVFGNRTL-LAAGTTDSEGVATLPLSYRLGTWVLVTAARPGFLTNSVPWRVDKLP---L 116 house mouse
XP_015217836  35 VFIRVQVFDNSDLSPLARAAVEVYGNQST-LASGVAGDDGAVAVRFQYRPGTWVIVTASRQGFVTNSAPWHASRIP---L 110
XP_001337555  34 VQVRVQVFDGGDLSPLPNAALAVHGNQSL-LAQSRAGSDGVQVVSFTYRTGTWVIITASQRDYLTSSVPWHASRLP---L 109
XP_684281     35 VLIKVQVFDNSDLSPLRESTVQVCGNQTI-LASNLVGEDGIVTLTFLYRPGTWVIVTASKHGFVTNSAPWHASRVP---L 110
XP_003961159  31 VQIKVQVFDNSDLSPLADARVEVHGNQSAiLASVRADGDGVVRVGFLYRTGSSVIITASKRNYVTNSVPWHSSRIP---L 107 torafugu
XP_011603945  43 VTLKVHLSDASTHQPLSGVTVQLFTNHTS-VTTETTSADGNTYLRFPYRLGTPSLVVATKPGYVPNSVPWTPSRLP---V 118 torafugu
XP_005992281  37 VLIKVQVFDNSDLSPLFHASVDVYGNQSS-LASGITDGDGVVTITFQYRPGTWIIVTAAKYGFVTNSAPWHVDRIP---M 112 coelacanth

XP_012827003 122 YASVSLYLVPERPATLILYEDIVQILLGSPGVRSQPWVQFQRKAARLPRSSTYNQLTSSLTTASNLHQMRGFPSFIGTEP 201
XP_002939068 112 FSSLSLGLLPERSATLMVYDDIVQIVSGFQGSRLQPRVHFQRRALNLPGNATYKDLTAFLTAASAPWEIDSFPYLQGSDG 191
NP_001333996 105 FSSLSLGLLPERSATLMVYEDVVQIVSGFQGARPQPRVHFQRRALRLPENTSYSDLTAFLTAASSPSEVDSFPYLRGLDG 184
XP_069050891  88 FSSLSLDLLPERSATLMVYEDLVQIVSGFQGTRVQPRVQFQRTSLSLPPNATYSNLTAFLTAADSTWEVDSFPYLQGVGG 167
1_pfamImport  77 FSSISLDLLPERAATLMVYEDIVEIVSGLQGLRPQPRVDFQRGALTLPSNISYANLTALLTVASSPSHIQYFPHLQVLSG 156
A2A699       117 YASVSLYLLPERPATLILYEDLVHILLGSPGARSQPWVQFQRRAARLPVSSTYSQLWASLTPASTQQEMRAFPAFLGTEA 196 house mouse
XP_015217836 111 YASVSLYLLPQRPATLILYDDVVQVLLGSPGARNQPWVQFQRKAVRLPLNSTYTELSAVLTSAKSQYEIGGFPYLLGQES 190
XP_001337555 110 YASVSLYLMAQKPGTLILYDDVIQVFHGSPSGRSQPWLQVPRRSLQF--NSSYTELTAVLTTAREQNEINSFPYPLALEP 187
XP_684281    111 YASVSLYLLPQRPATLLLYDDVVQLLLGSPGSRRQPWVQLQRRAIQPPLNNSQITLSAMLTSSRSQYELGGFPYPLAMDN 190
XP_003961159 108 YASVSLYLLAQRPGTLILYDDVLQVLSGSPGARNQPLVQLQRKSLLLPPNNNYTALSAALTTARTQYEIGGFPFLLGQEG 187 torafugu
XP_011603945 119 FSSISLDLLPERTATLMVYEEVVEIVSGLQGFRHPPIVNFPRRALTLPFNTSYADLTALLTVASSLSHIQHFPHLQAVDG 198 torafugu
XP_005992281 113 YASVSLYLLPERPATLILYEDVVQILLGSPGSRNQPWVQFQRKAVRLPENSTYSHLSAFLTAASSEYEIGGFPYLVGLES 192 coelacanth

XP_012827003 202 ESSngGNTSWVELLPVAAVSVHLFTGNGSEVHLSGPVQLSLPLPPE-SGLTTSSSVPAWRYEPKAGLWIRSGMGMVRRDG 280
XP_002939068 192 NST--GNNSRFDLTPVTAVSFHLLNSDGADIPVNGPIYVTVPLPMH-SSLKHNAHVPAWRFDQKHGTWLKSSIGIIQQEG 268
NP_001333996 185 NGT--GNSTRYDLTPVTAVSVHLLSGNGMPVLVDGPIYVTVPLATQ-SSLRHNAYVAAWRFDQKLGTWLKSGLGLVHQEG 261
XP_069050891 168 NGT--GNNRRFQLTPITAVSIRLLSSDGTEIQVTGPIDVTVPLPAN-SNLKENDHIPAWRFDSKLGAWRKSSLGFVLKEE 244
1_pfamImport 157 NGTa-GTEERFELTPVAAISVHLLAGDGVELQVNGAITVSVPLPAN-SGLKENDHIPAWRFDPRLGAWIKSSWCHVQRDG 234
A2A699       197 SSS--GNGSWLELIPLAAVSVHLLTGNGTEVPLSGPIHLSLPVPSEpRALAVGTSIPAWRFDPKSGLWVRNGTGVIRKEG 274 house mouse
XP_015217836 191 NGTg-GNGSWLDLTAVAAVSAHLFTRNGTLIQVSDPVHISIPMPSD-SPVRVATSIPAWRFDSKTGVWVRNGTGYIKKEG 268
XP_001337555 188 NNTg-GENGWTDLTTIAAVSAQLFDREGRAVEVSEPVHISVPLPSD-THIRSASSIPVWMYDTKTGLWVRNGTGFIIREG 265
XP_684281    191 NSTg-TNSSWVELTALAAMCAQLTGPNGTEVQVSEPIHISIPLPSD-SPLKTATSVPVWRFEDKTGLWVRSGAGYIKKED 268
XP_003961159 188 NSS---ETGWTDLVALAVISVQLFDKDGGAIQVSDPIHVSVPLPSD-THNRMATSVPVWLYQPQTGLWVRNGTGYIQKDG 263 torafugu
XP_011603945 199 NST--GTEKRFELTPVAAISVHLLASDGTELQVNRPISVSIPLPAD-SDLKENDEIRAWRFDPQLGAWLKSNWGHVRREG 275 torafugu
XP_005992281 193 NGT--GNSSWLELTPVAAVSVHLFIGNRSEVQLSAPVHVSIPLPGD-SPLLATTNVPAWRFHPKSGIWVRSGTGQIKREG 269 coelacanth

XP_012827003 281 QQLYWSFVSPKLGYWAAAIPS 301
XP_002939068 269 SQLTWTYIAPQMGYWVAAMSP 289
NP_001333996 262 SQLTWTYIAPQLGYWVAAMSP 282
XP_069050891 245 DQLILKYIAPQLGYWVAAMSP 265
1_pfamImport 235 NRLSLTYIAPQLGYWVAAMSP 255
A2A699       275 RQLYWTFVSPQLGYWVAAMAS 295 house mouse
XP_015217836 269 AQLTWSFVAPQLGYWIAAVPS 289
XP_001337555 266 SQLRWDFTASQLGYWIAAFRA 286
XP_684281    269 TQMTWSFVAPKLGYWLAAFPS 289
XP_003961159 264 SQFVWNVMVAQMGYWLAAFPS 284 torafugu
XP_011603945 276 NQLILTYIAPQLGYWLAAMSP 296 torafugu
XP_005992281 270 TQLTWNYVASQLGYWMAALPS 290 coelacanth
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