Conserved Protein Domain Family
Nab6_mRNP_bdg

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pfam10567: Nab6_mRNP_bdg 
RNA-recognition motif
This conserved domain is found in fungal proteins and appears to be involved in RNA-processing. It binds to poly-adenylated RNA, interacts genetically with mRNA 3'-end processing factors, copurifies with the nuclear cap-binding protein Cbp20p, and is found in complexes containing other translation factors, such as EIF4G.
Statistics
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PSSM-Id: 402276
View PSSM: pfam10567
Aligned: 9 rows
Threshold Bit Score: 320.544
Threshold Setting Gi: 74606631
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002498602  218 TYRMLPKGDDEYRTRSLLFENVNGSVDLYS-FVSKYSRYGPVESIYMFKDRN--------DKTK---------------- 272  Zygosaccharom...
XP_003954856  184 SYVILPKGDDAYRTRSLLFENVDNAINLHS-FITNFVKNNSIESIYLVPNKN--------DSNT---------------- 238  Kazachstania ...
CCK71402      163 SYKILPKGDDLYRTRSLLLGNIDDMVDLHT-FVSKFVQNNSVESVYITKEGQ--------QPEK---------------- 217  Kazachstania ...
Q6CSF4        218 QYSILPKGNDTYRSRSLLFTNVNSELDIVE-FLQKVAKNYPIESIYLIKDEDtgddienlNTSNndddpnqnynadnnnn 296  Kluyveromyces...
Q6FXF4        295 NYRVLPSGDDTYKTRSLLFENVQKNDEMLSvFMRLIINYSQVESVYVFQQTDtpskdkesDKDT---------------- 358  [Candida] gla...
XP_003674489  180 SYKILPSGDDAYRTRSLLFENVVNSIELHT-FMTEFVRFSPIESVYLINHHDsdk--pddDTEC---------------- 240  Naumovozyma c...
XP_003686968  213 SYQILPKGDDTYHTRSLLFENINESIDLHT-FIEKFVNYGLIESVYVVPSYEt------hQNSV---------------- 269  Tetrapisispor...
XP_003679394  169 TYRVLPKGNDEFRTRSLLFENVDGSIDLHS-FVTNFTNYGPVESVYLFKS----------EGDH---------------- 221  Torulaspora d...
CDF89572      177 SYKMLPKGDDEYRTRSLLFENVNSSVDLYS-FVSKYSKYGPVESIYMFRNRA--------DKSK---------------- 231  Zygosaccharom...
XP_002498602  273 ----------------------------HSVLLSFLSRKICLDSYNSVLQRLAEFKTGLKSKSLTVSFVSLKY-R----- 318  Zygosaccharom...
XP_003954856  239 ----------------------------CDIILSFLSRHICLDFYNNVLQRLKEFKKHLNSESLNLNFVSLKY-N----- 284  Kazachstania ...
CCK71402      218 ----------------------------YGFLLSFLSVQICLNFYNNVLQRLKEFKEQLKASSLELSFVSMRQ-Rptkve 268  Kazachstania ...
Q6CSF4        297 skreddkdkesapaltkqiaispsscsqQSYLLSFFTKESCLDFYNNLLQRYAEIKNAVKSDQLAMNFVKIQ-------- 368  Kluyveromyces...
Q6FXF4        359 ----------------------------CCLQLSFLSRQAALDFYNNFLQRLPDFKKKLSSPKLSVSFVSFSY------- 403  [Candida] gla...
XP_003674489  241 ----------------------------RSILLSFLTREVCLTFYNNVLQRLKEFKAKLKSENLRLSFVSIKY-Q----- 286  Naumovozyma c...
XP_003686968  270 ----------------------------KSILLSFTSRSICLDFYNSVLQKLSEYKTQLNSENLKLSFVSLCYlQnnink 321  Tetrapisispor...
XP_003679394  222 ----------------------------VSILLSFFSKAICLDFYNSVLQRLSEYKSDLDSKALTLSFVSLEY------- 266  Torulaspora d...
CDF89572      232 ----------------------------NSVLLSFLSRKICLDSYNSVLQRLAEFKTGLKSKSLTVSFVSLKY-K----- 277  Zygosaccharom...
XP_002498602  319 ------KHVDENEvdqndnssstpmnetddtdasktpvatsnvqddaynvtvVASLQYDIVNR-GATRSVALELDGE--- 388  Zygosaccharom...
XP_003954856  285 ------KTTRDNQ---------------------------------------GPSLEFNIVTR-DATRSLAIELCSNend 318  Kazachstania ...
CCK71402      269 gkiyrrFAADDGDg--------------------------------------MANLHFDMAAQtGATRSIAIEFVDKdv- 309  Kazachstania ...
Q6CSF4        369 ---------DDEEw--------------------------------------MANLKMNVISL-GATRSLYVEFADDs-- 398  Kluyveromyces...
Q6FXF4        404 ------VTDEDKDkdkdkdkdinte---------------krnikrsqellkEPALGEEIFSH-DATRSIAIEFYSQ--- 458  [Candida] gla...
XP_003674489  287 ------DENEEEEtnivde----------------------------psfytKESVYFELSNP-QATRSILIQFKNP--- 328  Naumovozyma c...
XP_003686968  322 gngkisVESQKNEtdf----------------------------------elTSLIQYQVANF-GATRSLCIEFDKR--- 363  Tetrapisispor...
XP_003679394  267 ------KVSDTSEedidkedds---------------------kpdafnitaAGSLRYDVINR-GATRSIMITFKTP--- 315  Torulaspora d...
CDF89572      278 ------RHVEPEEedqigedndpg------------------dgddaynvsvVASLQYDIVNR-GATRSLALNLDDE--- 329  Zygosaccharom...
XP_002498602  389 ---YDK-TKLLDQEL-DFLSPANNQRYVLESIYLINAKEPFKHFPKNYAILTFLNISMAVEVLDYVRNNEtARSKFQKCF 463  Zygosaccharom...
XP_003954856  319 sliLEK-EQLFEKILnEILRTDENKRYVLESIDLVSTDKSNKEFGKNYAILSFLNITMAIEIMDYIQVIS-SKLNIGKCS 396  Kazachstania ...
CCK71402      310 --iLTR-DELLNKKL-KFLSEGNN-RYILEHIAVFKTQHGTKVFGKNYAIITFLSIPMAMEIMDYLKLNI-KQLHLTKFF 383  Kazachstania ...
Q6CSF4        399 ---VTS-DTIWDT-L-PFLK--NSGKYVVIDVDVVTTDERRKNFGLHYCLLHFLSVTMALEVKELLET---GDEAVSRVS 467  Kluyveromyces...
Q6FXF4        459 ---VEQ-DALFEK-L-PFLDDKDNKRYILEAVDIISAEDAADDFPANYVILTFINIKMAIEVLDYLKANL-MTYSVNECF 531  [Candida] gla...
XP_003674489  329 ---CSE-QELFDKKL-KFLNQENNSRYILESIDLVNVTQTENEFPKHYAILTFINILMAMEICDYLKIHG-PRYGIQDCM 402  Naumovozyma c...
XP_003686968  364 ---VDKiDDFIETYL-PFLSSNANKRYIIESLYIVNNNGKDNEFPAHYVILSFLNISMVIEVLHYIRSKN-LSKTIKNCL 438  Tetrapisispor...
XP_003679394  316 ---CSK-DELIDKKL-EFLKKENNTRYVLESIDLVTADEPSKHFPQNYAVLTFLNIFMAVEILDYIRLHS-QKLDISKCF 389  Torulaspora d...
CDF89572      330 ---CDK-DELLKNRL-DFLSPSKNQRYVLESIYLIKAKEATRHFPKNYAILTFLNISMAVDVLDYLRNSE-QNFESSQCF 403  Zygosaccharom...
XP_002498602  464 FVSVSSCP------QTSS--------DggivttsnsitpvaSGGSAGIATNGdlggytsKNA--SLSSLNSVgs-yISLD 526  Zygosaccharom...
XP_003954856  397 FVTIQPLIennvmnNSSAlssatniqSsv-----------sSEGNNNQNNNGstf--fhKNSinSLLSSESS----VSID 459  Kazachstania ...
CCK71402      384 YVQVTHPP------QQSPaasqkkphAndte-------snrDTSPPNSKKDQef---fpNNSmlSLVSSESS----TSLA 443  Kazachstania ...
Q6CSF4        468 FVTPANSAdkemrrRRSSaislkqeaSpqmfstdsrsrsrsSNVSLPLSEQV------------STASTDIS----TPIY 531  Kluyveromyces...
Q6FXF4        532 FVSLPGCKsq---rESSTtpvlghisTegs-------------------------------ksvSEVNLANGgn-tVMID 576  [Candida] gla...
XP_003674489  403 FVQVIPKA------VSCVsskrasiiSkdnd-------nndETLSSQQKKNDi-----lKNS--SIISLPSAendqVSDE 462  Naumovozyma c...
XP_003686968  439 YVSFDRTK------HAVSnsnrqslsKkgts------------------------------dtlNTYTLESP----INHN 478  Tetrapisispor...
XP_003679394  390 FISIQPQIpdgkrlSVSSasngrsmeSisgn-------------------------yrsKNA--SVTSLESSgs-iISLD 441  Torulaspora d...
CDF89572      404 FVSVSPHS------QPSFesntsfdhTggak-------nnsAGGLVGNAPNGnlgsytsKNA--SLSSLNSFgs-yISLD 467  Zygosaccharom...
XP_002498602  527 QEIDF-------------LSSSLKG----SHTITVAVDEYPKPFFAEFSDHL 561  Zygosaccharomyces rouxii
XP_003954856  460 EEVIS-------------IADKLKGiklkDISLDILPRDYPEPEFNFSTDHL 498  Kazachstania africana CBS 2517
CCK71402      444 DDVDG-------------LVNKLKSielqESTLKLRVEDYPEPLFEQFSEHs 482  Kazachstania naganishii CBS 8797
Q6CSF4        532 EEFDGnl---------------------tWSTLIVDVSEYKEPIVNEFDHHL 562  Kluyveromyces lactis
Q6FXF4        577 RELES-------------LSDELASlkleEKCLKIIRSDYPKPEIRSHDDHI 615  [Candida] glabrata
XP_003674489  463 EKLDK-------------LSEKLKStnieELILIVDTATYPRPSFLSHDEHL 501  Naumovozyma castellii CBS 4309
XP_003686968  479 TEVDMndipsiydeneieIANKLSEleiqTHTFNLDISNYSNPHIEIRAEHL 530  Tetrapisispora phaffii CBS 4417
XP_003679394  442 QEIDE-------------MTYKLQSvnskKNILEVTTNNYKDPSFEGHTDHL 480  Torulaspora delbrueckii
CDF89572      468 QEIDL-------------LATSLQG----SHTVIVAVDHYPQPFFAEYTDHL 502  Zygosaccharomyces bailii CLIB 213
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