Conserved Protein Domain Family
MAR_sialic_bdg
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pfam10564: MAR_sialic_bdg (491261 is an unknown moldel)
Sialic-acid binding micronemal adhesive repeat
This domain is a novel carbohydrate-binding domain found on micronemal proteins. Micronemal proteins (MICs) are released onto the parasite surface just before invasion of host cells and play important roles in host cell recognition, attachment and penetration. Toxoplasma gondii can infect and replicate within all nucleated cells. This domain interacts with sialylated oligosaccharides; the protein in Toxoplasma gondii is a monomer but several MAR domains are carried on the protein. Each MAR domain contains one central sialic acid-binding pocket.
Links
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Statistics
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PSSM-Id: 491261
Aligned: 7 rows
Threshold Bit Score: 119.865
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_018638476 543 LNAFCTTQFQKLCSETidGGRYCg-VSGAVARFGPGG--HDSDSQWRCYEESIMNTTTKG---VQCMDDCGNQMQCVGAV 616 
2_pfamImport   1 LDQRCQEIAAELCQGG--LRKMCvpSSRIVARNAVGIt-HQNTLEWRCFDTASLLESNQEnngVNCVDDCGHTIPCPGGV 77  
5_pfamImport   1 VDYYCAKRFEQQCAKGvlGKTYCt-DGLVVGRYVSQG--SKLEAGWHCFKGAEIAHSQRQ---VKCVDNCGNLMKCFGDV 74  
3_pfamImport   1 LDSYCHNRYKQLCDGG--NKNFC--DKTGVARYGTGIq-SQQTAEWRCYFAEVLKPSGRK---VQCVDDCGNYFPCLGVV 72  
4_pfamImport   1 IDDACQKLFNCHCKK---DKKFC---TTVVARKDRGRagSQNDAEWRCYSLEELDFQKTN---PSCIDECGNELPCQGAV 71  
6_pfamImport   1 LDTMCQDAMDEECRKGk-QTEDC--FGLWLARYELESs-PGGAGAWRCYPESRLDFTQLS----SCIDGCGNPISCRGQP 72  
1_pfamImport   1 MDNYCQTEMDQMCRVGk-WTTYC--YQLWLSRMVSTE--EDEEPKWRCYPFALLNFSDLS----TCIDGCSNRVPCHGAP 71  

XP_018638476 617 SVKTVATPPL-RALSAFISQRR 637 
2_pfamImport  78 HRQNSNHATRhEILSKLVEEGV 99  
5_pfamImport  75 NSSQTAKVAM-PGMDEWIDKRK 95  
3_pfamImport  73 DPNDTFHATAhNQILNFIKDGV 94  
4_pfamImport  72 PEESTHHITW-TKLPSKIDEAT 92  
6_pfamImport  73 AEVSPAFIDL-PALDKVAGDMS 93  
1_pfamImport  72 SPTSTLTTEF-SKLKTIAEN-- 90
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