3MP7,2WW9


Conserved Protein Domain Family
Plug_translocon
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pfam10559: Plug_translocon (This model is not part of the current CDD release)
Plug domain of Sec61p
The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilising Sec61p during translocon formation. The domain runs from residues 52-74.
Links
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Statistics
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PSSM-Id: 519446
Aligned: 106 rows
Threshold Bit Score: 30.0378
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3MP7_A        38 ILYYVlAEIPVYGIPE-RIQDYFQFLRVVLAGR 69  Pyrococcus furiosus
P28542        38 LLYFFlTNVKLFGLDIdASQQVFGRFSSILASG 70  Haloarcula marismortui ATCC 43049
3_pfamImport   1 VLYFFlTNVMLFGLDIgSDSAPLGRFSSILASG 33 
WP_020447083  38 VLYFFlTNVALWGMS--TNTDAFGQFRTVLAGS 68  Salinarchaeum sp. Harcht-Bsk1
WP_049953246  38 VLYFFlTNIDLLGAA--SGQDIYGQFRSVIAGS 68  Halostagnicola larsenii
WP_013878545  38 VLYFFlTNISLLGMQSgGANDLFGQFRAILAGS 70  Halopiger xanaduensis
WP_015301158  38 VLYFFlTNIAILGTSg-GGEDLFGEFRAILAGQ 69  Halovivax ruber
Q9HPB1        38 VLYFFlTNVPLWGIQt-AGNDFFGQFRSLLAGG 69  Halobacterium salinarum NRC-1
WP_011324153  38 VLYFFlTNVGIYGLG--QGEDIFGQFRTILAGE 68  Natronomonas pharaonis
WP_004043101  38 VLYFFlTNVTLFGVGt-GSQDIFGQFRSILGGG 69  Haloferax volcanii
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