3MP7


Conserved Protein Domain Family
Plug_translocon
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pfam10559: Plug_translocon (This model is not part of the current CDD release)
Plug domain of Sec61p
The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilizing Sec61p during translocon formation. The domain runs from residues 52-74.
Links
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Statistics
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PSSM-Id: 491257
Aligned: 104 rows
Threshold Bit Score: 30.4107
Created: 21-Aug-2024
Updated: 4-Dec-2024
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3MP7_A        38 ILYYVlAEIPVYGIP-ERIQDYFQFLRVVLAGR 69  Pyrococcus furiosus
WP_004043101  38 VLYFFlTNVTLFGVG-TGSQDIFGQFRSILGGG 69  Haloferax volcanii
P28542        38 LLYFFlTNVKLFGLDiDASQQVFGRFSSILASG 70  Haloarcula marismortui ATCC 43049
WP_020447083  38 VLYFFlTNVALWGMS--TNTDAFGQFRTVLAGS 68  Salinarchaeum sp. Harcht-Bsk1
WP_049953246  38 VLYFFlTNIDLLGAA--SGQDIYGQFRSVIAGS 68  Halostagnicola larsenii
WP_013878545  38 VLYFFlTNISLLGMQsGGANDLFGQFRAILAGS 70  Halopiger xanaduensis
WP_015301158  38 VLYFFlTNIAILGTS-GGGEDLFGEFRAILAGQ 69  Halovivax ruber
WP_004213691  38 mLYFFlTNITLLGIEaGQADDLFGEFRAILAGE 70  Natrialba magadii
Q9HPB1        38 VLYFFlTNVPLWGIQ-TAGNDFFGQFRSLLAGG 69  Halobacterium salinarum NRC-1
WP_011324153  38 VLYFFlTNVGIYGLG--QGEDIFGQFRTILAGE 68  Natronomonas pharaonis
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