Conserved Protein Domain Family
MTP18

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pfam10558: MTP18 (This model is not part of the current CDD release)
Mitochondrial 18 KDa protein (MTP18)
This family of proteins are mitochondrial 18KDa proteins that are often misannotated as carbonic anhydrases. It was shown that knockdown of MTP18 protein results in a cytochrome c release from mitochondria and consequently leads to apoptosis. Overexpression studies suggest that MTP18 is required for mitochondrial fission.
Statistics
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PSSM-Id: 519445
Aligned: 73 rows
Threshold Bit Score: 169.731
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_016292124   81 ERYAAYFMRLKTVIIASSRYVAYTSDIGEAFRPLTKPAVVKAAYGISWTYILGDVFYAGYKAAKQYEALASttfTSSSGP 160
XP_002668115   38 LRYLGYLGRLKTAIVAGARYLAYTSDVGEAFRPIVHPLIVRAGYGISWAYVLGDVGIQTYREKEKGSSTNT--------- 108
XP_006682338   10 LRILGYAGRLRNFVTAGSRYLAYTSDMGEAFRPVVPRSVVNAAYGVSFAYVGIDVAYEGYKSSLRGDSPME--------- 80 
XP_003319902   24 ARYLGLVARIRPLLIPASRYLAYTSDVGEAFRPVVNPKVVTSAYGISIGYVVGDVAYEGWKGHLQAQGDPD--------- 94 
KDE03011       31 ARYLAYLARIRPVLQPMTRYLAYTSDVGESVRPIVNPKMVTGAYGVSWAYLVGDVAYEGYKARLRANENCP--------- 101
XP_001730783   25 gRYSAYTMRLKTLVTSVSRYIAYTSDVGEAFRPLTRPIVVTSAYAISWAYIFTDVGWTCWQAAKLQDR------------ 92 
GAC75419       83 SRYAAYAMRLKTVIVASSRYVAYSSDIGEAFRPLTSPAFVRGAYAVSWTYILGDVVYAGYKAAQQYEALASttfSKSGPV 162
XP_012191542   85 gRYAAYAARLKTAVGSSLRMSAYTSEMGEALRPLTKPWVVRGAYAVSWTYIIVDVAYAGFKAAKQYESLASttfSATGPV 164
Q5KIX6         45 IRYAAYLRRARDVVRAGSRYTAYTSDVGEAFRPVVPPWLVTAAYGVSWAYLIGDVSFTTYKSSQLGPSPIEaanMSERTR 124 Cryptococcus n...
10_pfamImport   3 VRYAAYLRRIRDVARAGSRYTAYTSDIGEAFRPVVPPGVVTAAYAISWAYLIGDVSFTTYKAKEQGPTPWEaanFSEPTR 82 
XP_016292124  161 LQELEteaaryadkalssvkqnlpleklldhktlstlsptekvelrkrhtqrlaeaGQHAGVDPNQISEVTHVGL-T--- 236
XP_002668115  109 ----------------------------------------------------------------------------Vlrt 112
XP_006682338   81 ----------------------------------------------------------------------------Vtrt 84 
XP_003319902   95 -----------------------------------------------------------------------DNLV-Ialk 102
KDE03011      102 ----------------------------------------------------------------------EAVSTvVgln 111
XP_001730783   93 ----------------------------------------------------------------DSPTLASDIAW-I--- 104
GAC75419      163 QELESeaaqladkaltsarenlplekllda-ktlnalsptekvelrkrhverlaeqGDHAGVDPNQVSEATHVGV-V--- 237
XP_012191542  165 QELETeaaklanqtlssvrenlpleevlds-ktlsalspsekvelrkrhtqrlaehGRHAGVDPSKVSEVTHVGM-T--- 239
Q5KIX6        125 -------------------------------------------------------------LAM------------V--- 128 Cryptococcus n...
10_pfamImport  83 -------------------------------------------------------------LGL------------V--- 86 
XP_016292124  237 MARQAVFQSIASMALPAFTIHSIVRYSAP-LFAKA--KSQRIRAAGPTVAGLMFVPALPFLFDEPVEHVI 303
XP_002668115  113 ATKTAIFQSTASMILPMITIHQTVHVVSA-ILKKVgyKSKVI----PTISGLAVIPALPFMFDHPVEHFV 177
XP_006682338   85 VVERTIFQGLASLLLPAITIHSVVDLTTK-ALKNT--SINALKRWGPTAAGLAVLPVLPILLDRPVEYVM 151
XP_003319902  103 VARRAAFQGTASMLLPALTIHSAVRYSKKmIFSKM--ANPRIHSIGPTAVGLGIIPFLPTLFDEPVEHLV 170
KDE03011      112 VAKRAIFQCVASMLFPSLTIHAIVRYTAI-AVKKAnvKSIAVRRWLPSALGLGFIPALPFIFDEPVEHVV 180
XP_001730783  105 AARRGAFQSLASLVLPAVTIHSVVKHSAH-LFAKF--KSSRVRVAGPTAAGLLVVPLLPIVFDDPVETVV 171
GAC75419      238 MARRAVFQSIASMALPAFTIHSIVRYSAP-VFAKA--KSQRIRAAGPTVAGLMFVPALPFLFDEPVEHVI 304
XP_012191542  240 VARQAVFQSIASMALPAFTIHSIVKYTAP-VFAKA--KNHRIRAFGPTAAGLMFIPALPFLFDEPVEHVV 306
Q5KIX6        129 AVKRSVFQGVASMALPAFTIHTAVRYAGR-AFAKS--QNAILRRWGPTAVGIGIVPALPYMFDHPVEQAt 195 Cryptococcus neoformans
10_pfamImport  87 ATKRSVFQAVASMGLPALTIHTAVKQASK-LFANS--ANASLKRWGPTAVGISIVPALPYLFDHPVEVV- 152
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