Conserved Protein Domain Family
Membr_traf_MHD

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pfam10540: Membr_traf_MHD 
Munc13 (mammalian uncoordinated) homology domain
Munc13 proteins constitute a family of three highly homologous molecules (Munc13-1, Munc13-2 and Munc13-3) with homology to Caenorhabditis elegans unc-13p. Munc13 proteins contain a phorbol ester-binding C1 domain and two C2 domains, which are Ca2+/phospholipid binding domains. Sequence analyses have uncovered two regions called Munc13 homology domains 1 (MHD1) and 2 (MHD2) that are arranged between two flanking C2 domains. MHD1 and MHD2 domains are present in a wide variety of proteins from Arabidopsis thaliana, C. elegans, Drosophila melanogaster, mouse, rat and human, some of which may function in a Munc13-like manner to regulate membrane trafficking. The MHD1 and MHD2 domains are predicted to be alpha-helical.
Statistics
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PSSM-Id: 402254
View PSSM: pfam10540
Aligned: 51 rows
Threshold Bit Score: 80.005
Threshold Setting Gi: 344248559
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003645005 1075 DAISPLFDYLNSNLAIMATELNRSLLHKVMLQAWNTILNAADTLLLPNlssarsmkkavssksmt--------------l 1140 Eremothecium ...
Q6CVC9       1147 dSLVPLFDHLNENLTVLAQALPTALLHQIMLQVWNKILVAADALLLPPlqlasisssanseynfgsrg------------ 1214 Kluyveromyces...
EDK41640       13 EAMMPLYNYLNQNLEVLAQYLTQEMLMKVMVAAWNVVVSSADELLLPKlasaktfqlstigsklssts-------tgtsg 85   Meyerozyma gu...
Q5ABF8       1011 QSIQNLCDYLNMNLSILKGFLMNEIFMKTMVATWKNVVSAADELMLPKlskakintesggtsw----------------- 1073 Candida albicans
EER31613     1052 ASIENLCDYLNMNLSILKEFLMDENFMKVMVETWKHVINSADELMLPNlskakikaeggslsltssssssssshytntss 1131 Candida tropi...
EMG46783     1026 ASLENLCDYLNMNLSILKEFLMDENFMNVMIITWKTVIKAADELMLPKlskakintatsttsssasvslsl-sgtelnts 1104 Candida malto...
EGW34736      993 AAIEHLCDYLNMNLCVLKEFLKDEIFMKVMVATWNVVVTSADELVLPKlskasvtlesggns------------------ 1054 Spathaspora p...
XP_001526545 1045 ASIENLCDYLNLNLSVLKQYLCDDIFMEVMIATWKVVIKYADQLMLPKlskakadvvdsnsw------------------ 1106 Lodderomyces ...
CCE40964      998 ESIENLCDYLNLNLSTLKTYLRDDLFMEVMLATWNIVIKCADELLLPKlskakidvdsstws------------------ 1059 Candida parap...
XP_002618004  885 EAMKPLYNYLNMNLSVLAQYLSKEILLRVMIEAWNVVVASADELLLPKltsarvlrnstlgykrtsasg-----gniktg 959  Clavispora lu...
XP_003645005 1141 wenamniakgengadSyysyyysgsssssgtltsnggtgsgaiagliggpaaggqsdgqgsggllasgqaaeannynnNI 1220 Eremothecium ...
Q6CVC9       1215 ------------------------------------------------------------nrmsysgstrgsssvwdtaV 1234 Kluyveromyces...
EDK41640       86 wqsavstavasvsnsI--------------------------------------------------------------GI 103  Meyerozyma gu...
Q5ABF8       1074 -qsvssklatvslssI--------------------------------------------------------------GI 1090 Candida albicans
EER31613     1132 wqsmtskfsnvslasI--------------------------------------------------------------GI 1149 Candida tropi...
EMG46783     1105 wqsmtskfsnvslssI--------------------------------------------------------------GI 1122 Candida malto...
EGW34736     1055 -----------------------------------------------------------------wqavsskfanvslgI 1069 Spathaspora p...
XP_001526545 1107 -qsmstklalvslttM--------------------------------------------------------------NM 1123 Lodderomyces ...
CCE40964     1060 --amsskfanvsistK--------------------------------------------------------------AM 1075 Candida parap...
XP_002618004  960 wqsavssavanvtnsM--------------------------------------------------------------NI 977  Clavispora lu...
XP_003645005 1221 VGFGMTL-----------------------TQREVDIVFEWLRALCvDFFHNSGEGPPLQALKNQHYQNLLLVPVFYDKS 1277 Eremothecium ...
Q6CVC9       1235 SGFQKVLqkpgftgwsspfsnnsnynntvgTSLEVEIVFMWIDILCrDFFHNNGEGPPLDKLKNDQYQQLMLIASLFDNE 1314 Kluyveromyces...
EDK41640      104 SGFGRSL-----------------------TNNELETVFAWLTFLCfDFFHNNGNGPPIADLKNEHYQSLLLVPVYYDRD 160  Meyerozyma gu...
Q5ABF8       1091 LGIDGPL-----------------------SINEIETVLGWLNFLC-TFFHHEGNGPPMEDLKTDQYQSLLLVPALYDQT 1146 Candida albicans
EER31613     1150 SGMDGPL-----------------------SIVEIETILQWLNFLC-SFFHNEGNGPPMEDLKTDKYQSLLLVPALYDQS 1205 Candida tropi...
EMG46783     1123 LGMDGPLl----------------------SINEIETILGWLGLLC-QFFHNDGNGPSMEDLKTDQYQSLLLVPALYDQT 1179 Candida malto...
EGW34736     1070 LGIDSPL-----------------------SDIELETVLFWLSLLV-SFFHNEGNGPPMEDLKTEQYQSLLLIPALYDQG 1125 Spathaspora p...
XP_001526545 1124 FGINSPL-----------------------SAIEVETVLRWLDLLM-EFFHNEGNGPPLEELKTDEYQALLLIPAFHDQN 1179 Lodderomyces ...
CCE40964     1076 FGIDSPL-----------------------SIVEIETVLRWLYLLT-EFFHNEGNGPPMEDLKTEKYQSLLLIPAYYDQS 1131 Candida parap...
XP_002618004  978 LGFGKTL-----------------------TNNEIETVISWLDFLCiDFFHNEGNGPPVEDLKTEQYQSLLLIPVYYDRD 1034 Clavispora lu...
XP_003645005 1278 VEEL 1281 Eremothecium cymbalariae DBVPG#7215
Q6CVC9       1315 TCEL 1318 Kluyveromyces lactis
EDK41640      161 IEFL 164  Meyerozyma guilliermondii ATCC 6260
Q5ABF8       1147 DEYL 1150 Candida albicans
EER31613     1206 DDYL 1209 Candida tropicalis MYA-3404
EMG46783     1180 DEYL 1183 Candida maltosa Xu316
EGW34736     1126 DDYL 1129 Spathaspora passalidarum NRRL Y-27907
XP_001526545 1180 DEVL 1183 Lodderomyces elongisporus NRRL YB-4239
CCE40964     1132 EDEL 1135 Candida parapsilosis
XP_002618004 1035 TSFL 1038 Clavispora lusitaniae ATCC 42720
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