Conserved Protein Domain Family
CRIC_ras_sig

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pfam10534: CRIC_ras_sig 
Connector enhancer of kinase suppressor of ras
The CRIC - Connector enhancer of kinase suppressor of ras - domain functions as a scaffold in several signal cascades and acts on proliferation, differentiation and apoptosis.
Statistics
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PSSM-Id: 402249
View PSSM: pfam10534
Aligned: 33 rows
Threshold Bit Score: 93.4493
Threshold Setting Gi: 780145873
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EKC38456       88 LQSLALQLGCKARSLFNEVQPRNLENDpnmanhshssrSRPHQLSVEILSSVADLIITLKCVIQWLDRAPFDRIYDMILL 167  Pacific oyster
XP_009860005   83 LQTRALCLNCRCRSLRSTIVNRRQEVEdyey---dggvSLHRGPTNQLLRLAANVLDEGKQLVLWLDRVPFTYKPEFRSI 159  vase tunicate
EFX63068       85 LQYLAMQLGCKARSLYNELRIIYQSFDn----------GKTEQVTTATLAAVADIIDQVKDLLSWLDRTPFDGHEPYLEV 154  common water ...
XP_015793041   83 LQMLSLRLGCKARSLFNILKRETDEEE-----------KYRDRVTTKTLSGVCDILTSVKLFVSWIDRYPFGGQEEYISI 151  two-spotted s...
XP_002612583   81 LQSLTVALGLNVENLDMAMTVRNQQSIlvgl----agpRDNYKLPPDILRAICDVLSAAKAVVSWLDRTPFVQMMNYIAI 156  Florida lancelet
XP_011681328   66 LQSVTLNLNTRTNCLTKYLQRCSRNGGhhpg---rngtNVPQSVPASVLVLIAEIVTAAKTVISWLDRPPFVTGDHFFKM 142  purple sea ur...
XP_016159166   79 LRTLTERLQELAQGVQGLVQGELPAG------------DAPQPPSLTLLARVIDLVGAAKELFSWLNRYLFSTLNDFSAS 146  collared flyc...
KAE8623849     79 LRSLTEKLYGVSQSLWSHILSMRKVASh----------SLSAAPTPKQLVCIIDIVAAARGLFSWLNRYLFARLNDYSAS 148  tropical claw...
XP_005994001   79 LRTVVEKLKAVCHTLQALILSRRKVNTyd--------gASVQKTSMDLLSSIIEIIAAAKAVFTWLNRYLLMCLSDYSAS 150  coelacanth
XP_020658894   79 LRTLTEKLQGVVQTIQAFILSRRKVSTyn--------gDAVDRPPSDLLACIVELIGAAKGLFLWLNRYLFSHLHDYSAS 150  central beard...
EKC38456      168 -RNTLVKLGIDLISACQKD 185  Pacific oyster
XP_009860005  160 -RDNLVRLCYELSTTMQHS 177  vase tunicate
EFX63068      155 -KGNLLKICLELATNAQRD 172  common water flea
XP_015793041  152 -RKEILKLSIELASTAQRD 169  two-spotted spider mite
XP_002612583  157 -RNRIVRICLGFTSSIHKD 174  Florida lancelet
XP_011681328  143 fREDILKSALDLTQVGQQT 161  purple sea urchin
XP_016159166  147 -RD-IILLCAQLAEMLQAD 163  collared flycatcher
KAE8623849    149 -RD-VIVLCLELAESVHKD 165  tropical clawed frog
XP_005994001  151 -KE-IFILCSDLATCVNKD 167  coelacanth
XP_020658894  151 -RD-IIWLCGDLAELVQKD 167  central bearded dragon
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