4ASL


Conserved Protein Domain Family
GLEYA

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pfam10528: GLEYA 
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GLEYA domain
The GLEYA domain is related to lectin-like binding domains found in the S. cerevisiae Flo proteins and the C. glabrata Epa proteins. It is a carbohydrate-binding domain that is found in fungal adhesins (also referred to as agglutinins or flocculins). Adhesins with a GLEYA domain possess a typical N-terminal signal peptide and a domain of conserved sequence repeats, but lack glycosylphosphatidylinositol (GPI) anchor attachment signals. They contain a conserved motif G(M/L)(E/A/N/Q)YA, hence the name GLEYA. Based on sequence homology, it is suggested that the GLEYA domain would predominantly contain beta sheets. The GLEYA domain is also found in S. pombe putative cell agglutination protein fta5, thought to be a kinetochore portein (Sim4 complex subunit), however no direct evidence for kinetochore association has been found. Furthermore, a global protein localization study in S. pombe identified it as a secreted protein localized to the Golgi complex.
Statistics
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PSSM-Id: 402245
View PSSM: pfam10528
Aligned: 185 rows
Threshold Bit Score: 61.7806
Threshold Setting Gi: 729181202
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4ASL_A        129 FTMLLYGYFRPKVTGFHTFTI---SADDLLFVNFGAGnAFDCCRRDssadhfgNY--QAYAIWg-SkTAKDELT--VHLD 200  [Candida] gla...
KLU90832      214 AVLQHRGYIMADQTGIYKATA---GADEMVLGWFGAS-AVSGWTTA-------NA--QLKAGYg---FGTSQYT--FTAT 275  Magnaporthiop...
KLU83741      155 SVLQACGCIVADRVTTYHIYFn--SAGELALGWFGDE-ANGNWNSD-------NA--RLVT------GRYAYRA--IQAK 214  Magnaporthiop...
KDB13983     1576 AAVQHVGYFHPAITGLYNFSFn-gYVNDAQYLWLGKN-AVSGWTNN-------NA--NLVATL----MSTQSFT--FSAT 1638 Ustilaginoide...
KDB12132      209 IVIQFVGYFHPALTGNYVFQLg-pNADEASYLWVGNY-AVSGWNTG-------NA--NAKLAD----SGASSLV--YSAT 271  Ustilaginoide...
KDB15989     1999 MVVQHVAYFNPSMTGTYVFSFq-gGDDDGAYLWLGPN-AVAGFKRA-------NA--NLVSGTqaS-LTGPTVS--YSAI 2064 Ustilaginoide...
EGR45568      765 TIVQQIGWFVPAIAGTYTFTApaaTLDQSVYVWLGAN-AVAGYTNT-------NAdlVADANW--LsGSNLDLEvvSAAQ 834  Trichoderma r...
XP_007590514 1724 WYIQQAGYFHPSQSGTYTFAFs--TADEGGYVWVGDK-ALSTFTNS-------NA--DLIR-Yt-QqSTTPTFS--FTAV 1787 Colletotrichu...
XP_007590863 1789 IIVQHIGYFHPATSGTYTFSFs--GVDDSVYLWLGKSvAKTGYSNA-------NY--DKNVNYy-DtNMSGTFT--FTAT 1854 Colletotrichu...
GAO18548      933 IVTQNVGYFHPAITGSYNFSFt-gWINEAQYLWLGNN-AMSGWNSG-------NA--NLIGTW--G-QVNQSFT--LSAT 996  Ustilaginoide...
4ASL_A        201 AGVYYPIRLFYNNREyD-GALSFTFKT 226  [Candida] glabrata
KLU90832      276 AGDVIPFRVLFVNAQ-GcYYLGFTLTR 301  Magnaporthiopsis poae ATCC 64411
KLU83741      215 AGDVIPFRILYINAQ-GcYSFGFTIYK 240  Magnaporthiopsis poae ATCC 64411
KDB13983     1639 AGTYIPFRLLYANAQ-AvGALAFTLTD 1664 Ustilaginoidea virens
KDB12132      272 AGTFIPFRLLFVNAQ-GsSGLGFSLKD 297  Ustilaginoidea virens
KDB15989     2065 AGTFIPMRILCVNSP-GpTACGFTLID 2090 Ustilaginoidea virens
EGR45568      835 VGTYIPIRILWVNAQ-DcGQFDLTITD 860  Trichoderma reesei QM6a
XP_007590514 1788 AGAYYPIRFLYVNAQ-GcYGNGLTITN 1813 Colletotrichum fioriniae PJ7
XP_007590863 1855 AGQYYPIRILFVNAQ-QcGLFNFSLTN 1880 Colletotrichum fioriniae PJ7
GAO18548      997 AGDYIPFRLLFVNAQ-TtSALSFTLTD 1022 Ustilaginoidea virens
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