Conserved Protein Domain Family
Tti2

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pfam10521: Tti2 
Tti2 family
This family includes budding yeast Tel2-interacting protein 2 (Tti2) and similar proteins from animals and fungi. Tti2 is a component of the tel2-tti1-tti2 (TTT) complex, which is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Its homologue from humans, together with the TTT complex and HSP90, may participate in the proper folding of newly synthesised phosphatidylinositol 3-kinase-related protein kinase (PIKK) proteins.
Statistics
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PSSM-Id: 491231
Aligned: 60 rows
Threshold Bit Score: 153.21
Created: 15-Feb-2025
Updated: 25-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_001538902 153 VITSIAAFTCRL--DPWTTEQAFDDASTI--LQNyesflrsnRREEELTAVLENILRKKVKPLFSKtk------------ 216
Q6CWH6        48 GLVSLSYFLLNE---HWTRYEQRDRVTHL--IDNyl----------dRDHDLVHSFISALKPMLIKstginndnltpsgr 112 Kluyveromyces l...
XP_004178145  41 LLKNLSLLTLENd---------SRKETSLylIQKll-----dKSDERARTILLEDFISFVKNNLLFikqr---------h 97 
XP_001643571  46 LLNIFSTFSLGMdkKSSI---------CFntLNQvl-----gCADDANSRWMLHGLIDHLQPLLLKcs------------ 99 
XP_022463352  48 LIQQLSCFALDQd--------aKKAQCVIkfVNT--------LWDATDGDPLYVDLIPLLKPHLLLnlgdgs------sa 105
XP_007376662  93 LIYTLSLHSNPN--VPWCNNINSQIVTSIi------------TEINMPNEIIEDFIENEYKRNIQQvk------------ 146
XP_001387248 127 IMRLLACYTNPN--LPWTSEITEKIVGSV-----------------DVEDMMEELIETELKPNLLV-------------- 173
Q6BN22       148 LLAPLSYHMHPK--LPWTSELNSKTIENFiaDNN--------KVRDMIHSVIPLYIDKKLKPELLNlsstkgqy-irnsl 216 Debaryomyces ha...
XP_001483237  44 TIEAISQHANPY--LSWCSSEGAALVMEI-------------VDSSCSGKNIDDFVEEKVVPRMQTlps----------- 97 
CCE79145     140 LLSSISYHIHPS--LPWTCSKNANIIHKI--LENf-------SKSASFESAMDTLFNGELKASLLVlsskhvpsqrdksl 208
XP_001538902 217 -tpAVTAAGRKNVHpipq--------------prfDPSIFDPES--KPWK-FRYVYIITVLSWVIERYSPSdkfSLESQF 278
Q6CWH6       113 rkiESSRPGLQPRL---------------------GFEQTFGESrwKEWRtNGGLRSIGLFYIILRHLGKQ---EISANL 168 Kluyveromyces l...
XP_004178145  98 httREENIGLNPKL---------------------GISLEDDQLr-DTWRaNGGIYVIPMFFTAIHFMERQ---NISSNI 152
XP_001643571 100 --nSGKTEGLRPNL---------------------GFSIKNDDLr-TKWLdCGGLQSIPLFYTILRFMKRN---EISSNL 152
XP_022463352 106 krrNRVAPGLNPVL---------------------GVSSQEDEIr-SRWKsQGGWKHVGLFYIVLLHLQHR---DVSVEL 160
XP_007376662 147 --sERSSSGlrprl----------------gfnsvASEISSSE---QIEKlKAYPISLSQAWFLIEISTDKhr-wcSQVF 204
XP_001387248 174 ---LPKVAGKKALQgglnpr---------lgyggaKREILEEDAr-RNWKsGTKVKALSVAYFIIKLAPSTfw--sAGNW 238
Q6BN22       217 snpKTTPAGYAIGNsgstrllqgg-lrpklgyggtRTEVIAEDQr-QAWKsSTKVKSISMIWFVIYTITSNeh--lNQFW 292 Debaryomyces ha...
XP_001483237  98 -sqKTTSAGYAAKRtlgglkp-------rlgftqsEQELSIPETt------------YSMIYFCISCQHKGtw--ySSRW 155
CCE79145     209 hnpRLTSAGYASTLlkkkdingksalrpslgfsgvNEEINESDQr-RLWKmSSHVKVLSMIYLMIYFSGDFsr--iEDNW 285
XP_001538902 279 PLLVPAILSLIDDEN---LSFKAKGCELLLKFLSPLEQSns------dVLQRTNLDSVFQEALYPCLLSIPTITPEAESI 349
Q6CWH6       169 PWISPGILNIIDDTTlgpENVRVYGIMLLCTLLESVLNKrdt---ynfNFKDTGLQKVYEPILTNLLYNLPPSSTPEETL 245 Kluyveromyces l...
XP_004178145 153 NWIVPGILNILDDTSd-iLNIKLKGVSLLNELLCITSTNvkd---sflSFDQLGLFELFEPILSNMFYYLPPSYDSKIVL 228
XP_001643571 153 WWITPGILNLLDDTTd-lERIKLGGVKLLQVLLEHTFAGsvvederwmSFPETGLFKLYEPILINMTYYLPPSYSSKETL 231
XP_022463352 161 RWITPGILNLLDDPHd--IPLRVQGVQLVHAFVEVFRDPeh-----wvPFSSTGLFLLFEPVLKNMCYLVPTLYSTMDTT 233
XP_007376662 205 NLTISFILNLLDLSD---IEIKTHACQLLQFLLSKSSH----------FKFNSGLIKEVSKSLSKCLVYIPPSVSVDRSL 271
XP_001387248 239 RVISSFILNVGDDHD---PLFKYQSVKLLALMTERLEQLdh-----idVIRSSGLIDVLSESVRKCLVYYPSTTTVNTSL 310
Q6BN22       293 PLITSFILNLIDDHD---PLMKAQSCELLNYFMLMIDHSkdy---kqhILLKTGLVDLLIESCKTCLTYLPNLTPSDQSF 366 Debaryomyces ha...
XP_001483237 156 SLVTSFILKVLDDPS---AVIKIQGCRLLDHFLLFPQATs--------LLDRTGLRDLFSDSTKVCLSYLPGMTPLDQSL 224
CCE79145     286 AFITSFILNVLDDHD---PLIKAQGCYLLHYLILHWRGKggs----snLLLKTGLCDLFKSSIGVCLTYLPNLTPLDQSI 358
XP_001538902 350 HLLQYAYPALFAVIRTRFSspkvPSAPtllrpyqtkmkhdpdsqkRLESLTRLLRHGILH------SYHHtsnprpient 423
Q6CWH6       246 RTWKVTYPALQLILRVEAS----DNDQd-----------------FRDRLGHMFSENILQltipriGLDY---------- 294 Kluyveromyces l...
XP_004178145 229 KIWNQLFPTIILLYKTKPD----HD--------------------CHQVLCKFISEIILQnilpriSLDH---------- 274
XP_001643571 232 MVFEMVFPTLELLYKREFN----DNRAm-----------------YQKNLQKILSVVILQnvmprvTYQY---------- 280
XP_022463352 234 RVWRSVFPALIALYRVEFS----DTLE------------------YFRHLQSMCSEIVLRgliprlGVKY---------- 281
XP_007376662 272 PILSQAYPCLIEVYSTYG---------------------------TNLDYVELIST-IIS------NVNHll-------- 309
XP_001387248 311 LLLDASYPLLFKLFDISGT--------------------------DWTEIMDVISSNIMG------AISHlig------- 351
Q6BN22       367 YLLSIAYPTVVKLCVLNCK----KEA-------------------NFLSLVELINGNILS------SATHihn------- 410 Debaryomyces ha...
XP_001483237 225 PLLDIAYVVMFKLEGKNVH--------------------------KMLDMLSGILRAILS------KINEp--------- 263
CCE79145     359 FILKLAYPTYYSLLQLEQD----KES-------------------KLLSYLDTINSHILT------SISHvfn------- 402
XP_001538902 424 siSSYPyPRLSALLLSQLPPALSE-LGIHTTKHLQDLVPTISA-ALSNPFGTA 474
Q6CWH6       295 -------PGLSLWILGYCQDVVLM-LGKETTLYLQRVIYVLGEfYFRNAFMTL 339 Kluyveromyces lactis
XP_004178145 275 -------EELTMFVLDQLINLIKF-IQNDTLVILQRLIFVIGEyLVKNPFITT 319
XP_001643571 281 -------EDLTLYILNLTVELLNE-LQGASVIHLSRLIFNLGEyVIRNPFFTA 325
XP_022463352 282 -------PTLTVQLLTTLSELLSK-MGPLSVVLLQRTVYTLGEcIVSDPFFTV 326
XP_007376662 310 tsEVEItEPVLVLLLDQVLVMSEK-LDTDITICLSKLLYTLNQ-VIVNINICE 360
XP_001387248 352 tvEASSgFPVVCFLLDQLSEIVATsIKTKILISISRLFFMLNS-IITN-ITVL 402
Q6BN22       411 snGPNSnYPLLSLLFNQLDIIIKYyLKTNVLICLSRLNFTINQ-VMSNPDIFE 462 Debaryomyces hansenii
XP_001483237 264 -eIQNSqYKLPILLLQKLKKCLGT-LEHRFVASLSRVNYTLNQ-VIVNPGATE 313
CCE79145     403 tkGYISsYSLVTFLFEQLQIVIGDyMRDFVLTCYDRIHKLIYQ-LLINLDIQE 454
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