Conserved Protein Domain Family
Tti2

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pfam10521: Tti2 
Tti2 family
Budding yeast Tti2 is a subunit of the ASTRA complex, which is involved in chromatin remodelling. Tti2 homolog from humans, TELO2-interacting protein 2, is part of the TTT complex that is involved in the cellular resistance to DNA damage stresses.
Statistics
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PSSM-Id: 402242
View PSSM: pfam10521
Aligned: 65 rows
Threshold Bit Score: 150.126
Threshold Setting Gi: 74686035
Created: 21-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDN09340     153 VITSIAAFTCRL--DPWTTEQAFDDASTI--LQNYESflrsnRREEELtaVLENILRKKVKPLFSK-------------T 215 Histoplasma cap...
Q75DU8        49 AAQYLAYYSMSErvKQSTIDQCIQIFKEI------------------MtdELLDHLIQQLQPMLLRtnnsr----ttaaG 106 Eremothecium go...
Q6CWH6        48 GLVSLSYFLLNE---HWTRYEQRDRVTHL--IDNYLD----------RdhDLVHSFISALKPMLIKstginndnltpsgR 112 Kluyveromyces l...
CCK69106      48 LIQQLSCFALDQd--------aKKAQCVIkfVNT--------LWDATDgdPLYVDLIPLLKPHLLLnlgd------gssA 105 Kazachstania na...
XP_002495325  45 VIQCLSYFTMDKepRGSK---------CLetIKIVVDkl--tNDTNWSydELLTWLIDRLRPLLLRtke--------ssR 105 Zygosaccharomyc...
XP_003680843  45 FILNLSYLTLNKgtIGRI---------SIetVHRLI------TKSRVNeeEIVKWLIENLQPLLLRt-----------eD 98  Torulaspora del...
EJT41328      68 LIESLSYLSLSPgtEIQINND------VIktIDKRF------QSGRNHygDIVRGLISSLQPLLLKgk---------snS 126 Saccharomyces k...
XP_001643571  46 LLNIFSTFSLGMdkKSSI---------CFntLNQVLG-----CADDANsrWMLHGLIDHLQPLLLK-------------- 97  Vanderwaltozyma...
XP_004178145  41 LLKNLSLLTLENd---------SRKETSLylIQKLLD-----KSDERArtILLEDFISFVKNNLLFik---------qrH 97  Tetrapisispora ...
CCF58588      51 AIKALSYFTMDPd--------mKVRKIAIstMEELCA----------KdsNLLPQLIDDVRNSLQKl------------G 100 Kazachstania af...
EDN09340     216 KTpaVTAAGRKNVHpipqprfDPSIFDPEs--KPWK-FRYVYIITVLSWVIERYSPSdkfSlesQFPLLVPAILSLIDDE 292 Histoplasma cap...
Q75DU8       107 RFkkETATKLKPQL-------GFGIENENa-vSAWKrSGGLRSIPLFYVVLSVLKHE---SissNLWWISPGILNLLDES 175 Eremothecium go...
Q6CWH6       113 RKieSSRPGLQPRL-------GFEQTFGEsrwKEWRtNGGLRSIGLFYIILRHLGKQ---EisaNLPWISPGILNIIDDT 182 Kluyveromyces l...
CCK69106     106 KRrnRVAPGLNPVL-------GVSSQEDEi-rSRWKsQGGWKHVGLFYIVLLHLQHR---DvsvELRWITPGILNLLDDP 174 Kazachstania na...
XP_002495325 106 QSnkNENNALKPKV-------GQSYKEDEq-rQAWRnEGGLKSIPFFYVVLFNLKNR---HvssNLWWITPGILNILDDT 174 Zygosaccharomyc...
XP_003680843  99 RRrdTVKSGLRPSV-------GMSLKDDEa-rRIWKeRGGIRSIPLFYVVLLHLQHR---NvssNLWWITPGILNLLDDT 167 Torulaspora del...
EJT41328     127 ELkgQQNLVLKPAL-------GMSLKEDNl-rEVWIgQGGLKSIPLFYVVLLHLKRK---DvstNLSWIVPGILNILDDT 195 Saccharomyces k...
XP_001643571  98 CSnsGKTEGLRPNL-------GFSIKNDDl-rTKWLdCGGLQSIPLFYTILRFMKRN---EissNLWWITPGILNLLDDT 166 Vanderwaltozyma...
XP_004178145  98 HTtrEENIGLNPKL-------GISLEDDQl-rDTWRaNGGIYVIPMFFTAIHFMERQ---NissNINWIVPGILNILDDT 166 Tetrapisispora ...
CCF58588     101 HRgkDEQNGLKPQL-------GLALKGDKi-mSDWKsQGGLKDIPIFNTILLNLPRN---QiseNLWWIRPGILSLLDDT 169 Kazachstania af...
EDN09340     293 N---LSFKAKGCELLLKFLSPLEQSNSd------VLQRTNLDSVFQEALYPCLLSIPTITPEAESIHLLQYAYPALFAVI 363 Histoplasma cap...
Q75DU8       176 Dd-iEKVKLPAVKLLRRFLECTIDVSDav---hfSFAATGLFAVYQPILVGLCHQIPPIIEARQSQIIWNTAYPTILALY 251 Eremothecium go...
Q6CWH6       183 TlgpENVRVYGIMLLCTLLESVLNKRDty---nfNFKDTGLQKVYEPILTNLLYNLPPSSTPEETLRTWKVTYPALQLIL 259 Kluyveromyces l...
CCK69106     175 Hd--IPLRVQGVQLVHAFVEVFRDPEhw-----vPFSSTGLFLLFEPVLKNMCYLVPTLYSTMDTTRVWRSVFPALIALY 247 Kazachstania na...
XP_002495325 175 Td-iVGVKLKGVILLRVFLENCFEDQkn----wvSFSDLGLYELYSPILWNLCYYLPPSYDSNTSLSILQTVFPTLNSLY 249 Zygosaccharomyc...
XP_003680843 168 Td-lAGIKLRGVLLLRTFLSNAFKDQth----wiSFKETGLFKLYEPILLNMCYYLPPSYSSDESLKVWREVFPTLNSLY 242 Torulaspora del...
EJT41328     196 Td-lRRIKLRGVLLLQTLLDHTFVCEidds-kwiQFSSIGLFPLLEKILVNMCYFLPPSYNANDTLAIWRVVFPTIHSLY 273 Saccharomyces k...
XP_001643571 167 Td-lERIKLGGVKLLQVLLEHTFAGSVvederwmSFPETGLFKLYEPILINMTYYLPPSYSSKETLMVFEMVFPTLELLY 245 Vanderwaltozyma...
XP_004178145 167 Sd-iLNIKLKGVSLLNELLCITSTNVkds---flSFDQLGLFELFEPILSNMFYYLPPSYDSKIVLKIWNQLFPTIILLY 242 Tetrapisispora ...
CCF58588     170 Td-lRGIKLNGVKLLGTLVDRCFIDVsdk---wiSFKETGLFDLTEPMVRNLCYYLPPTYSMEDSISVFEAVIPTLRCLY 245 Kazachstania af...
EDN09340     364 RTRFSspkvPSAPTllrpyqtkmkhdpdsqkRLESLTRLLRHGILH------SYHHtsnprpientsissypyPRLSALL 437 Histoplasma cap...
Q75DU8       252 RVQYA----NEGPE-----------------YKAELGQIFSELVLQlalpkvSMDH-----------------LELTNTL 293 Eremothecium go...
Q6CWH6       260 RVEAS----DNDQD-----------------FRDRLGHMFSENILQltipriGLDY-----------------PGLSLWI 301 Kluyveromyces l...
CCK69106     248 RVEFS----DTLE------------------YFRHLQSMCSEIVLRgliprlGVKY-----------------PTLTVQL 288 Kazachstania na...
XP_002495325 250 RLQFI----SSDLK-----------------YKYHLGKFLSEILLQnliprvNFIS-----------------EPLTAYA 291 Zygosaccharomyc...
XP_003680843 243 TTQFK----NREII-----------------CRKYQGKFLSEFLLQqaipriNLTS-----------------ETLAIYT 284 Torulaspora del...
EJT41328     274 RVEFV----NDNTK-----------------YQYHLEKFMSEILLQniipraSLTY-----------------DNLTTYA 315 Saccharomyces k...
XP_001643571 246 KREFN----DNRAM-----------------YQKNLQKILSVVILQnvmprvTYQY-----------------EDLTLYI 287 Vanderwaltozyma...
XP_004178145 243 KTKPD----HD--------------------CHQVLCKFISEIILQnilpriSLDH-----------------EELTMFV 281 Tetrapisispora ...
CCF58588     246 KAQYD----IKDC------------------KDMIGAKILSQILLQhvipriGIRY-----------------EKLSELV 286 Kazachstania af...
EDN09340     438 L-SQLPPALSELGIHTTKHLQDLVPTISA-ALSNPfgtA 474 Histoplasma capsulatum NAm1
Q75DU8       294 L-DYTIQTLELLGAFSVRYLQRSIYVLGEyIVRNPfltL 331 Eremothecium gossypii
Q6CWH6       302 L-GYCQDVVLMLGKETTLYLQRVIYVLGEfYFRNAfmtL 339 Kluyveromyces lactis
CCK69106     289 L-TTLSELLSKMGPLSVVLLQRTVYTLGEcIVSDPfftV 326 Kazachstania naganishii CBS 8797
XP_002495325 292 L-DVCCRCVRILGVSSAVHLQRMIYVLGEyLVRNPfftA 329 Zygosaccharomyces rouxii
XP_003680843 285 L-DSLISLMKILDTSTLYHMSRIIYTLGEyLLRNPfftA 322 Torulaspora delbrueckii
EJT41328     316 L-ETATNILKLQKGGSVVHLQRLVYVLGEyIVRNPfftI 353 Saccharomyces kudriavzevii IFO 1802
XP_001643571 288 L-NLTVELLNELQGASVIHLSRLIFNLGEyVIRNPfftA 325 Vanderwaltozyma polyspora DSM 70294
XP_004178145 282 L-DQLINLIKFIQNDTLVILQRLIFVIGEyLVKNPfitT 319 Tetrapisispora blattae CBS 6284
CCF58588     287 IsDIMCPMIRSLGETCVPYLQRIIFTVGEyLVRDPfitT 325 Kazachstania africana CBS 2517
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