6IYC


Conserved Protein Domain Family
APP_amyloid

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pfam10515: APP_amyloid (This model is not part of the current CDD release)
Beta-amyloid precursor protein C-terminus
This is the amyloid, C-terminal, protein of the beta-Amyloid precursor protein (APP) which is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the pathogenesis of Alzheimer's disease but whose normal biological function is unknown. The C-terminal 100 residues are released and aggregate into amyloid deposits which are strongly implicated in the pathology of Alzheimer's disease plaque-formation. The domain is associated with family A4_EXTRA, pfam02177, further towards the N-terminus.
Statistics
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PSSM-Id: 519427
Aligned: 12 rows
Threshold Bit Score: 62.7757
Created: 15-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6IYC_E        30 IVITLVMLKKK-QYTSIHHGVVEVDA------AVT---P---EERHLSKMQQNGYENPTYKFFE 80  human
EEC20286     232 LLVGAVLLRRQaQRSPQAQGFVQVDQga---lPAS---P---EERHLASMQVNGYENPTYKYFE 286
EFN78149       4 AVVGVAVFKRRsARSPHSQGFIEVDQ------AAT---P---EERHVANMQINGYENPTYKYFE 55 
EDX16764     427 VFVGVAVAKWRtSRSPHAQGFIEVDQ------NVTthhPivrEEKIVPNMQINGYENPTYKYFE 484
XP_040022221 665 MVISLLLVRRK-PYGTISHGIVEVDP------MLT---P---EERQLNKMQNHGYENPTYKFFE 715
4_pfamImport   1 AVVSMILRNRR-----STPNVVRINE------NVD---DltqDEKQLLQMQHNGYENPTYKYLE 50 
EDO45291     525 IIVAMAMRRSRg---SSATKTVLVDPd----------aDgnsEKQRLTDLQENGYENPTYKFYD 575
XP_009020543 847 IIAGVMIMRRRaAVSKQQHKILPTEPvig-dlVTS---P---EESHVMNMQVNGYENPTYKYFE 903
XP_016882226 544 IVLSMLLLRRKkPYGAISHGVVEVDP------MLT---L---EEQQLRELQRHGYENPTYRFLE 595 human
XP_042199840 616 IVISLVMLRKR-QYGTISHGIVEVDP------MLT---P---EERHLNKMQNHGYENPTYKYLE 666 elephant shark
XP_009019810 537 IVVGVLIMRRRgNGFYSNNGRMEGERaendalNVS---P---EEQHVASMQVNGYENPTYKYFE 594
Q10651       637 IAFAITNARRRr----AMRGFIEVD-------VYT---P---EERHVAGMQVNGYENPTYSFFD 683 Caenorhabditis elegans
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